Current research in my laboratory aims at:
1) understanding the cellular and molecular mechanisms underlying mammalian oocyte meiosis, activation, and aging;
2) discovering novel genes, factors, and signaling pathways that are functionally required during mammalian preimplantation embryo development;
3) creating animal models of human genetic diseases using knock-out, knock-in, and transgenesis strategies.
Learn more at umass.edu/m2m/people/wei-cui
Animal Models core facility provides transgenic, gene targeting, and other services to the research community. The core performs microinjections of DNA into fertilized embryos to generate transgenic mice. Uses cutting-edge technologies, including CRISPR/Cas9 genome editing, to generate gene knock-out or knock-in mice or other animal models. In addition, provides mouse surgery service and training, such as patient-derived xenograft (PDX), tail vein injection, and catheterization. The core is able to customize services as requested to support development of animal models of human diseases in a timely and cost-efficient manner.
Learn more at umass.edu/ials/animal-models