|Title||ADAM function in embryogenesis.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Alfandari, D, McCusker, C, Cousin, H|
|Journal||Seminars in cell & developmental biology|
|Date Published||2009 Apr|
Cleavage of proteins inserted into the plasma membrane (shedding) is an essential process controlling many biological functions including cell signaling, cell adhesion and migration as well as proliferation and differentiation. ADAM surface metalloproteases have been shown to play an essential role in these processes. Gene inactivation during embryonic development have provided evidence of the central role of ADAM proteins in nematodes, flies, frogs, birds and mammals. The relative contribution of four subfamilies of ADAM proteins to developmental processes is the focus of this review.
|Alternate Journal||Semin. Cell Dev. Biol.|