Sang Hyun Lee

Chemical and Biological Engineering, Seoul National University, 2017

Microbial habitats are frequently characterized by fluid flow. In Dr. Lee’s laboratory, we explore the intricate dynamics of microbe-fluid interactions across diverse environments ranging from natural, engineering, and clinical systems. Using cutting-edge tools such as microfluidics (Lab-on-a-chip), confocal laser scanning microscopy, and numerical simulations, we aim to enhance our fundamental understanding of microbe-fluid interactions. Moreover, we are interested in translating these insights into practical solutions by developing innovative biotechnologies (e.g., bioremediation, anti-biofilm tech), demonstrated at larger scales.

Biofilm formation in porous media:

Biofilms can significantly impact fluid flow, leading to challenges such as clogging in water treatment filters, alterations in groundwater flow, and microbial infections. Conversely, flow shear and channel geometry can influence cell attachment, biofilm growth, and nutrient transport, which in turn affect flow dynamics. Our research delves into the complex interplay between fluid flow and microbial activity. We investigate how these factors mutually influence each other, leading to changes in flow paths, solute distribution, and reactions within porous media systems. From this, we aim to deepen our fundamental understanding on biofilm formation in porous media and develop technology that can control and engineer biofilm formation.

Bioengineering for sustainability:

Microbes play a crucial role in various engineering processes, including wastewater treatment, bioremediation, and bioenergy production—processes essential for environmental protection and sustainable energy generation. Our research focuses on understanding these microbial processes at the microscale, utilizing micro- and milli-fluidic chips, and at the laboratory scale, using soil columns and bioreactors. We aim to translate these findings into real-world applications, scaling up to larger systems that can be implemented in industrial settings. By bridging the gap between laboratory research and practical applications, our work contributes to addressing global challenges such as climate change, resource sustainability, and environmental preservation.