| Title | Neurotoxic implications of the agonistic action of CS-syndrome pyrethroids on the N-type Ca(v)2.2 calcium channel. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | J Clark, M, Symington, SB |
| Journal | Pest management science |
| Volume | 64 |
| Issue | 6 |
| Pagination | 628-38 |
| Date Published | 2008 Jun |
| Abstract | Cismethrin (T-syndrome) and deltamethrin (CS-syndrome) pyrethroids have been previously shown to increase membrane depolarization and calcium influx, but only deltamethrin increased Ca(2+)-dependent neurotransmitter release from rat brain synaptosomes. Deltamethrin's action was blocked by omega-conotoxin GVIA, delineating a separate action at N-type Ca(v)2.2 channels that is consistent with the in vivo release of neurotransmitter. It is hypothesized that other CS-syndrome pyrethroids will elicit similar actions at presynaptic nerve terminals. |
| Alternate Journal | Pest Manag. Sci. |
Veterinary and Animal Sciences