Kathleen F. Arcaro
Professor
ABBS Graduate Program Director
she, her, hers
Office:
N529 LSL
Mailing address:
University of Massachusetts
240 Thatcher Road
LSL 1 Room N529
Amherst, MA 01003-9298
Office phone:
413-577-1823
Email:
Ph.D.: Rutgers University, 1987
Postdoctoral Training:
University at Albany
Wadsworth Laboratories,
New York State Department of Health
Awards: CNRE Achievement Award for Outstanding Teaching
Classes:
ANIMLSCI 386 - Veterinary Oncology Laboratory
Research Interests
Breast Cancer
Assessing Individual Breast Cancer Risk
The vast majority of breast cancers are sporadic, yet current risk assessment tools do not identify individual risk. A major goal of the research in the Arcaro lab is to develop tools for assessing individual breast cancer risk. To this end, we study breastmilk. Human milk contains multiple cell types, including epithelial cells from the lining of the ducts and lobules. Because cancer-related DNA methylation may occur decades before disease diagnosis, we are interested in determining the extent to which DNA methylation patterns in the sloughed epithelial cells can inform future breast cancer risk. Accurately assessing individual risk would provide women the opportunity to make informed decisions regarding preventative treatments.
Lab Personnel
| Name | Phone | Office | |
|---|---|---|---|
|
Baker, Ryan L. Graduate Student - ABBS |
rlbaker [at] umass.edu | 413-545-0813 | LSL 540D |
|
Browne, Eva Research Associate |
ebrowne [at] vasci.umass.edu | 413-545-0813 | LSL N261 |
|
Taylor, Rachel Research Technician |
rytaylor [at] umass.edu | 413-545-0813 | LSL 540D |
Publications
. (2022). Durable antibody and effector memory T cell responses in breastmilk from women with SARS-CoV-2. Front Immunol, 13, 985226. presented at the 2022. doi:10.3389/fimmu.2022.985226
. (2022). New Moms Wellness Study: trial study protocol for an intervention study to increase fruit and vegetable intake and lower breast cancer risk through weekly counseling and supplemental fruit and vegetable box delivery in breastfeeding women. BMC Womens Health, 22(1), 389. presented at the 2022 09 24. doi:10.1186/s12905-022-01967-9
. (2022). Neutralizing Antibodies and Cytokines in Breast Milk After Coronavirus Disease 2019 (COVID-19) mRNA Vaccination. Obstet Gynecol, 139(2), 181-191. presented at the 2022 02 01. doi:10.1097/AOG.0000000000004661
. (2021). Humoral and Cell-Mediated Immune Response in Colostrum from Women Diagnosed Positive for SARS-CoV-2. Breastfeed Med, 16(12), 987-994. presented at the 2021 12. doi:10.1089/bfm.2021.0082
. (2021). Prediagnostic White Blood Cell DNA Methylation and Risk of Breast Cancer in the Prostate Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort. Cancer Epidemiol Biomarkers Prev, 30(8), 1575-1581. presented at the 2021 08. doi:10.1158/1055-9965.EPI-20-1717
. (2020). Inter-Individual Variation in Response to Estrogen in Human Breast Explants. Journal of Mammary Gland Biology and Neoplasia, 25, 51–68. Retrieved from https://doi.org/10.1007/s10911-020-09446-3
. (2020). Effects of Two Types of Calorie Restriction on Methylation Levels of Adiponectin Receptor 1 (AdipoR1) and Leptin Receptor Overlapping Transcript (Leprot) in a MMTV-TGF-a Breast Cancer Mouse Model. British Journal of Nutrition, 123, 1079–1079. Retrieved from https://doi.org/10.1017/s0007114520000471
. (2020). Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization. Epigenetics, 15, 1093–1106. Retrieved from https://doi.org/10.1080/15592294.2020.1747748
. (2020). Polymeric nanoassemblies for enrichment and detection of peptides and proteins in human breast milk. Analytical and Bioanalytical Chemistry, 412, 1027–1035. Retrieved from https://doi.org/10.1007/s00216-019-02342-8
. (2020). Prediagnostic breast milk DNA methylation alterations in women who develop breast cancer. Human Molecular Genetics, 29, 662–673. Retrieved from https://doi.org/10.1093/hmg/ddz301
. (2020). Inter-Individual Variation in Response to Estrogen in Human Breast Explants. J Mammary Gland Biol Neoplasia, 25(1), 51-68. presented at the 2020 03. doi:10.1007/s10911-020-09446-3
. (2018). DNA methylation in breast cancers: Differences based on estrogen receptor status and recurrence. Journal of Cellular Biochemistry. presented at the sep. Retrieved from https://doi.org/10.1002/jcb.27431
. (2018). TROP2 methylation and expression in tamoxifen-resistant breast cancer. Cancer Cell International, 18. presented at the jul. Retrieved from https://doi.org/10.1186/s12935-018-0589-9
. (2018). Dietary Intervention to Increase Fruit and Vegetable Consumption in Breastfeeding Women: A Pilot Randomized Trial Measuring Inflammatory Markers in Breast Milk. Journal of the Academy of Nutrition and Dietetics. presented at the sep. Retrieved from https://doi.org/10.1016/j.jand.2018.06.015
. (2018). Comparative two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) of human milk to identify dysregulated proteins in breast cancer, 39, 1723–1734. presented at the jun. Retrieved from https://doi.org/10.1002/elps.201800025
. (2018). Proteomics analysis of human breast milk to assess breast cancer risk. ELECTROPHORESIS, 39, 653–665. presented at the feb. Retrieved from https://doi.org/10.1002/elps.201700123
. (2018). Pro-inflammatory cytokines and growth factors in human milk: an exploratory analysis of racial differences to inform breast cancer etiology. Breast Cancer Research and Treatment. presented at the aug. Retrieved from https://doi.org/10.1007/s10549-018-4907-7
. (2017). Tools to minimize interlaboratory variability in vitellogenin gene expression monitoring programs. Environmental Toxicology and Chemistry, 36, 3102–3107. presented at the aug. Retrieved from https://doi.org/10.1002/etc.3885
. (2017). White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Breast Cancer Research, 19. presented at the aug. Retrieved from https://doi.org/10.1186/s13058-017-0886-6
. (2017). Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors. Journal of Cancer Epidemiology, 2017, 1–25. Retrieved from https://doi.org/10.1155/2017/2705860
. (2016). ELF5 and DOK7 regulation in anti-estrogen treated cells and tumors. Cancer Cell Int, 16, 8. presented at the 2016.
. (2016). Potential of breastmilk analysis to inform early events in breast carcinogenesis: rationale and considerations. Breast Cancer Res Treat, 157(1), 13-22. presented at the 2016 May.
. (2016). Depression, Antidepressant Use, and Postmenopausal Breast Cancer Risk. Cancer Epidemiol Biomarkers Prev, 25(1), 158-64. presented at the 2016 Jan.
. (2015). Urinary melatonin concentration and the risk of breast cancer in Nurses' Health Study II. Am J Epidemiol, 181(3), 155-62. presented at the 2015 Feb 1.
. (2015). Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Epigenetics, 10(6), 545-61. presented at the 2015.
. (2015). Association of TGF-β2 levels in breast milk with severity of breast biopsy diagnosis.. Cancer Causes Control, 26(3), 345-54. presented at the 2015 Mar.
. (2014). Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics. Adv Exp Med Biol, 806, 399-408. presented at the 2014.
. (2014). SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer. J Cell Physiol, 229(9), 1160-9. presented at the 2014 Sep.
. (2014). Determination of free Bisphenol A (BPA) concentrations in breast milk of U.S. women using a sensitive LC/MS/MS method. Chemosphere, 104, 237-43. presented at the 2014 Jun.
. (2014). High-density array analysis of DNA methylation in tamoxifen-resistant breast cancer cell lines. Epigenetics, 9(2). presented at the 2014 Feb.
. (2014). Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development. BMC Microbiol, 14(1), 277. presented at the 2014 Dec 4.
. (2014). Promoter Methylation in Epithelial-Enriched and Epithelial-Depleted Cell Populations Isolated from Breast Milk. J Hum Lact. presented at the 2014 Aug 27.
. (2014). Human Mammary Tumor Virus (HMTV) sequences in human milk. Infect Agent Cancer, 9, 20. presented at the 2014.
. (2014). DNA methylation in paired breast epithelial and white blood cells from women undergoing reduction mammoplasty. Anticancer Res, 34(6), 2985-90. presented at the 2014 Jun.
. (2013). The ras homolog gene family, member A (RhoA) pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line. J Cell Biochem. presented at the 2013 Jun.
. (2013). Postpartum Remodeling, Lactation, and Breast Cancer Risk: Summary of a National Cancer Institute-Sponsored Workshop. J Natl Cancer Inst. presented at the 2013 Nov 13.
. (2012). Differential expression of cancer-related proteins in paired breast milk samples from women with breast cancer. Journal of human lactation : official journal of International Lactation Consultant Association, 28(4), 543-6. presented at the 2012 Nov.
. (2012). Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy. BMC cancer, 12, 100. presented at the 2012.
. (2012). Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers. Cancer cell international, 12(1), 17. presented at the 2012.
. (2012). Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls. Epigenetics : official journal of the DNA Methylation Society, 7(11), 1258-67. presented at the 2012 Nov 1.
. (2011). Increased promoter methylation in exfoliated breast epithelial cells in women with a previous breast biopsy. Epigenetics : official journal of the DNA Methylation Society, 6(12), 1425-35. presented at the 2011 Dec 1.
. (2010). The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles. Small (Weinheim an der Bergstrasse, Germany), 6(20), 2246-9. presented at the 2010 Oct 18.
. (2010). Surface properties dictate uptake, distribution, excretion, and toxicity of nanoparticles in fish. Small (Weinheim an der Bergstrasse, Germany), 6(20), 2261-5. presented at the 2010 Oct 18.
. (2010). Quantitative analysis of promoter methylation in exfoliated epithelial cells isolated from breast milk of healthy women. Epigenetics : official journal of the DNA Methylation Society, 5(7), 645-55. presented at the 2010 Oct 1.
. (2010). Quantitative analysis of promoter methylation in exfoliated epithelial cells isolated from breast milk of healthy women. Epigenetics : official journal of the DNA Methylation Society, 5(7), 645-55. presented at the 2010 Oct 1.
. (2010). Effects of exposure water volume, depuration time, and feeding status on vitellogenin mRNA induction in male medaka (Oryzias latipes) exposed to 17 β-estradiol.. Ecotoxicology and environmental safety, 73(8), 1835-41. presented at the 2010 Nov.
. (2008). Perfluorinated compounds in human milk from Massachusetts, U.S.A. Environmental science & technology, 42(8), 3096-101. presented at the 2008 Apr 15.
. (2007). Polybrominated diphenyl ethers and organochlorine pesticides in human breast milk from Massachusetts, USA. Journal of environmental monitoring : JEM, 9(11), 1205-12. presented at the 2007 Nov.
. (2007). Synthetic musk fragrances in human milk from the United States. Environmental science & technology, 41(11), 3815-20. presented at the 2007 Jun 1.
. (2006). Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer. Molecular cancer research : MCR, 4(12), 905-13. presented at the 2006 Dec.
. (2006). Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer. Molecular cancer research : MCR, 4(12), 905-13. presented at the 2006 Dec.
. (2004). Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures. Anticancer research, 24(1), 139-44. presented at the 2004 Jan-Feb.
. (2004). Differential action of polycyclic aromatic hydrocarbons on endogenous estrogen-responsive genes and on a transfected estrogen-responsive reporter in MCF-7 cells. Toxicology and applied pharmacology, 196(1), 58-67. presented at the 2004 Apr 1.
Veterinary and Animal Sciences