S. Thai Thayumanavan

Sankaran Thayumanavan

Department of Chemistry
Department of Biomedical Engineering
Physical Sciences Building, 273
North Pleasant Street
Amherst, MA 01003

(413) 545-1313
thai@umass.edu 
www.umass.edu/chemistry/about/directory/s-thai-thayumanavan

Director of the Center for Bioactive Delivery

Department Head, Biomedical Engineering
Distinguished Professor, Biomedical Engineering
Distinguished Professor, Chemistry

We are interested in the design and syntheses of macromolecules that are inspired by specific applications that our group is interested in or by the sheer beauty of the structures that one can generate using novel supramolecular design principles as a tool box. The structures that we imagine are often inspired by the intricacies of the nature’s supramolecular assemblies involving proteins, lipids and nucleic acids.

Current Research
Nanoassemblies that predictably respond to an external stimulus or a combination of stimuli are of great interest, because of their implications in a rather broad range of applications. The primary design challenge concerns two factors: input (stimulus or stimuli) and output (response). For example, one could design materials that are responsive to pH changes, yielding a response in the form of a molecular release. The ability to tailor the molecular design to achieve materials that respond to a broad range of inputs, yielding a broad range of outputs has significant implications in a variety of areas. When focusing on an application, although our primary design will provide the fundamental structure-property relationship handles, secondary design challenges emerge. In drug delivery, for example, the molecular design needs to account for factors such as encapsulation stability, drug loading capacity, and biocompatibility. Within drug delivery, there are tertiary design challenges, dictated by the specific disease targeted. In our group, we are focused on developing generalized principles that underlie responsive molecular assemblies and the resultant materials. By addressing the primary design challenge, we have developed and are developing capabilities to tackle a broad range of challenges including drug delivery, diagnostics, and sensing. Prominent examples of materials developed in our group for this purpose include a novel self-crosslinking polymeric nanogel for drug delivery and kinetically-trapped amphiphilic homopolymers for sensing in complex milieu.

Learn more at Thayumanavan Research Group

Academic Background

BSc The American College, India, 1987
MSc The American College, India, 1989
PhD University of Illinois, 1996
Postdoctoral training: Caltech, 1996-99

  • Center for Bioactive Delivery 
  • CBD Leadership 
  • CBD Steering Committee 
  • Models to Medicine Center 
  • Biomaterials for Devices and Regenerative Medicine (BDRM) 
  • Cellular Dynamics 
  • Nucleic Acid Delivery 
  • Proteins, Peptides & Antibodies 
  • Small Molecule Delivery & Nutraceuticals