|Title||Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Dunphy, KA, Blackburn, AC, Yan, H, O'Connell, LR, D Jerry, J|
|Journal||Breast cancer research : BCR|
Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome.
|Alternate Journal||Breast Cancer Res.|
Veterinary and Animal Sciences