TY - JOUR T1 - Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice. JF - Breast cancer research : BCR Y1 - 2008 A1 - Dunphy, Karen A A1 - Blackburn, Anneke C A1 - Yan, Haoheng A1 - O'Connell, Lauren R A1 - Jerry, D Joseph AB -

Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome.

VL - 10 IS - 3 U1 - http://www.ncbi.nlm.nih.gov/pubmed/18471300?dopt=Abstract ER -