Kari D. Loomis

Research Interests: 

Cancer Genetics/ Cell signaling/ cell cycle regulation

My doctoral research focused on the characterization of the transcription factor C/EBPα as a tumor suppressor in epithelial tissues using a tissue specific transgenic mouse model.  After earning my doctorate, I went on to teach as an Assistant professor of Biology in two small liberal arts colleges where my research focus shifted to the exploration of food as both a cause and a cure for cancers.  I wrote grants and worked with undergraduates to create mammalian cell culture labs where we grew human breast cancer cells in culture and treated them with acai berry, strawberry, and blueberry extracts.  We found all of the fruit extracts to promote apoptosis and inhibit proliferation in the cancer cells, but not in the normal cells. At UMass, my research is primarily classroom based. I have designed and am implementing a new Genetics Laboratory course (Biology 284) that is planned to become a requirement for all Biology Majors. In the Genetics lab we explore the relationship between genotype and phenotype at the molecular and organismal level by analyzing the DNA from various dogs including students’ own dogs if they are interested and predicting traits such as height, snout length, excitability, trainability, and hair length using a technique similar to RFLP. To further explore the nature of phenotypic variation within and between species and to compare evolutionary relatedness of a gene between species, we sequence the MC1R gene involved in pigmentation and align the MC1R sequence results from the various dogs with one another and with the sequences of various other species such as the wolf, fox, coyote, woolly mammoth, and humans.