|Title||Protein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Samanta, B, Yan, H, Fischer, NO, Shi, J, D Jerry, J, Rotello, VM|
|Journal||J Mater Chem|
Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.
|Alternate Journal||J Mater Chem|
Veterinary and Animal Sciences