| Title | Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Dunphy, KA, Blackburn, AC, Yan, H, O'Connell, LR, D Jerry, J |
| Journal | Breast cancer research : BCR |
| Volume | 10 |
| Issue | 3 |
| Pagination | R43 |
| Date Published | 2008 |
| Abstract | Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome. |
| Alternate Journal | Breast Cancer Res. |
Veterinary and Animal Sciences