ADAM function in embryogenesis.

TitleADAM function in embryogenesis.
Publication TypeJournal Article
Year of Publication2009
AuthorsAlfandari, D, McCusker, C, Cousin, H
JournalSeminars in cell & developmental biology
Date Published2009 Apr

Cleavage of proteins inserted into the plasma membrane (shedding) is an essential process controlling many biological functions including cell signaling, cell adhesion and migration as well as proliferation and differentiation. ADAM surface metalloproteases have been shown to play an essential role in these processes. Gene inactivation during embryonic development have provided evidence of the central role of ADAM proteins in nematodes, flies, frogs, birds and mammals. The relative contribution of four subfamilies of ADAM proteins to developmental processes is the focus of this review.

Alternate JournalSemin. Cell Dev. Biol.