Jie Song

With an aging population, the demand for synthetic tissue scaffolds assisting the regenerative reconstruction of skeletal defects resulting from trauma, cancer and metabolic diseases is rising. Our lab is interested in 1) designing functional synthetic matrices to guide bone and cartilage tissue regeneration; 2) identifying and implementing novel strategies for modulating synthetic niche properties as means to regulate stem cell fate; 3) improving osteointegration of and reducing periprosthetic infections associated with orthopedic metallic implants. Many of the synthetic matrices we designed are programmed with unique physical properties to facilitate surgical delivery (injectable formulations; minimally invasive delivery, and stable in vivo fixation), predictive in vivo degradation profiles, tunable biomechanical cues, and spatially controlled presentation and temporally controlled release of bioactive factors for regulating fate of stem/progenitor cells within the synthetic niche.

See UMass Chan Medical School faculty profile for additional information.