Alexander Suvorov

Aging is the single greatest cause of morbidity and mortality worldwide, yet there are currently no approved interventions that directly target aging mechanisms to extend human healthspan and lifespan. Progress toward such therapies is limited by incomplete understanding of the evolutionary and molecular drivers of aging.

To close these gaps, we pursue theoretical research to refine evolutionary models of aging and use those insights to identify molecular targets for longevity interventions. For example, guided by predictions from the stochastic epigenetic variation hypothesis, we identified molecular mechanisms underlying epigenetic aging in sperm and showed that exposures to chemical pollutants and other stressors reprogram the sperm epigenome and negatively affect offspring health via acceleration of epigenetic aging. These findings open therapeutic avenues for rejuvenating male reproductive health and for mitigating transgenerational effects on offspring.

My group also investigates the relative contributions of damage accumulation versus developmental (quasi‑program) processes to aging. We combine experiments in laboratory organisms, bioinformatic analyses of large datasets, and theoretical modeling to test these mechanisms and identify the diversity of aging modalities among animal species.

Publication List: 

• NCBI Bibliography