Bridget Twombly '24

2024

Biomedical Engineering

RCSI StAR PhD Programme

Fall 2024-Spring 2028

Ireland 

My project is looking for tissue engineering solutions to post traumatic osteoarthritis (PTOA) by first using in vitro models to study how damage to subchondral bone cells (caused during knee injury) can evoke inflammatory responses. This inflammatory response communicates via a bone-cartilage crosstalk mechanism to drive cartilage degeneration. I will also evaluate a drug candidate that blocks a step in this process as an early intervention treatment to prevent PTOA.