TY - JOUR T1 - Regulation of cancer stem cells by p53. JF - Breast Cancer Res Y1 - 2008 A1 - Jerry, D Joseph A1 - Tao, Luwei A1 - Yan, Haoheng KW - Animals KW - Gene Expression Regulation, Neoplastic KW - Genes, p53 KW - Humans KW - Mice KW - Mice, Inbred BALB C KW - Models, Biological KW - Mutation KW - Neoplastic Stem Cells KW - Phenotype KW - Tumor Suppressor Protein p53 AB -

The hypothesis that cancer stem cells are responsible for the chemoresistant and metastatic phenotypes of many breast cancers has gained support using cell-sorting strategies to enrich the tumor-initiating population of cells. The mechanisms regulating the cancer stem cell pool, however, are less clear. Two recent publications suggest that loss of p53 permits expansion of presumptive cancer stem cells in mouse mammary tumors and in human breast cell lines. These results add restriction of cancer stem cells as a new tumor suppressor activity attributed to p53.

VL - 10 IS - 4 U1 -

http://www.ncbi.nlm.nih.gov/pubmed/18828866?dopt=Abstract

ER -