Bioproduction / Separation

The lab has five 500 mL MiniBio bioreactors that represents a scale down model of laboratory bioreactors. The MiniBio systems have the same flexibility and controls as the laboratory scale bioreactors. This means that the MiniBio systems can be customized to fit the demands of any process. The small volume reduces medium costs and reduces the use of expensive bench space. These small units are perfect for:

• Screening studies
• Media optimization
• Process optimization
• Microbial and Cell culture

The lab has a 3L and a 15L bioreactor controlled by Applikon’s ez controllers. The ez-Control is an easy to use system for bioreactors and fermenters that accurately controls for pH, temperature, Dissolved Oxygen (DO), Foam/Level and Agitation. The color touch screen interface guides the user through the operation. The adaptive control features allow the user to focus on the process while the controller keeps tight control on the important process parameters.

The lab has a Thermo Scientific™ Sorvall™ LYNX 6000 Superspeed Centrifuge for high-speed separations. The Lynx has a maximum speed of 29,000 rpm (100k xg) with a temperature range of -20 to 40°C. There are 2 fixed angle carbon fiber rotors that allow volumes from 14x50 mL conical tubes up to 6x1 liter to be processed. A swinging bucket rotor allows for up to 4x1 L volumes.

ÄKTA pure is a flexible and intuitive chromatography system for fast purification of proteins, peptides, and nucleic acids from microgram to gram levels of target product.

• Modular system design with a large range of options to allow flexibility in purification of proteins and peptides.
• Customizable system that is easy to upgrade as your research needs develop.
• Reliable system with components and integrated features based on the proven design of ÄKTA avant.
• UNICORN software simplifies your work by providing simple, intuitive, and flexible total system control including drag-and-drop method creation.
• Predefined method settings for all GE Healthcare lab-scale chromatography columns.

The single-use ReadyToProcess WAVE 25 bioreactor system is a reliable and intuitive cell culture device for working volumes in the 0.3 to 25 L range. Designed to meet the demands of a regulated environment, the system offers reliable performance, accurate process control, and ease-of-use.

The ReadyToProcess WAVE 25 system consists of a rocker (ReadyToProcess WAVE 25 Rocker), control units (ReadyToProcess CBCU), and pumps (ReadyToProcess Pump 25), all operated by UNICORN software installed on a client computer.