New chemistries for the control of human head lice, Pediculus humanus capitis: A mini-review.

TitleNew chemistries for the control of human head lice, Pediculus humanus capitis: A mini-review.
Publication TypeJournal Article
Year of Publication2022
AuthorsClark, JM
JournalPestic Biochem Physiol
Date Published2022 Feb
KeywordsAnimals, Humans, Insecticides, Lice Infestations, Pediculus

Pediculus lice represent one of the longest and most prevalent parasitic infestations of humans. Head lice are an economic and social concern whereas body lice pose a more serious public health threat. Significant progress has been made in the study of human lice over the last 10 years, allowing for new approaches in their control. An in vitro rearing system has made it possible to maintain insecticide-susceptible and -resistant reference strains, which allowed an in depth study of pediculicide resistance, including its underlying molecular mechanisms and the detection and monitoring of resistance. The generation of inbreed strains facilitated the efficient sequencing, assembly and annotation of the genomes and transcriptomes of both lice. The use of functional genomics and reverse genetics elucidated the genetics involved in the evolution of resistance and the discovery of novel target sites for the development of new pediculicides. In this review, four new effective pediculicide products, each with different mode of action and unique chemistries, will be presented. They have been found to be safe and selective, and control resistant lice. As such, they meet the criteria necessary to be used in rotations as a sustainable resistance management strategy.

Alternate JournalPestic Biochem Physiol
PubMed ID35082036
PubMed Central IDPMC8795694
Grant ListR01 AI045062 / AI / NIAID NIH HHS / United States
R56 AI081933 / AI / NIAID NIH HHS / United States