U.S. Veterinary Immune Reagent Network

Cattle

Recombinant proteins have been made for the following genes: CCL2, CCL5, CCL11, CXCL9, CXCL10, CXCL11, IFN-γ, IFN-α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-13, IL-15, IL-17, IL-23A, TNF-α
Recombinant proteins will be made for the following genes:
IFN-β, IL-5, IL-7, IL-10, IL-12p35, IL-12p40, IL-18,

Monoclonals antibodies will be made to the:

Cell Surface Molecules:

TCRγ: fusion completed September 2008; 3 mAbs,contact Dr. Cynthia Baldwin, UMass Amherst about monoclonals.

CCR7: protein produced;several mAbs produced; screening and characterization ongoing 2013(UMass Amherst).

Cytokines and Chemokines:

CCL2: fusion completed with yeast-expressed protein 2012; two mAbs identified (9F5 and 22F1) which also cross react with swine (both), canine (both), and equine (9F5) CCL2; characterization ongoing 2013 (U Mass Amherst) .

IL-13: fusion completed Decemeber 2008; mAbs lost specificity;mammlian expressed protein produced (UMass Amherst); sseveral mAbs identified; characterization ongoing (U Mass Amherst).

IFNα: protein production scheduled December 2008 (Kingfisher);mammalian expressed protein produced (UMass Amherst); fusion failed; re-immunizations in progress 2013 (U Mass Amherst).

IL-17A: protein production scheduled Spring 2010 (Kingfisher); mammalian expressed proteins produced(UMass Amherst); several mAbs to IL-17A and IL-17F prouced; characterization ongoing 2013 (U Mass Amherst).
IL-17F: protein production scheduled Spring 2010 (Kingfisher); mammalian expressed proteins produced(UMass Amherst); several mAbs produced; characterization ongoing 2013 (U Mass Amherst).

IL-6: protein scheduled April 2009 (Kingfisher); mammalian expressed proteins produced (UMass Amherst); several mAbs identified; characterizations ongoing 2013 (U Mass Amherst).

Click here to download the survey form.
Then fill it out, and send it back to the appropriate species coordinator.

Last updated: March 2013