Richard A. Goldsby

Richard A. Goldsby

Adjunct Professor of Veterinary & Animal Sciences

Professor of Biology, Amherst College

Office: 

427F ISB

Office phone: 

413-542-8084

Ph.D.: University of California at Berkeley, 1961
Honors: John Woodruff Simpson Lectureship

Classes: 

Classes:
ANIML SCI 572 - Infection and Immunity
ANIML SCI 697K - Advanced Immunology
 


 

Research Interests

Somatic Hypermutation of Immunoglobulin Genes; Immunoglobulin Diversification in Cattle

Diversity is the hallmark of the immune system and somatic mutation generates significant antibody diversity in a number of species including humans, rodents, and cattle. The mechanism responsible for the somatic hypermutation of antibody genes remains one of the unsolved problems of immunology. Work in my laboratory is directed toward the establishment of cell culture systems that will allow the observation and analysis of this process in vitro. Because the ileal Peyer’s patch (IPP) of cattle is the site of massive (involving up to >1X10E11 B cells) developmentally regulated, extensive somatic diversification of antibody genes, it is a principal target of our studies. In collaboration with the Osborne laboratory, we conduct a continuing program to understand the basic mechanisms of antibody diversification in ruminants and to characterize the bovine immunoglobulin heavy and light immunoglobulin loci.

Publications

Tonomura, N., McLaughlin, K., Grimm, L., Goldsby, R. A., & Osborne, B. A.. (2003). Glucocorticoid-induced apoptosis of thymocytes: requirement of proteasome-dependent mitochondrial activity. Journal of immunology (Baltimore, Md. : 1950), 170(5), 2469-78. presented at the 2003 Mar 1.
Jeong, Y., Osborne, B. A., & Goldsby, R. A.. (2001). Early Vlambda diversification in sheep. Immunology, 103(1), 26-34. presented at the 2001 May.
Lucier, M. R., Thompson, R. E., Waire, J., Lin, A. W., Osborne, B. A., & Goldsby, R. A.. (1998). Multiple sites of V lambda diversification in cattle. Journal of immunology (Baltimore, Md. : 1950), 161(10), 5438-44. presented at the 1998 Nov 15.
Meyer, A., Parng, C. L., Hansal, S. A., Osborne, B. A., & Goldsby, R. A.. (1997). Immunoglobulin gene diversification in cattle. International reviews of immunology, 15(3-4), 165-83. presented at the 1997.
McLaughlin, K. A., Osborne, B. A., & Goldsby, R. A.. (1996). The role of oxygen in thymocyte apoptosis. European journal of immunology, 26(5), 1170-4. presented at the 1996 May.
Parng, C. L., Hansal, S., Goldsby, R. A., & Osborne, B. A.. (1996). Gene conversion contributes to Ig light chain diversity in cattle. Journal of immunology (Baltimore, Md. : 1950), 157(12), 5478-86. presented at the 1996 Dec 15.
Osborne, B. A., Smith, S. W., McLaughlin, K. A., Grimm, L., Morgan, G., & Goldsby, R. A.. (1996). Genetic regulation of apoptosis in the mouse thymus. Advances in experimental medicine and biology, 406, 199-207. presented at the 1996.
Parng, C. L., Hansal, S., Goldsby, R. A., & Osborne, B. A.. (1995). Diversification of bovine lambda-light chain genes. Annals of the New York Academy of Sciences, 764, 155-7. presented at the 1995 Sep 29.
Ravichandran, K. S., Semproni, A. R., Goldsby, R. A., & Osborne, B. A.. (1992). Immunoglobulin VH usage analysis by fluorescent in situ hybridization and flow cytometry. Journal of immunological methods, 153(1-2), 249-59. presented at the 1992 Aug 30.
Lin, A. W., Goldsby, R. A., & Snoeyenbos, G. H.. (1992). Salmonella enteritidis-specific monoclonal antibodies. Avian diseases, 36(2), 455-8. presented at the 1992 Apr-Jun.