
Shedding New Light on Fundamental Brain Processes
Sarah DeAmicis '25
Medical Neurobiology (Bachelor's Degree with Individual Concentration) and Psychology
Leominster, Massachusetts
What drew you to this field of study?
In high school, I was initially drawn to medicine and biology, and I became an emergency medical technician during my senior year. During my time treating patients with neurological emergencies, one fact quickly became apparent to me: Modern neuroscience is still in its infancy. Dysfunction of most organs can be traced to specific biological indicators; however, brain dysfunction is typically diagnosed through changes in behavior and cognition, not physical markers. This fact sparked my interest in the inner workings of the brain and seeking to improve our understanding of the most complex organ in the body. The biological challenges and ethical complexities associated with brain disorders further drew me to the field.
How do you conduct your research?
I reconstruct brain cells—called neurons—in a model organism using advanced 3D modeling techniques. My research utilizes a set of high-resolution electron microscopy images taken from the brain of sea slug Berghia stephanieae, which contains large, identifiable neurons. Using state-of-the-art software, I trace (“segment”) specific brain cells through each image of the dataset, then compile the segmentations to create a 3D cell structure. Reconstructing single cells shows physical properties like shape, synaptic connections, and neighboring cell interactions—qualities that predict their activity in live brains. In addition to modeling single cells, I perform dense reconstructions, in which I reconstruct all structures within a defined region. This method allows me to more closely assess the morphology of axons, dendrites, and glial cells, the “support” cells of nervous systems.
What do you see as the impact—or potential impact—of your work?
The novel discoveries I’ve made provide physical evidence for fundamental brain processes, and my upcoming publication will contribute to the growing body of literature in this field. Alterations in neurons, synapses, and glial cells are central to various neurodegenerative and neurodevelopmental diseases, including Alzheimer’s disease, multiple sclerosis, and cerebral palsy. By clarifying the structural basis of interactions among these cells, my research will inform new approaches to the diagnosis and treatment of these debilitating disorders, which represent significant public health challenges.
Nothing compares to the thrill of a novel discovery, and that unique moment shared between you, your finding, and its potential impact.
How does your faculty mentor support your research?
My faculty mentor, Professor of Biology Paul Katz, has supported me in every way possible. Since I joined the lab as a freshman, I’ve been encouraged to ask questions and become an active participant. The collaborative environment fostered in the Katz Lab made a critical impact on my research experience, connecting me with fellow undergraduate researchers and my amazing postdoctoral mentor, Harshada Sant. Through the support and guidance of my mentors, I have been able to design my own research plans, present my work at state and national conferences, and collaborate with faculty from partner labs. Professor Katz has inspired me to push myself beyond my comfort zone, and I’m incredibly grateful for my experience in undergraduate research.
What do you find most exciting about your research?
Nothing compares to the thrill of a novel discovery, and that unique moment shared between you, your finding, and its potential impact. Despite the countless hours of experimental setbacks, troubleshooting, and literature searches, I’m motivated by the fact that my research could one day make a meaningful difference in someone’s life. It’s especially exciting to know that I’m joining the long line of scientists whose discoveries laid the groundwork for my own research today.
What are you most proud of?
I’m most proud of my growth into a confident researcher and leader. When I first joined the lab as one of the youngest members, I was intimidated by the overwhelming amount of knowledge I had yet to gain. Over time, I proved to myself that with consistent dedication and effort, I was capable of reaching the level of senior students, which strengthened my motivation to succeed. Today, I serve as the undergraduate leader on projects moving toward publication, develop protocols to streamline our workflow, and train new students in the essential aspects of our research process. Most importantly, I am proud to carry forward the Katz Lab tradition of creating a supportive, welcoming environment for all new team members.
How has your research enhanced your overall educational experience at UMass?
Conducting research as an undergraduate has shaped every aspect of my educational journey. My experience at UMass has opened up exciting opportunities, including stem cell research at the University of Copenhagen and functional MRI research at Smith College. Research also enhanced my role as a tutor for student-athletes, where the communication skills I gained through presenting my work enabled me to deliver clearer, more effective instruction in STEM subjects. Ultimately, my research experience inspired me to join UMass’s Bachelor’s Degree with Individual Concentration (BDIC) program, where I designed a unique interdisciplinary major in medical neurobiology. As my research evolved, so did my curriculum, allowing me to build a strong theoretical and practical foundation in neuroscience.
What are your plans for the future?
My research experience has solidified my commitment to graduate studies in neuroscience, where I aim to deepen my understanding of human brain structure and function. After graduating from UMass Amherst this spring, I plan to take a working gap year to join leading neuroscience research at hospitals and institutions in the Boston area. Following this, I intend to pursue graduate school to specialize in neurodegenerative disorders like frontotemporal dementia and Alzheimer’s disease. With the practical and theoretical expertise I gain, I aim to bridge the gap between research and health care, advancing diagnostic and treatment methods for devastating brain diseases.
Why would you recommend UMass to a friend?
UMass Amherst has provided me with the tools and opportunities to succeed academically, professionally, and personally. UMass provides many opportunities for undergraduate students to become involved in research, especially through their equitable application processes, ample funding opportunities, and impressive facilities. The excellent guidance of UMass faculty and advisors also granted me the opportunity to design my own major and enroll in specialized courses at partner institutions. Most importantly, there’s a place for everyone here; although we’re a large school, the connections you build within your UMass communities will make a meaningful difference in your social and academic experience.