Research to Support Nerve Regeneration
Alexandra Katsoulakis '26
Amherst, Massachusetts
What drew you to this field of study?
I decided to major in biomedical engineering in high school after witnessing the development of COVID-19 vaccines, which initially sparked my interest in the field. It wasn’t until I joined Assistant Professor Dmitry Kireev’s lab, however, that I became particularly interested in bioelectronics. Working hands-on with bioelectronic projects has allowed me to see the powerful potential of combining engineering and biology to develop innovative medical technologies.
How do you conduct your research?
In my research, I’m working toward creating flexible "nerve cuff electrodes" to help spinal nerves heal after injury. While I haven’t built the final device yet, my work focuses on developing the materials and techniques needed. This includes testing graphene, a thin, conductive material, to ensure it will safely attach to nerve tissue and conduct gentle electric currents. I measure impedance—the material’s resistance to electrical flow—using electrochemical impedance spectroscopy (EIS) to assess stability. Additionally, I use direct current stimulation on graphene electrodes over extended periods to confirm that the electrical current is safe for biological systems. Each step brings me closer to making these cuff electrodes a reality.
What do you see as the impact—or potential impact—of your work?
My project on graphene-based nerve cuff electrodes could eventually support nerve regeneration, offering potential solutions for patients with spinal cord injuries by restoring lost functions. In particular, one of my goals is to improve access to low-cost, effective bioelectronic devices, which could lead to broader availability of medical technologies.
I find it incredibly exciting to contribute to pioneering medical research that could lead to affordable, accessible health-care solutions. The prospect of my work improving the quality of life for others is a major motivator for me.
How does your faculty mentor support your research?
Professor Kireev provides me with continuous guidance and resources, fostering a collaborative and welcoming research environment. This supportive setting has been instrumental in my personal and professional growth, helping me develop key skills in data analysis and team collaboration.
What do you find most exciting about your research?
I find it incredibly exciting to contribute to pioneering medical research that could lead to affordable, accessible health-care solutions. The prospect of my work improving the quality of life for others is a major motivator for me.
What are you most proud of?
I’m particularly proud of my co-authored publication in Device (a Cell Press journal) on squishy bioelectronics. This work was also featured on the UMass news website for its innovative approach to accessible bioelectronic devices.
How has your research enhanced your overall educational experience at UMass?
My research experience has been pivotal in enhancing my education [as I bridge] theoretical
learning with hands-on lab work. Working in a diverse, interdisciplinary team has
broadened my perspective and reinforced my commitment to inclusive and impactful
research.
What are your plans for the future?
I am deeply inspired by the work and the environment in the Kireev lab, and I have decided that I would like to continue research in the future, either in academia or in industry. After graduating from UMass, I plan to pursue graduate studies to further my education in biomedical engineering.
Why would you recommend UMass to a friend?
I would recommend UMass for its commitment to cutting-edge academic research, its strong and effective mentoring environment, and its focus on real-world applications, particularly in biomedical engineering. The opportunity to work on meaningful projects with supportive faculty and peers has been invaluable to my educational journey.