Immunomodulatory effects of coated gold nanoparticles in LPS-stimulated and murine model systems.

TitleImmunomodulatory effects of coated gold nanoparticles in LPS-stimulated and murine model systems.
Publication TypeJournal Article
Year of Publication2016
AuthorsMoyano, DF, Liu, Y, Ayaz, F, Hou, S, Puangploy, P, Duncan, B, Osborne, BA, Rotello, VM
JournalChem
Volume1
Issue2
Pagination320-327
Date Published2016
ISSN2451-9294
Abstract

The ability of nanoparticle surface functionalities to regulate immune responses during an immunological challenge (i. e. inflammation) would open new doors for their use in non-prophylactic therapeutics. We report here the use of functionalized 2 nm core gold nanoparticles to control the immunological responses of and systems presented with an inflammatory challenge. The results showed that NPs bearing a hydrophobic zwitterionic functionality boost inflammatory outcomes while hydrophilic zwitterionic NPs generate minimal immunological responses. Surprisingly, tetra(ethylene glycol) headgroups generate a significant anti-inflammatory response both and . These results demonstrate the ability of simple surface ligands to provide immunomodulatory properties, making them promising leads for the therapeutic usage of nanomaterials in diseases involving inflammation.

DOI10.1016/j.chempr.2016.07.007
Alternate JournalChem
PubMed ID28255579
PubMed Central IDPMC5328597
Grant ListP01 CA166009 / CA / NCI NIH HHS / United States
R01 GM077173 / GM / NIGMS NIH HHS / United States
T32 GM108556 / GM / NIGMS NIH HHS / United States