Title | Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Li, C-H, Landis, RF, Makabenta, JMarie, Nabawy, A, Tronchet, T, Archambault, D, Liu, Y, Huang, R, Golan, M, Cui, W, Mager, J, Gupta, A, Schmidt-Malan, S, Patel, R, Rotello, VM |
Journal | Mater Horiz |
Volume | 8 |
Issue | 6 |
Pagination | 1776-1782 |
Date Published | 2021 06 01 |
ISSN | 2051-6355 |
Keywords | Animals, Anti-Bacterial Agents, Anti-Infective Agents, Bacterial Infections, Biofilms, Mice, Wound Infection |
Abstract | Bacterial wound infections are a threat to public health. Although antibiotics currently provide front-line treatments for bacterial infections, the development of drug resistance coupled with the defenses provided through biofilm formation render these infections difficult, if not impossible, to cure. Antimicrobials from natural resources provide unique antimicrobial mechanisms and are generally recognized as safe and sustainable. Herein, an all-natural antimicrobial platform is reported. It is active against bacterial biofilms and accelerates healing of wound biofilm infections . This antimicrobial platform uses gelatin stabilized by photocrosslinking using riboflavin (vitamin B) as a photocatalyst, and carvacrol (the primary constituent of oregano oil) as the active antimicrobial. The engineered nanoemulsions demonstrate broad-spectrum antimicrobial activity towards drug-resistant bacterial biofilms and significantly expedite wound healing in an murine wound biofilm model. The antimicrobial activity, wound healing promotion, and biosafety of these nanoemulsions provide a readily translatable and sustainable strategy for managing wound infections. |
DOI | 10.1039/d0mh01826k |
Alternate Journal | Mater Horiz |
PubMed ID | 34594564 |
PubMed Central ID | PMC8478344 |
Grant List | R01 AI134770 / AI / NIAID NIH HHS / United States |
Veterinary and Animal Sciences