Title | Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Dunphy, KA, Blackburn, AC, Yan, H, O'Connell, LR, D Jerry, J |
Journal | Breast cancer research : BCR |
Volume | 10 |
Issue | 3 |
Pagination | R43 |
Date Published | 2008 |
Abstract | Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome. |
Alternate Journal | Breast Cancer Res. |
Veterinary and Animal Sciences