Potential contribution of insecticide exposure and development of obesity and type 2 diabetes.

TitlePotential contribution of insecticide exposure and development of obesity and type 2 diabetes.
Publication TypeJournal Article
Year of Publication2017
AuthorsXiao, X, Clark, JM, Park, Y
JournalFood Chem Toxicol
Volume105
Pagination456-474
Date Published2017 Jul
ISSN1873-6351
KeywordsAnimals, Diabetes Mellitus, Type 2, Environmental Exposure, Humans, Insecticides, Obesity
Abstract

The introduction of insecticides has greatly improved agricultural productivity and human nutrition; however, the wide use of insecticides has also sparked growing concern over their health impacts. Increased rate of cancers, neurodegenerative disorders, reproductive dysfunction, birth defects, respiratory diseases, cardiovascular diseases and aging have been linked with insecticide exposure. Meanwhile, a growing body of evidence is suggesting that exposure to insecticides can also potentiate the risk of obesity and type 2 diabetes. This review summarizes the relationship between insecticide exposure and development of obesity and type 2 diabetes using epidemiological and rodent animal studies, including potential mechanisms. The evidence as a whole suggests that exposure to insecticides is linked to increased risk of obesity and type 2 diabetes.

DOI10.1016/j.fct.2017.05.003
Alternate JournalFood Chem Toxicol
PubMed ID28487232
PubMed Central IDPMC5518693
Grant ListR21 ES023676 / ES / NIEHS NIH HHS / United States