Previous Seminars

Tissue specific hydrogels and tumor dormancy

Shelly Peyton, PhD
UMass Amherst, Chemical Engineering

Wed, 5/1/2024 - 4:00pm
221 Integrated Sciences Building

Host: Lisa Minter, VASCI Department Head

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Evaluating immune responses to radiation therapy and immunomodulation in translational animal models of head and neck cancer

Keara Boss, DVM, PhD
Colorado State University

Wed, 4/24/2024 - 4:00pm
221 Integrated Sciences Building

Host: Joseph Jerry, PhD

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Heritable variation in gene expression is the key contributor to phenotypic change and genetic diversity in Holstein cattle.

Tom Lawlor, PhD
Holstein Association USA

Wed, 4/17/2024 - 4:00pm
221 Integrated Sciences Building

Host: Richard Goldsby, PHD

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Necroptosis, inflammation, and tumorigenesis

Zheng Gang Liu, PhD
National Cancer Institute, NIH

Wed, 4/10/2024 - 4:00pm
221 Integrated Sciences Building

Host: Elena Pobezinskaya, PhD

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Trafficking of proteins: relevance to germ cell differentiation and fertility

Eugenia Teves, PhD
Virginia Commonwealth, Richmond

Wed, 4/3/2024 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, PhD

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A new insight into regulatory T cell development in the thymus

Xuguang Tai, PhD
National Cancer Institute, NIH

Wed, 3/27/2024 - 4:00pm
221 Integrated Sciences Building

Host: Leonid Pobezinsky, PhD

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Mycobacterial cell envelope: challenges and opportunities

Sloan Siegrist, PhD
UMass Amherst, Microbiology

Wed, 3/13/2024 - 4:00pm
221 Integrated Sciences Building

Host: Alissa C. Rothchild, PhD

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Deconstructing human skeletal muscle development in vitro

Olivier Pourquier, PhD
Harvard University

Wed, 3/6/2024 - 4:00pm
221 Integrated Sciences Building

Host: Dom Alfandari, PhD

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Cellular Mechanisms Driving Taupathy Disease Progression

Jenny Rauch, PhD
UMass Amherst, Biochemistry and Molecular Bio

Wed, 2/28/2024 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, PhD

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Functional studies of genetic variation using precision genome editing

Francisco J. Sánchez-Rivera, PhD
Department of Biology & Koch Institute at MIT

Wed, 2/21/2024 - 4:00pm
221 Integrated Sciences Building

Host: Joseph Jerry, PhD

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Sperm's Signal: The Role of Factors in Generating the Ca2+ Oscillations during Mouse Egg Activation

Neha Gupta, PhD candidate
UMass Amherst VASCI

Wed, 2/14/2024 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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LILRB3 and BTN2A2 Receptors: Novel Immune Checkpoint Inhibitors for Reducing Inflammation

Deeksha Mohan, PhD candidate
UMass Amherst VASCI

Wed, 2/14/2024 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment

Nidhi Jadon, PhD candidate
UMass Amherst VASCI

Wed, 2/14/2024 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Graduate Student Gathering

Lisa Minter
UMass Amherst VASCI

Wed, 2/7/2024 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Graduate Student Presentations

A. Chander & A. Banas
UMass Amherst VASCI

Wed, 12/6/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Investigating the role of Bre1 complex in early mouse embryonic development

Ashmita Chander, PhD Candidate, ABBS program
UMass Amherst

Wed, 12/6/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Does chronic inflammation alter DNA methylation in breast cells?

Ashley Banas, PhD candidate, ABBS program
UMass Amherst

Wed, 12/6/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Graduate Student Presentations

J. Welton, F. Carpentiero
UMass Amherst VASCI

Wed, 11/29/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Investigating the Sexually Dimorphic Embryonic Lethality of CMTR1 Knockouts

Janelle Welton, Graduate Student, MCB Program
UMass Amherst

Wed, 11/29/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Examining the role of plasma membrane channels that mediate divalent cation influx in oocytes and granulosa cells

Francesca Carpentiero, Graduate Student, ABBS program
UMass Amherst

Wed, 11/29/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Graduate Student Presentations

T. Guertin, X. Liang
UMass Amherst VASCI

Wed, 11/15/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Exploring the molecular mechanism of let-7-mediated CD8 T cell differentiation

Xueting (Darren) Liang, PhD candidate, ABBS program
UMass Amherst

Wed, 11/15/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Analyzing the the role of N-linked glycosylation during placental morphogenesis

Taylor Guertin, PhD Candidate, MCB Program
UMass Amherst

Wed, 11/15/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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The role of extracellular matrix quality in tumor-induced skeletal fragility

Stacyann Bailey, PhD
UMass Amherst

Wed, 11/8/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Activation of signaling pathways in the sperm flagellum regulates GSK3 alpha in the sperm head

Gayatri Mohanty, PhD
UMass Amherst

Wed, 11/1/2023 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, PhD

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Using the startle reflex as a readout of pre-attentive processing

Karine Fenelon, PhD
UMass Amherst

Wed, 10/25/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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3D genome reorganization underlies cytotoxic T cell differentiation

Hai-Hui Xue, MD & PhD
Hackensack Medical Center

Wed, 10/18/2023 - 4:00pm
221 Integrated Sciences Building

Host: Darren Liang, ABBS PhD candidate

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Dendritic cell Recognition of Bacterial Biofilms fuels Autoimmunity

Stefania Galluci, MD
UMass Chan Medical

Wed, 10/11/2023 - 4:00pm
221 Integrated Sciences Building

Host: Lisa Minter, VASCI Department Head

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Inducing Graft-versus-Leukemia Responses in Humanized Mouse Models?

Olivia George, Undergraduate Student Research Assistant
UMass Amherst

Wed, 10/4/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Investigating the consequences of TRPM7 deletion during cleavage stages of mouse embryos and its expression in bovine oocyte, sperm, and cumulus cells

Ridha Alam, Undergraduate Student Research Assistant
UMass Amherst

Wed, 10/4/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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DNA Methylation as a Biomarker for Individual Breast Cancer Risk

Molly Hoffenberg, Undergraduate Student Research Assistant
UMass Amherst

Wed, 10/4/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Macrophage lipid metabolism during Mycobacterium tuberculosis infection

Aiden McKeeby, Undergraduate Student Research Assistant
UMass Amherst

Wed, 10/4/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Undergraduate Research Presentations

Undergraduate Students
UMass Amherst VASCI

Wed, 10/4/2023 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Graduate Program Director

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Obesity, Immunotherapy, and Cancer: Paradox or Parsimonious?

Rachel Perry. PhD: Perry Lab
Yale University

Wed, 9/27/2023 - 4:00pm
221 Integrated Sciences Building

Host: Maeve Smith, ABBS Graduate Student

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GLI proteins: From cancer cells to the TME to the Immune system

Sherine Elsawa, PhD
University of New Hampshire

Wed, 9/20/2023 - 4:00pm
221 Integrated Sciences Building

Host: Ashley Banas, ABBS PhD candidate

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Welcome Reception for Graduate Students

Wed, 9/13/2023 - 4:00pm
ISB 4th floor atrium

ABBS Graduate Program

Host: Lisa Minter, VASCI Department Head

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Large Scale Analysis of Early Lethal Phenotypes in the Mouse

Jesse Mager, PhD
UMass Amherst

Wed, 5/10/2023 - 4:00pm
221 Integrated Sciences Building

Host: Alissa Rothchild

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Gut microbes and their genes predict neurocognitive development in early life

Kevin Bonham
Wellesley College

Wed, 5/3/2023 - 4:00pm
221 Integrated Sciences Building

Host: Alissa Rothchild

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The enigmatic role of CD8 T cells in immunity to tuberculosis

Samuel Behar
UMass Medical School

Wed, 4/26/2023 - 4:00pm
221 Integrated Sciences Building

Host: Alissa Rothchild

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TBA

Lixia Yue
UConn Health Center

Wed, 4/19/2023 - 4:00pm
221 Integrated Sciences Building

Host: Rafael Fissore

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Taming T cell responses with B. subtilis

Barbara Osborne
UMass Amherst

Wed, 4/12/2023 - 4:00pm
221 Integrated Sciences Building

Host: Alissa Rothchild

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Sperm Information Games: Framing Sperm Physiology Through the Lens of the Reproductive Microenvironment

Cameron Schmidt
East Carolina University, NC

Wed, 4/5/2023 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti

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Deciding between a desirable mate and an unwanted one: the long and winding road to fertilization in flowering plants

Alice Cheung
UMass Amherst

Wed, 3/29/2023 - 4:00pm
221 Integrated Sciences Building

Host: Dom Alfandari

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Mechanisms of breast cancer metastasis and drug resistance

Madeleine Oudin
Tufts University

Wed, 3/22/2023 - 4:00pm
221 Integrated Sciences Building

Host: Dom Alfandari

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Aneuploidy cell fate in human early development.

Min Yang
Rockefeller University

Wed, 3/8/2023 - 3:45pm
221 Integrated Sciences Building

Host: Doris He

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Graduate Student Research Presentations

Emily Lopes, Linh Pham
UMass Amherst

Wed, 3/1/2023 - 4:00pm
221 Integrated Sciences Building

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Probing the Signaling Toolkit of Fertilization: It is more than just Calcium and PLCzeta.

Rafael A. Fissore, PhD.
UMass VASCI

Wed, 12/7/2022 - 4:00pm
221 Integrated Sciences Building

Host: Leonid A. Pobezinsky, PhD.

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Student Presentations

Ana Clara Viana & Neha Gupta
UMass VASCI

Wed, 11/30/2022 - 4:00pm
221 Integrated Sciences Building

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Essential roles for zinc and potassium ions in ovarian function

Francisco J. Diaz, PhD
Penn State

Wed, 11/16/2022 - 4:00pm
221 Integrated Sciences Building

Host: Rafael A. Fissore, PhD.

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The Molecular Basis for Lysosomal Diseases

Scott Garman, PhD
UMass, Biochemistry & Molecular Biology

Wed, 11/9/2022 - 4:00pm
221 Integrated Sciences Building

Host: Lisa Minter

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Regulators of Innate Immune Memory in Macrophages

Tanapat Palaga, Ph.D.: Palaga Lab
Chulalongkorn University

Tue, 11/8/2022 - 4:00pm
221 Integrated Sciences Building

Host: Barbara Osborne

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Developing tools and methods to study Craniofacial development

Dom Alfandari, PhD
UMass VASCI

Wed, 11/2/2022 - 4:00pm
221 Integrated Sciences Building

Host: Leonid Pobezinsky

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Role of endogenous retroviruses in the control of tissue threshold of activation and responses to the microbiota

Alex Wells, PhD
National Institute for Health

Wed, 10/26/2022 - 4:00pm
221 Integrated Sciences Building

Host: Leonid A. Pobezinsky, PhD.

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Student Presentations

Nidhi Jadon & Hiroki Akizawa
UMass VASCI

Wed, 10/19/2022 - 4:00pm
221 Integrated Sciences Building

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BNT221, an autologous neoantigen-specific T cell product for adoptive cell therapy of metastatic ovarian cancer

Tina Arieta, PhD
BioNTech

Wed, 10/12/2022 - 4:00pm
221 Integrated Sciences Building

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The Epithelial-Mesenchymal Transition drives refractory responses of breast carcinomas to immune checkpoint blockade therapies

Anushka Dongre, PhD: Dongre Lab at Cornell College of Veterinary Medicine
Cornell College of Veterinary Medicine

Wed, 10/5/2022 - 4:00pm
221 Integrated Sciences Building

Host: Barbara Osborne

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Engineering nanomaterials-based systemic immuno-modulatory technologies to reprogram tumor microenvironment immunity

Prabhani U. Atukorale, Ph.D.
UMass - Biomedical Engineering

Wed, 4/27/2022 - 4:00pm
221 Integrated Sciences Building

Host: Barbara A. Osborne, PhD

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Novel axes of translation regulation in mammalian male germ cells

Elizabeth Snyder, PhD
Rutgers University

Wed, 4/13/2022 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, PhD

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On the case of the interfering interferon: Understanding how IFN signaling impairs the adaptive immune response to malaria infection

Nana Minkah, PhD
Seattle Children's Research Institute

Wed, 4/6/2022 - 4:00pm
221 Integrated Sciences Building

Host: Alissa Rothchild, PhD

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The breast milk immune response to SARS-CoV-2: Infection vs vaccination

V. Narayanaswamy, PhD candidate: Arcaro Lab
UMass - VASCI

Wed, 3/30/2022 - 4:00pm
221 Integrated Sciences Building

Host: Joseph Jerry, PhD

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Berberine alleviates LPS-induced apoptosis, oxidation, and skewed lineages during mouse preimplantation development

Sue Miao, PhD candidate: Cui Lab
UMass VASCI

Wed, 3/30/2022 - 4:00pm
221 Integrated Sciences Building

Host:  Joseph Jerry, PhD

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Estrogen therapy for ER+ breast cancer: mechanistic insights and opportunities for enhanced efficacy

Todd Miller
Dartmouth Hitchcock Medical Center

Wed, 3/23/2022 - 4:00pm
221 Integrated Sciences Building

Host: Joseph Jerry

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Generation of mouse conditional alleles by using different methods: CRISPR/Cas9 vs. ESCs

Wei Cui, PhD
UMass - VASCI

Wed, 12/8/2021 - 4:00pm
221 Integrated Sciences Building

Host: Jesse Mager, PhD

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How malaria impacts T cell immunity to EBV co-infections and increases the risk of endemic Burkitt lymphoma for African children

Ann Moormann, PhD, MPH
Mass Medical School

Wed, 12/1/2021 - 4:00pm
221 Integrated Sciences Building

Host: Barbara A. Osborne, PhD

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Development of a portable lung function test for horses

Professor Melissa R. Mazan, DVM, ACVIM
Tufts Cummings School of Veterinary Medicine

Wed, 11/17/2021 - 4:00pm
221 Integrated Sciences Building

Host: Carlos M. Gradil, DVM, MS, PhD, DACT

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Let-7 miRNA defines productive vs non-productive immune response

Leonid Pobezinsky, PhD
UMass - VASCI

Wed, 11/10/2021 - 4:00pm
221 Integrated Sciences Building

Host: D. Joseph Jerry, PhD

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Targeting Urologic Cancers

Darryl Martin, PhD
Yale University School of Medicine

Wed, 10/27/2021 - 4:00pm
221 Integrated Sciences Building

Host: Pamelia Lim, PhD candidate

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Investigating B cell / T cell interactions to identify therapeutic opportunities for cancer patients

Daniel Hollern, PhD
Salk Institute

Wed, 10/20/2021 - 4:00pm
221 Integrated Sciences Building

Host: Joseph Jerry, PhD

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Paternal environmental effects in mammals: programming of health and disease in future generations

Oliver Rando, PhD
UMass Medical

Wed, 10/13/2021 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, PhD

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V-ATPase positive cells are immune-modulators in the urogenital tract

Maria Agustina Battistone, PhD
Mass General Hospital, Harvard University

Wed, 10/6/2021 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, PhD

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Preponderant tolerogenic innate T cell immunity at tadpole stage in the amphibian Xenopus

Jacques Robert, PhD
University of Rochester Medical Center

Wed, 9/29/2021 - 4:00pm
221 Integrated Sciences Building

Host: Dom Alfandari, PhD

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TB or Not TB? Genetic Reprogramming of Mycobacterium tuberculosis for Vaccine Development

Amanda Martinot, DVM, MPH, PhD, DACVP
Tufts Cummings School of Veterinary Medicine

Wed, 9/22/2021 - 4:00pm
221 Integrated Sciences Building

Host: Alissa Rothchild, PhD

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Focusing on the Gap in Chemotherapy Response

Sharon Cantor, PhD: Cantor Lab at UMass Medical School
UMass Medical School

Wed, 4/28/2021 - 4:00pm
via Zoom link

Host: Joe Jerry, PhD

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Analyzing the effect of early-life antibiotic treatment on peripheral blood immune cells in premature infants

Dr. Gabriela Gonzalez-Perez
National Institute of Perinatology

Wed, 4/21/2021 - 4:00pm
via Zoom

Host: Lisa Minter, PhD

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Being in the right place at the right time: modulation of PKA positioning during sperm capacitation

Cintia Stival, PhD
Institute of Molecular & Cellular Biology

Wed, 4/7/2021 - 4:00pm
via Zoom link
Cell Signal Transduction Networks, Institute of Molecular and Cellular Biology of Rosario, Argentina

Host: Ana Maria Salicioni, PhD

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Understanding and Targeting the R-Loop-Mediated DNA Damage Response in Cancer

Li Lan MD. PhD.
Harvard University

Wed, 3/31/2021 - 4:00pm
via Zoom

Host: Joe Jerry, PhD

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Cancer Research in Veterinary Medicine - A VASCI Alum’s role in Oncology Clinical Trials

Gretchen McLinden, DVM
Cummings School of Veterinary Medicine
Cummings Veterinary Clinical Trials

Wed, 3/24/2021 - 4:00pm
via Zoom link

Notes: Gretchen McLinden, DVM is a graduate of VASCI '15 and Cummings School of Veterinary Medicine at Tufts University, class of 2019. After her Cummings graduation, she went on to complete a rotating internship at BluePearl Veterinary Partners in New York City. With a strong interest in medical oncology, Dr. McLinden is excited to return to Cummings School to complete a specialty internship with the Clinical Trials Office, focusing on caring for the patients enrolled in the oncology clinical trials.

Host: Helene Cousin, PhD

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Host-pathogen genetic interactions underlie tuberculosis disease states

Clare Smith, PhD: Smith Lab at Duke University
Duke University

Wed, 3/17/2021 - 4:00pm
via Zoom link

Host: Alissa Rothchild, PhD

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Inducible HER2 expression in mice and the signaling in cancers

Bill Muller, PhD
McGill University

Wed, 3/10/2021 - 4:00pm
via Zoom link

Host: Joe Jerry, PhD

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Assisted Reproductive Technologies for Wildlife Conservation in the Brazilian Caatinga Biome

Alexandre Rodrigues Silva, PhD, DVM
Federal University of Semiarid Region - UFERS

Wed, 3/3/2021 - 4:00am
via Zoom link

Host: Rafael Fissore, PhD, DVM

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It Will All Get Better with Time - Controlling the Timing of Therapeutic Delivery to Enhance Regenerative Medicine Strategies

Cathal Kearney, PhD
UMass Amherst

Wed, 2/17/2021 - 4:00pm
via Zoom link

Host: Barbara A. Osborne, PhD

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Finding New Mechanisms for Old Cancer Drugs

Michael Heeman, PhD: Hemann Lab at MIT
MIT & the Koch Institute

Wed, 2/10/2021 - 4:00pm
via Zoom link

Host: Richard Goldsby, PhD

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An interview with Richard Goldsby, Distinguished Fellow of the American Association of Immunologists 2021

Richard Goldsby, PhD
Amherst College & UMass Amherst

Wed, 2/3/2021 - 4:00pm
via Zoom

More about the awardees of 2021.
Interview with Dr. Goldsby.

Host: Cynthia Baldwin, PhD

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Rods and Cones: How they stay fresh and functional for a lifetime

Abigail Jensen, PhD
UMass Amherst

Wed, 11/18/2020 - 4:00pm
via Zoom

Host: Kathleen Arcaro, PhD

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Imaging how cells choose their fate, shape and position to form the early mammalian embryo

Nicolas Platcha, PhD
UPenn

Wed, 11/11/2020 - 4:00pm
via Zoom

Host: Maria Gracia Gervasi, PhD

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From Egg to Adult - Functions and Regulation of TRPM7 and TRPM6 Channels

Loren Runnels, PhD
Rutgers University

Wed, 11/4/2020 - 4:00pm
via Zoom

Host: Rafael Fissore, PhD

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IL-27 signaling in anti-HIV T cell mediated immunity

Marta Catalfamo, PhD
Georgetown University

Wed, 10/28/2020 - 4:00pm
via Zoom

Host: Leonid Pobezinsky, PhD

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Time to Reassess the Use of GRE Scores in the STEM Doctoral Program Admissions Process

Sandy Petersen, PhD
UMass Amherst

Wed, 10/21/2020 - 4:00pm
via Zoom

Host: Joe Jerry, PhD

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CANCELLED - FSTL3 Neutralizing Antibody As A Potential Diabetes Therapy

Alan Schneyer, PhD
Fairbanks Pharmaceutical

Wed, 10/14/2020 - 4:00pm
via Zoom

Host: Joe Jerry, PhD

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Long noncoding RNA's interact with bromodomain proteins to regulate endoderm differentiation

Alan Mullen, PhD
Harvard University

Wed, 10/7/2020 - 4:00pm
via Zoom

Host: Kim Tremblay, PhD

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SCENITH, a Simple method for Complex immunometabolic profiling: lessons from tumors

Rafael Arguello, PhD
Aix-Marseille University

Wed, 9/30/2020 - 4:00pm
via Zoom

Host: Maria Gracia Gervasi, PhD

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A Bayesian Nonparametric Model for Inferring Subclonal Populations from Structured DNA Sequencing Data

Patrick Flaherty, PhD
UMass Amherst

Wed, 9/23/2020 - 4:00pm
via Zoom

Host: Joe Jerry, PhD

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DNA double strand breaks: Causes and Consequences

Jacqueline Barlow, PhD
UC Davis

Wed, 9/16/2020 - 4:00pm
via Zoom

Host: Joe Jerry, PhD

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CANCELLED - to be rescheduled in Fall 2020 semester - Medical Zoology: studies of vector borne diseases including Lyme and Malaria

Stephen Rich, PhD
UMass Amherst

Wed, 4/29/2020 - 4:00pm
221 Integrated Sciences Building

Host: Alexandria Gillespie

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CANCELLED - to be rescheduled in Fall 2020 semester - Long noncoding RNAs interact with bromodomain proteins to regulate endoderm differentiation.

Alan Mullen, MD, PhD: Mullen Lab
Harvard Medical School

Wed, 4/15/2020 - 4:00pm
221 Integrated Sciences Building

Host: Kim Tremblay, PhD

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CANCELLED - to be rescheduled in Fall 2020 semester - Food and environmental compounds in the development of obesity

Yeonhwa Park, PhD
UMass Amherst

Wed, 4/8/2020 - 4:00pm
221 Integrated Sciences Building

Host: John Clark, PhD

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CANCELLED - to be rescheduled in Fall 2020 semester - Decolonizing Botany: From the Herbarium to the Planetarium

Banu Subramaniam, PhD
UMass Amherst

Wed, 4/1/2020 - 4:00pm
221 Integrated Sciences Building

Host: Kim Tremblay, PhD

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CANCELLED - to be rescheduled in Fall 2020 semester - Control of cell fate and morphology by Phosphatase PP2A in the developing eye epithelium of Drosophila

Francesca Pignoni, PhD
Upstate Medical University, New York

Wed, 3/25/2020 - 4:00pm
221 Integrated Sciences Building

Host: Dom Alfandari

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Energy Based Cancer Therapy

Govind Srimathveeravalli, PhD
UMass Amherst

Wed, 3/11/2020 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, PhD

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Antibody-Dependent Phagocytosis of HIV by Leukocytes Isolated from Human Breast Milk

Rebecca Powell, PhD
Icahn School of Medicine at Mt. Sinai

Wed, 3/4/2020 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, PhD

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From Basic Research to the Business of Drug Development – One Path to a Career in the Life Sciences

Grant Morgan, PhD, PMP
CamAlex Castle Consulting

Wed, 2/26/2020 - 4:00pm
221 Integrated Sciences Building

Grant Morgan, Ph.D., PMP is an independent consultant with CamAlex Castle Consulting currently consulting for LifeArc, a British life science medical research charity. Dr. Morgan completed his PhD with Sam Black, PhD and his post-doc with Barbara Osborne, PhD.

Host: Cynthia Baldwin, PhD & Barbara Osborne, PhD

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Biological Safety Training

Environmental Health & Safety
UMass Amherst

Wed, 2/19/2020 - 4:00pm
221 Integrated Sciences Building

Host: VASCI

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How to reduce the risks of colonic inflammation and colon cancer? Identification of novel therapeutic targets and risk factors

Guodong Zhang, PhD
UMass Amherst

Wed, 2/12/2020 - 4:00pm
221 Integrated Sciences Building

Host: Lisa Minter, PhD

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Nutritional regulation of brown and beige fat activation

Soonkyu Chung, PhD
UMass Amherst

Wed, 2/5/2020 - 4:00pm
221 Integrated Sciences Building

Host: Joe Jerry, PhD

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Keeping Sperm Out of Fertilized Eggs

Anne Carlson, PhD: Carlson Lab
University of Pittsburgh

Wed, 1/29/2020 - 4:00pm
221 Integrated Sciences Building

Host: Rafael Fissore, PhD

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Epithelial-to-Mesenchymal Transition regulates Immunosuppression in Breast Carcinomas

Anushka Dongre, PhD
Whitehead Institute at MIT
Anushka Dongre, Weinberg Lab at Whitehead Institute

Wed, 12/11/2019 - 4:00pm
221 Integrated Sciences Building

Host: Barbara A. Osborne

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Laboratory Safety and Hazardous Waste Management

Environmental Health & Safety
UMass Amherst

Wed, 12/4/2019 - 4:00pm
221 Integrated Sciences Building

Host: Department of Veterinary and Animal Sciences

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The evolution and functional specificity of cytoskeletal networks

LILLIAN FRITZ-LAYLIN, PhD
UMass Amherst

Wed, 11/20/2019 - 4:00pm
221 Integrated Sciences Building

Host: Barbara A. Osborne

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Mesenchymal stromal cells and Tregs in the physiopathology of adipose tissue

RAUL GERMAN SPALLANZANI, PhD
Harvard Medical School

Wed, 11/13/2019 - 4:00pm
221 Integrated Sciences Building

Host: Ana Maria Salicioni

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Taming T cells through a Tyrosine Phosphatase

ULRIKE LORENZ, PhD
University of Virginia

Wed, 11/6/2019 - 4:00pm
221 Integrated Sciences Building

Host: Barbara A. Osborne

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mTORC2 governs adipocyte differentiation and lipid metabolism via AKT-dependent ACLY phosphorylation

CAMILA MARTINEZ CALEJMAN, PhD
UMass Medical School

Wed, 10/30/2019 - 4:00pm
221 Integrated Sciences Building

Host: Maria Gracia Gervasi. PhD

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Risk factors for early natural menopause

BRIAN WHITCOMB, PhD
UMass Amherst

Wed, 10/23/2019 - 4:00pm
221 Integrated Sciences Building

Host: Rafael Fissore, PhD

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Mechanisms of transgenerational inheritance of obesity epiphenotypes

VICTOR CORCES, PhD
Emory University

Wed, 10/16/2019 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, PhD

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Using bacterial delivery to cross the cell membrane

Nele van Dessel, PhD
UMass

Wed, 10/9/2019 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, PhD

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Human Head Louse Infestations: Cooties and what to do!

JOHN M. CLARK, PhD
UMass Amherst

Wed, 10/2/2019 - 4:00pm
221 Integrated Sciences Building

Host: Cynthia Baldwin, PhD

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Cell polarity oscillations in mitotic epithelia

KATERINA RAGKOUSI, PhD
Amherst College

Wed, 9/25/2019 - 4:00pm
221 Integrated Sciences Building

Host: Jesse Mager, PhD

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A Molecular Switch for ERbeta Antitumor Activity in Tumor and Immune Cells

Rong Li, PhD
The George Washington University

Wed, 9/18/2019 - 4:00pm
221 Integrated Sciences Building

Host: Joe Jerry, PhD

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TBA

Darya Tourzani, PhD student
UMass Amherst

Wed, 4/24/2019 - 4:00pm
221 Integrated Sciences Building

Host: Animal Biotechnology & Biomedical Sciences Graduate Program

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Reporter Probes for real-time imaging of inflammasome activation

Dipika Nandi, PhD student
UMass Amherst

Wed, 4/24/2019 - 4:00pm
221 Integrated Sciences Building

Host: Animal Biotechnology & Biomedical Sciences Graduate Program

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Transcriptional regulation of early lymphocyte development

Toshimi Yoshida, PhD
Massachusetts General Hospital

Wed, 4/10/2019 - 4:00pm
221 Integrated Sciences Building

Host: Dom Alfandari, PhD

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Going against the tide: a novel RNA element protects against viral-induced RNA decay

Mandy Muller, PhD
UMass Amherst

Wed, 4/3/2019 - 4:00pm
221 Integrated Sciences Building

Host: Cynthia Baldwin, PhD

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Preconception Opioid Exposure has Bidirectional Effects on Morphine and Cocaine Reward in Offspring

Fair Vassoler, PhD
Cummings School of Veterinary Medicine

Wed, 3/27/2019 - 4:00pm
221 Integrated Sciences Building

Host: Jesse Mager, PhD

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Identifying Core genes involved in Successful Vertebrate CNS axon regeneration

Ben Szaros, PhD
University at Albany SUNY

Wed, 3/20/2019 - 4:00pm
221 Integrated Sciences Building

Host: Dom Alfandari, PhD

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Deciphering thymus development with functional genomics and pluripotent stem cells

René Maehr, PhD: Maehr Lab
UMass Medical School

Wed, 3/6/2019 - 4:00pm
221 Integrated Sciences Building

Host: Kimberly D. Tremblay, PhD

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Building Tissue-Specific Centrosomes

Nasser M. Rusan, Ph.D.: Rusan Lab
National Institutes of Health

Wed, 2/27/2019 - 4:00pm
221 Integrated Sciences Building

Host: Rafael A. Fissore, PhD

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Quantifying Intercellular Forces by Membrane DNA Probes

Mingxu You, PhD
UMass Amherst

Wed, 2/13/2019 - 4:00pm
221 Integrated Sciences Building

Host: Barbara Osborne, PhD

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The Road Not Taken; Bacteriocins: An alternative to conventional antibiotics

Peg Riley, PhD
UMass Amherst

Wed, 2/6/2019 - 4:00pm
221 Integrated Sciences Building

Host: Barbara Osborne, PhD

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Complex Coacervation as a Novel Method for Thermal Stabilization of Biomacromolecules

Whitney Blocher McTigue,PhD student
UMass Amherst

Wed, 1/30/2019 - 4:00pm
221 Integrated Sciences Building

Host: Animal Biotechnology & Biomedical Sciences Graduate Program

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Targeting CD4+ T-ALL Tumors with Anti-CD4 Conjugated, Chemotherapeutic Drug Loaded Nanogels

Mine Canakci, PhD student
UMass Amherst

Wed, 1/30/2019 - 4:00pm
221 Integrated Sciences Building

Animal Biotechnology & Biomedical Sciences Graduate Program

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Liver Regeneration: Remembering Liver Developmental Cues

Valerie Gouon-Evans, PharmD, PhD
Boston University

Wed, 12/5/2018 - 4:00pm
221 Integrated Sciences Building

Host: Kimberly D. Tremblay, PhD

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The developmental layers of the CD8+ T cell response to infection

Brian D. Rudd, PhD
Cornell University

Wed, 11/14/2018 - 4:00am
221 Integrated Sciences Building

Host: Leonid Pobezinsky, PhD

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Innate host responses to parasitic infections in the gastrointestinal tract

Felix Yarovinsky, MD
University of Rochester Medical Center

Wed, 11/7/2018 - 4:00pm
221 Integrated Sciences Building

Host: Leonid Pobezinsky, PhD

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Understanding the stem cell properties of cancer cells

Michele Markstein, PhD
UMass Amherst

Wed, 10/31/2018 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti

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Segregating chromosomes in the early mammalian embryo

Greg Fitzharris, PhD
Université de Montréal

Wed, 10/24/2018 - 4:00pm
221 Integrated Sciences Building

Host: Rafael A. Fissore, PhD

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Growth-independent remodeling of the mycobacterial cell envelope

Sloan Siegrist, PhD
UMass Amherst

Wed, 10/17/2018 - 4:00pm
221 Integrated Sciences Building

Host: Cynthia Baldwin, PhD

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Epigenetics in reproduction, silencing of transposable elements

P. Jeremy Wang, MD, PhD
UPenn

Wed, 10/10/2018 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti

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Dogs as Support & Motivation for Physical Activity & Health

Katie Becofsky, PhD
UMass Amherst

Wed, 10/3/2018 - 4:00pm
221 Integrated Sciences Building

Dr. Becofsky is interested in the two major aspects of exercise psychology: 1) getting people to adopt and maintain active lifestyles, and 2) studying the mental health and cognitive benefits of exercise and physical activity.

Since most people do not like to exercise or find it difficult to fit into their busy lives, my research involves promoting activities that people enjoy and/or deeply value and that get them moving as a ‘side-effect’. Dr. Becofsky is also very interested in the mental, social, and physical health benefits of the human-animal bond, and specifically studying the effects of pairing people with companion dogs.

Dr. Becofsky is interested in working with any and all populations, but particularly those with the most to gain in terms of preserving/improving cognitive function, reducing symptoms of anxiety or depression, and reducing feelings of social isolation or loneliness.

Host: Janice C. Telfer, PhD

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Unraveling novel drivers of rampant genomic instability in breast cancer

Kate Fagan-Solis, PhD
UNC Chapel Hill

Wed, 9/26/2018 - 4:00pm
221 Integrated Sciences Building

Katerina Fagan-Solis, Ph.D. is a Senior Postdoc in the laboratory of Gaorav Gupta, MD/Ph.D. at the Lineberger Comprehensive Cancer Center at UNC Chapel Hill. She received her Ph.D. from the MCB Program at UMass Amherst in 2013 (Arcaro Lab).

Unraveling novel drivers of rampant genomic instability in breast cancer

Widespread chromosomal instability is a hallmark feature of Triple-Negative Breast Cancer (TNBC), yet the origins of this phenotype are poorly understood. To maintain genome integrity, cells have an elaborate DNA damage response (DDR) mechanism that functions to repair damaged DNA efficiently and commits cells to death if damage is irreparable. An important component of the DDR is the p53 pathway, which is altered in nearly all TNBC but is not currently therapeutically targetable. What is not known is whether alterations in p53-independent DDR mechanisms also drive tumorigenesis and rampant genomic instability in TNBC. Understanding these pathways is important because they may expose tumor-specific vulnerabilities in DNA repair that may be therapeutically exploited. We have developed a novel murine model of TNBC that leverages CRISPR/Cas9 to engineer specific DDR mutations of interest simultaneously with driver oncogenic mutations. Using this model, we demonstrate that deficiency in the Mre11 DDR pathway drives uncontrolled proliferation and genomic instability of TNBC through a p53-independent mechanism. We also observe Mre11 pathway deficiency in a subset of human TNBC, which correlates with increased sensitivity to specific types of DNA damaging chemotherapy. Thus, evaluating TNBC for deficiency in DDR pathway components beyond p53 represents an attractive opportunity for therapeutic exploitation.

Host: Kathleen Arcaro, PhD

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Novel Methods in the Investigation, Detection, and Control of Foodborne Viruses

Matthew D. Moore, PhD
UMass Amherst

Wed, 9/19/2018 - 4:00pm
221 Integrated Sciences Building

Background & Objectives: Human norovirus is the leading cause of foodborne illness and one of the leading causes of foodborne death globally—inflicting a considerable public health and economic burden. Despite recent advances, multiple hurdles related to noroviruses remain: I.) understanding viral pathogenesis in light of reports that enteric bacteria may assist norovirus infection, II.) rapidly and sensitively concentrating and detecting viruses from foods, and III.) controlling viral transmission with effective disinfectants and edible therapeutics. The goal of our work is to address all three of these challenges with novel approaches.

Methods & Results: The objectives were addressed using a variety of methods. I.) The degree and nature of norovirus-bacteria binding was characterized and candidate ligands identified; including a 35 kDa glycoprotein present in 7 enteric bacteria capable of broadly binding 6 norovirus genotypes. II.) Work to identify and produce bacteria capable of concentrating human norovirus has been completed, with observed capture efficiencies >75%. Application of an isothermal amplification technique, recombinase polymerase amplification, to the detection of epidemic human noroviruses resulted in sensitive, specific detection of virus in <20 minutes with promising tolerance to inhibitors in stool. III.) Development of techniques to understand viral inactivation mechanisms were successfully applied to silver dihydrogen citrate and copper. Nucleic acid aptamers, which show potential as therapeutics, were developed against an under-targeted viral protein necessary for replication. Initial reduction in replication by over 75% was observed.

Conclusions: Multiple challenges related to the I.) investigation, II.) detection, and III.) control of noroviruses were and continue to be addressed with novel techniques. I.) Identifying the bacterial ligand responsible for norovirus binding can reveal information about viral pathogenesis that allows for treatment/prevention. II.) Replacing paramagnetic beads with bacteria allows for cheap, scalable concentration of virus for detection with unprecedented efficiency. Application of true lab-in-a-suitcase technology for sensitive detection of norovirus in <30 minutes can mobilize detection and improve control. III.) Understanding viral inactivation allows for better identification of promising disinfectant formulations. Because most deaths occur from complications related to the severity of norovirus symptoms, inexpensive edible therapeutics capable of reducing viral replication/symptoms would likely reduce death.

Host: Cynthia Baldwin, PhD

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E1of1 is required for early mammalian development

Adam Tellier
UMass Amherst

Wed, 4/25/2018 - 4:00pm
221 Integrated Sciences Building

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Sperm in ART and Science

Pablo Visconti
UMass Amherst

Wed, 4/18/2018 - 4:00pm
221 Integrated Sciences Building

Host: Rafael Fissore, Ph.D.

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Can you translocate a protein while keeping it fully folded? In vitro studies of Peroxisomal Protein Import

Fabian B. Romano
Harvard Medical School

Wed, 4/11/2018 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, Ph.D.

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MicroRNA regulation of the immune system

Andrew William Grimson, Ph.D.
Cornell University

Wed, 4/4/2018 - 4:00pm
221 Integrated Sciences Building

Host: Leonid Pobezinsky

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From small to BIG: Emerging Nanotechnologies for Immunotherapy Applications

Ashish A. Kulkarni
UMass Amherst

Wed, 3/28/2018 - 4:00pm
221 Integrated Sciences Building

Host: Barbara A. Osborne, Ph.D.

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Redox stress and toxicological perturbation of pancreas development in the zebrafish embryo

Alicia Timme-Laragy
UMass Amherst

Wed, 3/21/2018 - 4:00pm
221 Integrated Sciences Building

Host: John Marshall Clark

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CANCELLED - The developmental layers of the CD8+ T cell response to infection

Brian D. Rudd, Ph.D.
Cornell University

Wed, 3/7/2018 - 4:00pm
221 Integrated Sciences Building

Host: Leonid Pobezinsky

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Unraveling the Cryptic Function of Deubiquitinases

Eric Strieter
UMass Amherst

Wed, 2/28/2018 - 4:00pm
221 Integrated Sciences Building

Host: Barbara A. Osborne, Ph.D.

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Understanding mammary gland biology through species comparison

Gat Rauner Postdoctoral Fellow Van de Walle lab, Baker Institute for Animal Health, College of Veterinary Medicine, Cornell, Ithaca
Cornell University

Wed, 2/14/2018 - 4:00pm
221 Integrated Sciences Building

Host: Joe Jerry, Ph.D.

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Segregating chromosomes in the early mammalian embryo

Greg Fitzharris
Université de Montréal

Wed, 2/7/2018 - 4:00pm
221 Integrated Sciences Building

Host: Rafael Fissore, Ph.D.

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CANCELLED - Functional Morphology of Marine Mammal Genitalia

Dara Orbach, Ph.D.
Dalhousie University

Wed, 1/31/2018 - 4:00pm
221 Integrated Sciences Building

Host: Heather Sherman, MCB Ph.D. Candidate

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Anicient and conserved multigenic arrays of Scavenger Receptor Cysteine Rich (SRCR) receptors determine the γδ T cell response to pathogens

Janice Telfer
UMass Amherst

Wed, 1/24/2018 - 4:00pm
221 Integrated Sciences Building

Host: VASCI ABBS Graduate Program

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Cooperative Regulation of RNA Binding Proteins and Alternative Splicing in CD8 T Cells by Notch1 and PKCtheta

Lisa Minter
UMass Amherst

Wed, 12/6/2017 - 4:00pm
221 Integrated Sciences Building

Host: ABBS Graduate Students

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Let’s control the immune response!

Leonid Pobezinsky
UMass Amherst

Wed, 11/15/2017 - 4:00pm
221 Integrated Sciences Building

Host: ABBS Graduate Students

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The Link between Microbiome and Mental Health

Alban Gaultier
University of Virginia

Wed, 11/8/2017 - 4:00pm
221 Integrated Sciences Building

Host: Dominique Alfandari

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Suprmam1_ alters mammary tumor penetrance in Li-Fraumeni Syndrome mouse models.

Prabin Kumar Dhangada Majhi
UMass Amherst

Wed, 11/1/2017 - 4:00pm
221 Integrated Sciences Building

Host: Joe Jerry

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Unraveling the Cryptic Function of Deubiquitinases

Eric Strieter
UMass Amherst

Wed, 10/25/2017 - 4:00pm
221 Integrated Sciences Building

Host: Barbara A. Osborne

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Global Analysis of Human Promoters Suggests a Mechanism Organizing Genome-wide Transcription

Sergei Nechaev, Ph.D.
University of North Dakota

Wed, 10/18/2017 - 4:00pm
221 Integrated Sciences Building

Host: Leonid Pobezinsky

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The 24-hour clock in our DNA

Joseph Takahashi, Ph.D.
UT Southwestern

Wed, 10/11/2017 - 4:00pm
ILC S240

Sinauer Lecturer hosted by Eric Bittman – Neuroscience and Behavior Graduate Program, Biology Dept.

Host: Eric Bittman

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Can Adult House Flies Serve as a Vector for the ORF Disease of Sheep and Goats?

John Stoffolano, Ph.D.
UMass Amherst

Wed, 10/4/2017 - 4:00pm
221 Integrated Sciences Building

Host: Katie Beltaire

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SFRP1: Changing the Landscape and Microenvironment of the Breast?

Sallie Smith-Schneider, Ph.D.
Baystate Medical Center
Biospecimen Resource and Molecular Analysis Facility Baystate Medical Center

Wed, 9/27/2017 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro

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Anti-inflammatory effects of bacterial exopolysaccharide

Katherine Knight, Ph.D.
Loyola University

Wed, 9/20/2017 - 4:00pm
221 Integrated Sciences Building

Dr. Knight is the Chair of the Department of Microbiology and Immunology at the Loyola University School of Medicine.

Host: Barbara A. Osborne

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Characterization of the porcine WC1 gene array and its role in the immune response to mycobacterium

Lauren Le Page
UMass Amherst

Wed, 9/13/2017 - 4:00pm
221 Integrated Sciences Building

Lauren LePage is an ABBS Ph.D. candidate in the Telfer lab.

Host: VASCI ABBS Graduate Program

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Characterization of Dnaaf2 Knockout Mouse Embryos

Agnes Cheong
UMass Amherst

Wed, 9/13/2017 - 4:00pm
221 Integrated Sciences Building

Agnes Cheong is an ABBS Ph.D. candidate in the Mager lab

Host: VASCI ABBS Graduate Program

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Regulation of Metabolism by Notch in Peripheral CD4+ T Cells

Ankita Mitra, Ph.D. candidate
UMass Amherst

Wed, 4/26/2017 - 4:00pm
221 Integrated Sciences Building

Host: VASCI ABBS Graduate Program

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Regulation of Ca2+ Influx in GV Mouse Oocytes

Goli Ardestani, Ph.D. candidate
UMass Amherst

Wed, 4/26/2017 - 4:00pm
221 Integrated Sciences Building

Host: VASCI ABBS Graduate Program

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It Takes Guts to Live in a Cave: the Blind Cavefish, Astyanax Mexicanus, as a Model to Study the Development and Evolution of the Gastrointestinal Tract

Misty Riddle, Ph.D
Harvard University
Harvard University Cliff Tabin lab

Wed, 4/12/2017 - 4:00pm
221 Integrated Sciences Building

Host: Hélène Cousin, Ph.D.

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T Cell Immunity to Tuberculosis

Samuel Behar, M.D., Ph.D.
UMass Medical

Wed, 4/5/2017 - 4:00pm
221 Integrated Sciences Building

Host: Cynthia Baldwin, Ph.D.

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Looking at Disease in a New Light: Chemical Biology-Enabled Tools and Platforms for Studying Cancer

Michele Farkas, Ph.D.: Farkas Group
UMass Amherst

Wed, 3/29/2017 - 4:00pm
221 Integrated Sciences Building

My laboratory is interested in developing and applying chemical biology methods for the study, imaging, and treatment of cancer. Our overall goals are to develop detectable, trackable platforms that we can use to visualize biological phenomena, and generate scaffolds to perturb and probe those systems using chemical strategies.

Host: Pablo Visconti, Ph.D.

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Epigenetic Regulation of Imprinting During Mammalian Development

Jesse Mager
UMass Amherst

Wed, 3/22/2017 - 4:00pm
221 Integrated Sciences Building

Host: VASCI ABBS Graduate Program

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DNA Methylation on the Continuum from Normal Breast to Breast Cancer

Brock Christensen, Ph.D.: Christensen Lab
Dartmouth University

Wed, 3/8/2017 - 4:00pm
221 Integrated Sciences Building

Our molecular epidemiology research program is focused on epigenetic states across the continuum from normal cellular states to pre-invasive, and invasive cancers. Our goals include advancing the understanding of how risk factors for cancers including aging and exposures are related with DNA methylation alterations in normal tissues, as well as identifying patterns of DNA methylation in tumors that are related with patient outcomes.

Host: Kathleen F. Arcaro

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Enhancing Resistance to Animal African Trypanosomiasis

Samuel J. Black, Ph.D
UMass Amherst

Wed, 2/15/2017 - 4:00pm
221 Integrated Sciences Building

Abstract: Tsetse flies are endemic to the humid and semi-humid regions of Africa, a landmass of 10 million km2 that encompasses vast swaths of prime agricultural land suited to rain fed agriculture. Tsetse flies feed on mammal blood and transmit African trypanosomes in their saliva. The inoculated flagellated protozoans invade and multiply in the host blood plasma causing animal African trypanosomiasis (AAT), which is endemic throughout the tsetse habitat and fatal in cattle and other livestock species, but tolerated by Cape buffalo and other wildlife species with which African trypanosomes co-evolved and which serve as reservoir hosts. African trypanosomes change their variable surface glycoprotein (VSG) coat infrequently and stochastically, hence as each wave of parasites grows in the blood and is eliminated by the host immune response, new variants remain to seed the next parasitemic wave. In cattle and other trypanosomiasis-susceptible hosts this process results in recurring waves of trypanosomes in the blood, accompanied by recurring waves of co-lateral damage to the host cumulating in wasting and death. Trypanosome antigenic variation has so far prevented the development of an effective vaccine against AAT, which remains a major contributor to food insufficiency in sub-Saharan Africa. Dr. Black has worked on mechanisms of host control of AAT for the last 36 years, many of which were spent in Kenya studying how African Cape buffalo control the disease, and all of which were invested in discovering how to curb the severity of AAT in susceptible hosts. The seminar will review this scientific journey, and report progress towards understanding the mechanism of AAT induced pathogenesis and its control.

Host: Leonid Pobezinsky, Ph.D.

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Colocalizaton of γδ TCR with the WC1 Pathogen Recognition Receptor/Coreceptor

Alie Gillespie, Ph.D. candidate
UMass Amherst

Wed, 2/8/2017 - 4:00pm
221 Integrated Sciences Building

Host: VASCI ABBS Graduate Program

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Molecular Cloning and Initial Characterization of Radial Spoke Head 6 Homolog A (Rsph6a): A Novel Role in Mouse Sperm Physiology

Bidur Paudel, Ph.D. candidate
UMass Amherst

Wed, 2/8/2017 - 4:00pm
221 Integrated Sciences Building

Host: VASCI ABBS Graduate Program

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Host-Pathogen Interaction: the Role of the Human Microbiome in Health and Disease Using Next-Generation Sequencing

Ravi Ranjan, Ph.D.
UMass Amherst
Institute for Applied Life Sciences Genomics Resource Laboratory

Wed, 2/1/2017 - 4:00pm
221 Integrated Sciences Building

Host: Cynthia Baldwin, Ph.D.

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Prion Biology: At the Interface Between Protein Misfolding and Its Cellular Environment

Tricia Serio, Ph.D.
UMass Amherst

Wed, 1/25/2017 - 4:00pm
Location: TBA

Host: Department of Biochemistry and Molecular Biology

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“Fluid Dynamic Implications in Vascular Disease and Development”

Juan M. Jiménez Ph.D.
UMass Amherst

Wed, 12/7/2016 - 4:00pm
221 Integrated Sciences Building

Bodily fluids (e.g. blood, lymph) serve an important role in transport of molecules in cells and the body. Fluid transport can affect development and disease progression. Our laboratory studies the fundamentals of fluid flow dynamics that are relevant in biomedicine, merging engineering and molecular biology techniques to study cardiovascular disease, implantable device design, and lymphatic vessel development. For example, cardiovascular stents allow re-establishment of blood flow to a blocked coronary artery, however their design may contribute to morbidity and mortality. Both experimentally and numerically we have demonstrated that by introducing aerodynamic principles into stent strut design and creating a streamlined stent strut, the risk of thrombus formation is decreased and a healthier, anti-thrombotic endothelial phenotype ensues, important markers of clinical success. In the lymphatic system, we have demonstrated the importance of fluid flow in the development of lymphatic valves. Decreased fluid flow leads to impaired (or lack of) valve formation with downregulation of important genes, resulting in lymphedema.

Dr. Juan Jiménez is a Biomedical Engineering Assistant Professor in the Mechanical & Industrial Engineering Department at the University of Massachusetts. He received a B.S. degree in Mechanical Engineering from Michigan State University and a M.S. and Ph.D. in Mechanical and Aerospace Engineering from Princeton University. His Ph.D. work focused on turbulence conducting the highest Reynolds number wake measurements ever conducted. He transitioned to the University of Pennsylvania’s Institute for Medicine and Engineering as a postdoctoral fellow to study the effects of fluid flow on implantable biomedical devices like stents. After his postdoctoral fellowship, he stayed at Penn as a faculty member in the Department of Pathology & Laboratory Medicine at the School of Medicine. He is also a recipient of a prestigious NIH K25 Mentored Quantitative Research Career Development Award.

Host: Barbara A. Osborne, Ph.D.

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Genetically engineered animal models: our recent successes in applying the CRISPR/Cas9, TALEN, and piggyBac systems to non-murine species

Zhongde Wang, Ph.D.
Utah State University

Wed, 11/9/2016 - 4:00pm
221 Integrated Sciences Building

Host: Joseph Jerry, Ph.D.

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“Investigating the mechanisms of crossover control during mammalian meiosis”

Paula Cohen Ph.D.: The Cohen Lab
Cornell University

Wed, 11/2/2016 - 4:00pm
221 Integrated Sciences Building

Host: Rafael A. Fissore, Ph.D.

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Dynamic Organization of the Plasma Membrane in Mammalian Cells

Diego Krapf, Ph.D.: Krapf Lab
Colorado State University

Wed, 10/26/2016 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, Ph.D.

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"The mating game in flowering plants; How do non motile sperm get to the egg cell for fertilization?"

Alice Cheung, Ph.D.
UMass

Wed, 10/19/2016 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, Ph.D.

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“Role of the linear ubiquitination assembly complex in the regulation of lung injury and inflammation

Laura Dada, PhD, Division of Pulmonary and Critical Care Medicine
Northwestern University

Wed, 10/12/2016 - 4:00pm
221 Integrated Sciences Building

The major goal of our research is to study the role of the Na,K-ATPase subunits in the regulation of alveolar epithelial function in normal and hypoxic conditions. We will shift the emphasis from the transport function of the Na,K-ATPase to its important role in stabilizing intercellular junctions and hence in alveolar epithelial integrity. Hypoxemia and injury of the alveolar-capillary barrier might result not only in a decrease in Na,K-ATPase activity but also in weakening interactions between the Na,K-ATPase ß1 subunits in neighboring cells. We will determine the molecular mechanisms regulating these ß1:ß1 interactions and design strategies to strengthen them as a way to enhance the function of the alveolar epithelial barrier. We are also interested in the role of FXYD5, which regulates cell-cell adhesion and the integrity of the alveolar epithelium by inhibiting the intercellular interaction between the Na,K-ATPase ß1 subunits of neighboring cells in a competitive mode. Given the fact that FXYD proteins are expressed and interact with the Na,K-ATPase in a tissue-specific way, understanding the molecular mechanisms of FXYD5-mediated regulation of ß1:ß1 interactions and thus alveolar epithelial barrier function may lead to novel, more effective treatment of acute lung injury.

Host: Pablo Visconti, Ph.D.

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"Signaling networks that control synapse development and cognitive function"

Dr. Michael Greenberg
Harvard University School of Medicine

Wed, 10/5/2016 - 4:00pm
151 Integrated Learning Center

Dr. Michael Greenberg is a Nathan Marsh Pusey Professor of Neurobiology at Harvard University School of Medicine. He will present a talk "Signaling networks that control synapse development and cognitive function" on Wednesday, October 5, 2016 at 4:00pm in the Integrated Learning Center room 151 as part of the Sinauer Seminar Series.

Event Contact: Zander Crowley

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Cell envelope biosynthesis in mycobacteria

Yasu Morita
UMass Amherst

Wed, 9/28/2016 - 4:00pm
221 Integrated Sciences Building

Dr. Morita's research focuses on the biosynthesis and regulation of glycolipids and other cell envelope components in mycobacteria. I will discuss two topics: 1) discovery of a novel periplasmic protein involved in the regulation of glycolipid biosynthesis, and 2) discovery of a unique membrane domain associated with polar elongation of the cell envelope.

Host: Cynthia Baldwin, Ph.D.

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"Cytokines and lymphoid cells as critical players in tumor elicited inflammation"

Sergei Grivennikov, Ph.D.
Fox Chase Cancer Ctr.

Wed, 9/21/2016 - 4:00pm
221 Integrated Sciences Building

Host: Leonid Pobezinsky

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Development of Nanomaterials for Therapeutic Delivery

Sankaran Thayumanavan, Ph.D.: Thayumanavan Research Group
UMass Amherst

Wed, 4/13/2016 - 4:00pm
221 Integrated Sciences Building

Host: ABBS Graduate Students

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Evaluating the Physiological Roles of ERa Functional Domains

Kenneth Korach, Ph.D.: Reproductive and Developmental Biology
NIEHS

Wed, 4/6/2016 - 4:00pm
221 Integrated Sciences Building

Dr. Korach has been a leader in the development of genetically modified mouse models to understand the complex biology of estrogen receptor signaling and its effects on diverse tissues. His lab has also been influential in defining the activities of a host of environmental agents that can impact on estrogen signaling resulting in infertility and toxicity.

Dr. Korach leads the Receptor Biology Group within the Laboratory of Reproductive and Developmental Toxicology. He received his Ph.D. in endocrinology from the Medical College of Georgia. He has edited four books and published 280 peer-reviewed articles in leading biomedical journals as well as several book chapters. He served as a Ford Research Fellow at Harvard Medical School before joining NIEHS in 1976.

Host: Joseph Jerry, Ph.D.

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This Seminar has been cancelled. - Fluid Dynamic Implications in Vascular Disease and Development

Juan Jiménez, Ph.D: Jiménez Lab
UMass Amherst

Wed, 3/30/2016 - 4:00pm
221 Integrated Sciences Building

Bodily fluids (e.g. blood, lymph) serve an important role in transport of molecules in cells and the body. Fluid transport can affect development and disease progression. Our laboratory studies the fundamentals of fluid flow dynamics that are relevant in biomedicine, merging engineering and molecular biology techniques to study cardiovascular disease, implantable device design, and lymphatic vessel development. For example, cardiovascular stents allow re-establishment of blood flow to a blocked coronary artery, however their design may contribute to morbidity and mortality. Both experimentally and numerically we have demonstrated that by introducing aerodynamic principles into stent strut design and creating a streamlined stent strut, the risk of thrombus formation is decreased and a healthier, anti-thrombotic endothelial phenotype ensues, important markers of clinical success. In the lymphatic system, we have demonstrated the importance of fluid flow in the development of lymphatic valves. Decreased fluid flow leads to impaired (or lack of) valve formation with downregulation of important genes, resulting in lymphedema.

Dr. Juan Jiménez is a Biomedical Engineering Assistant Professor in the Mechanical & Industrial Engineering Department at the University of Massachusetts. He received a B.S. degree in Mechanical Engineering from Michigan State University and a M.S. and Ph.D. in Mechanical and Aerospace Engineering from Princeton University. His Ph.D. work focused on turbulence conducting the highest Reynolds number wake measurements ever conducted. He transitioned to the University of Pennsylvania’s Institute for Medicine and Engineering as a postdoctoral fellow to study the effects of fluid flow on implantable biomedical devices like stents. After his postdoctoral fellowship, he stayed at Penn as a faculty member in the Department of Pathology & Laboratory Medicine at the School of Medicine. He is also a recipient of a prestigious NIH K25 Mentored Quantitative Research Career Development Award.

Host: Barbara Osborne, Ph.D.

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Regulated protein degradation during bacterial growth.

Peter Chien, Ph.D.: Chien Lab
UMass Amherst

Wed, 3/23/2016 - 4:00pm
221 Integrated Sciences Building

Host: ABBS Graduate Students

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Complex roles of ADAM metalloproteases during Cranial Neural Crest cell migration.

Dominique Alfandari, Ph.D.: Alfandari Lab
UMass Amherst

Wed, 3/9/2016 - 4:00am
221 Integrated Sciences Building

Host: ABBS Graduate Students

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Plastic Bodies in a Plastic World: What Environmental Contaminants Tell Us About Development.

Laura Vandenberg, Ph.D.
UMass Amherst

Wed, 3/2/2016 - 4:00pm
221 Integrated Sciences Building

Host: ABBS Graduate Students

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Nature-Inspired Materials Design

Sarah Perry, Ph.D.: Perry Research Group
UMass Amherst

Wed, 2/24/2016 - 4:00pm
221 Integrated Sciences Building

The diversity and complexity of both structure and function in biological macromolecules is driven by precisely balanced interactions. Charge-driven interactions are particularly key in biological systems, affecting not only protein folding, but also the formation of larger molecular assemblies and even the formation of intracellular organelles. Non-specific electrostatic interactions between proteins may also play an important role in modulating protein stability and activity, but a detailed understanding of these effects is still lacking.
Polyelectrolyte complexation provides an ideal platform to study the self-assembly of a wide range of soft materials ranging from dehydrated thin film and bulk solids to dense, polymer-rich liquid complex coacervates, and more complex hierarchical structures such as micelles and hydrogels. Factors that affect the self-assembly of these materials include the ratio of polycation to polyanion, temperature, pH, salt concentration, stereochemistry, polymer architecture, and the density and/or patterning of charges present. Among these factors, the ability to pattern charges and other chemical functionalities represents a powerful strategy for the design and manipulation of material properties. We use polypeptide-based materials as a model platform for understanding the self-assembly of charged biological molecules, and apply this strategy to understanding how the material environment affects protein stability. Ultimately, the goal of our investigation is to elucidate design rules that facilitate the tailored creation of materials based on polyelectrolyte complexation with defined properties for a wide range of applications, including stabilized vaccines and therapeutics.

Host: Ana Maria Salicioni, Ph.D

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SIM2s Regulation of the DNA Damage Response and Metabolic Adaptation in DCIS Progression

Weston Porter, Ph.D
Texas A & M
Genetics - Weston Porter

Wed, 2/17/2016 - 4:00pm
221 Integrated Sciences Building

The incidence of breast ductal carcinoma in situ (DCIS) has increased dramatically as a result of screening mammography; however, there are gaps in our understanding of which lesions will become invasive and the mechanisms regulating recurrence and progression. Senescence and metabolism play key roles in breast cancer progression. Though bypass of senescence and metabolic adaptation are hallmarks of cancer progression, there is little if any evidence that these two critical pathways are mechanistically linked in DCIS progression. We have shown that Singleminded-2s (SIM2s; expressed from SIM2), a member of the bHLH/PAS family of transcription factors, is a tumor suppressor down-regulated in Transition from DCIS to IDC. Our recent results indicate that SIM2s is a potent inducer of senescence and the DNA damage response pathway and oxidative phosphorylation in breast cancer, and does so by directly regulating p21WAF1 independent of p53. Thus,suggesting that SIM2s is a tumor suppressor that blocks DCIS progression by regulating senescence-metabolic equilibrium.
Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s).
Scribner KC, Behbod F, Porter WW. Oncogene. 2013 May 23;32(21):2631-9. doi: 10.1038/onc.2012.286. Epub 2012 Jul 9.PMID: 22777354
Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFκB.
Scribner KC, Wellberg EA, Metz RP, Porter WW.Mol Endocrinol. 2011 Apr;25(4):635-44. doi: 10.1210/me.2010-0423. Epub 2011 Feb 3. PMID: 21292822
The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation. Wellberg E, Metz RP, Parker C, Porter WW. Development. 2010 Mar;137(6):945-52. doi: 10.1242/dev.041657. Epub 2010 Feb 11. PMID: 20150276

Host: Joseph Jerry, Ph.D.

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Herding bacteria: how a eukaryotic host controls its microbial partners

Dong Wang, Ph.D.
UMass Amherst

Wed, 2/3/2016 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti

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"Genetics of Fertility in Mice and Humans"

John Schimenti, Ph.D. Professor of Genetics; Director, Center for Vertebrate Genomics
Cornell University

Wed, 12/9/2015 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti

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"Developmental shift or postnatal plasticity? Manual and pedal variation in two populations of Microcebus griseorufus at Bezà Mahafaly"

Gina Agostini
UMass Amherst

Wed, 11/18/2015 - 4:00pm
221 Integrated Sciences Building

Abstract: Under the "Narrow Niche Hypothesis" (NNH), long posterior digits are adaptive in arboreal environments to facilitate grasping thin, unstable branches.Microcebus griseorufus is a small primate residing primarily in xeric forests in southern Madagascar. We compare neighboring M. griseorufus populations to investigate whether autopod proportions conform to NNH expectations. One population resides in a gallery forest containing numerous wide-canopied trees, small branches and abundant foliage, the other population in a spiny forest with more vertically-oriented succulents, large supports and less ground cover. Previous research indicates these populations are phenotypically diverse but genetically similar. All data were collected by Dr. Emilienne Rasoazanabary. Results show that digit proportions conform to the expectations of the Narrow Niche Hypothesis. Specifically, individuals from the gallery forest possess dis-proportionally long posterior digits and a shorter pollex/hallux, while individuals from the spiny forest possess shorter posterior digits and a longer pollex/hallux. This pattern was present for both hands and feet in both sexes and in juveniles. Furthermore, results of a Qst analysis indicate divergence between these two subpopulations despite contrary evidence in mitochondrial DNA analyses. We present two proximate pathways by which these contrasting patterns could arise: [1] postnatal plasticity stimulated by differing locomotor strategies and [2] developmental shifts regulated by currently unknown genetic or epigenetic factors. The strengths and weaknesses of both will be presented.

Host: Hélène Cousin, Ph.D.

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This Seminar has been CANCELLED, - “ADAM8 is a Target for Treatment of Triple-Negative Breast Cancer”

Gail E. Sonenshein, Ph.D.: The Gail Sonenshein Lab
Tufts University

Wed, 11/4/2015 - 4:00pm
221 Integrated Sciences Building

Host: Joseph Jerry, Ph.D.

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What the UMass Libraries Can Do for You

Laura Quilter, M.S., J.D.
UMass Amherst
Laura Quilter, Copyright and Information Policy Librarian

Wed, 10/28/2015 - 4:00pm
221 Integrated Sciences Building

As an attorney and librarian, Laura Quilter educates the campus community on copyright and related matters.

Host: Lisa Minter, Ph.D.

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"New Paradigms of Host Resistance to African Trypanosomiasis "

John Mansfield, Ph.D.
University of Wisconsin-Madison

Wed, 10/21/2015 - 4:00pm
221 Integrated Sciences Building

Research Summary: Research in the Mansfield laboratory focuses on the complex immunobiological relationship between host and parasite in African trypanosomiasis, a fatal protozoan disease of man and animals.
Initial studies examined the immunogenetics of resistance to disease by utilizing genetically altered host animals and genetically modified trypanosomes. These studies showed that CD4 T cells and interferon gamma play an important role in control of disease progression. Recent work in the Mansfield laboratory has determined the impact of immunization with relatively conserved C terminal peptides of the trypanosome's variable surface glycoprotein coat on Trypanosome brucei-induced CD4 T cell recall responses and interferon gamma production. Strikingly, CD4 T cell interferon gamma responses against the conserved VSG peptides, which were absent in naive infected mice, were strongly present in the immunized infected mice. Furthermore these immunized mice did not develop trypanosomiasis-associated pathology. Future studies are aimed at optimizing this recall CD4 T cell response to control or cure trypanosomiasis.

Host: Samuel J. Black, Ph.D.

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"X-marks the spot: Targeting the Drosophila dosage compensation complex."

Erica Larschan, PhD: Larschan Lab
Brown University

Wed, 10/14/2015 - 4:00pm
221 Integrated Sciences Building

Host: Jesse Mager, Ph.D.

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"Modulation of Notch signaling in T cells restores anti-tumor responses and enhances immunotherapy efficacy in cancer"

Paulo C. Rodriguez, PhD - LSU School of Medicine, Department of Microbiology, Immunology & Parasitology
Louisiana State University

Wed, 10/7/2015 - 4:00pm
221 Integrated Sciences Building

Research in Dr. Rodriguez’s laboratory focuses on understanding mechanisms underlying the inhibition of immune responses in tumor-bearing hosts, in generating new therapies to overcome tumor-induced immune suppression, and to enhance efficacy of different forms of immunotherapy. The long-term goal is to develop new strategies to restore protective immunity in cancer, leading to long-lasting anti-tumor effector T cell responses.

Host: Barbara Osborne, Ph.D.

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MANIPULATION OF THE MOUSE GENOME: CRISPR VERSUS THE OLD FASHION WAY

Siu-Pok Yee, Ph.D. Assistant Professor, Genetics and Genome Sciences
University of Connecticut Health Center

Wed, 9/30/2015 - 4:00pm
221 Integrated Sciences Building

Host: Rafael Fissore

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"Cause of elevated aneuploidy levels and human infertility: Role of a germ-cell specific Aurora kinase"

Karen Schindler, Ph.D.: Schindler Lab
Rutgers University

Wed, 9/23/2015 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti

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"Using synthetic and biosynthetic collections of small molecules to discover unique modulators of protein function"

Sergey Savinov, Ph.D.
UMass Amherst

Wed, 4/29/2015 - 4:00pm
221 Integrated Sciences Building

Host: Ana Maria Salicioni, Ph.D.

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"The SL03 potassiam Channel: A key player in sperm capacitation"

Celia Santi, MD, Ph.D.
"Washington University, St. Loius, MO

Wed, 4/8/2015 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, Ph.D

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"Developmental Symbiosis: Opening the doors to a new developmental biology"

Scott Gilbert, Ph.D.
Swarthmore College

Wed, 4/1/2015 - 4:00pm
221 Integrated Sciences Building

Host: Hélène Cousin, Ph.D.

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"Antibody drug conjugates: the long road from concepts to reality"

Jan Pinkas, Ph.D.
Immunogen, Inc.

Wed, 3/25/2015 - 4:00pm
221 Integrated Sciences Building

Jan Pinkas is a graduate of the University of Massachusetts Molecular and Cellular Biology Graduate Program. During his dissertation research with Joseph Jerry's lab group, he focused on regulation of the p53 tumor suppressor pathway by MDM2. Jan was a postdoctoral fellow with Philip Leder at Harvard. He has worked extensively in development of novel cancer therapies with pharmaceutical companies. He has also led the effort to develop maytansinoid derivatives, small molecule drugs, at ImmunoGen and collaborating with Genentech to create a first in its class conjugate with anti-EGFR antibodies. Jan will present not only the exciting data supporting this newly approved drug (Kadcyla™), but the long road to FDA approval.

Host: Joseph Jerry, Ph.D.

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"Metastatic Dormancy: Sleeping like an egg"

Tsukasa Shibue, Ph.D.
Whitehead Institute, MIT

Wed, 3/11/2015 - 4:00pm
221 Integrated Sciences Building

Host: Richard Goldsby, Ph.D.

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"Sperm sees it hot: Sperm guidance in mammals"

Michael Eisenbach, Jack and Simon Djanogly Chair in Biochemistry
Weizmann Institute, Isreal

Wed, 3/4/2015 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti, Ph.D

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"Do muscles fight cancer? A story of post-mitotic tissues and discovery"

Zuzana Keckesova, Ph.D.
Whitehead Institute

Wed, 2/25/2015 - 4:00pm
221 Integrated Sciences Building

Host: Richard Goldsby, Ph.D.

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"Shedding light on equine laminitis: Proteomic and histologic studies of the hoof lamellar microanatomy"

Hannah Galantino-Homer, VMD, PhD, DACT
UPenn

Wed, 2/18/2015 - 4:00pm
221 Integrated Sciences Building

Seminar Abstract
The epidermal-dermal interface between the equine hoof capsule and underlying dermal corium is a key element of the suspensory apparatus of the distal phalanx, is formed by hundreds of interdigitating primary and secondary dermal and epidermal lamellae, and undergoes damage and failure in horses afflicted with laminitis. My laboratory is interested in the microanatomical, cellular, and molecular events of laminitis pathogenesis. An initial discovery mode quantitative proteomic study of lamellar tissue from an experimental induction model of laminitis resulted in the identification of a tissue-specific, novel keratin isoform pair and several differentially expressed proteins. The identified differentially expressed proteins are consistent with histologic evidence of altered tissue differentiation and cell stress during laminitis pathogenesis. In particular, we have examined changes in the abundance and localization of the cytoskeletal intermediate filament protein, keratin-14, and the cytolinker protein, desmoplakin. Our recent development of a lectin-based fluorescent counterstain for equine lamellar tissue has allowed us to more precisely localize changes in the expression and localization of keratin-14, desmoplakin, and other structural and adhesion proteins in laminitic and control horses. Altered keratin-14 expression correlates with changes in desmoplakin subcellular localization. These studies contribute to building evidence that the epidermal lamellae play an integral role in laminitis pathogenesis and the mechanical failure of the digit.

Dr. Galantino-Homer is a graduate of Swarthmore College and the Veterinary Medical Scientist Training Program at the University of Pennsylvania. She received her veterinary degree from the School of Veterinary Medicine in 1993 and her doctor of philosophy degree in Cell and Developmental Biology from Biomedical Graduate Studies in 2000 under the mentorship of Greg Kopf of the Center for Research on Reproduction and Women’s Health on signaling events associated with bovine sperm capacitation. She continued studies of bovine and porcine sperm capacitation, cryopreservation, and cryocapacitation in Ina Dobrinski’s laboratory at the Center for Animal Transgenesis and Germ Cell Research at New Bolton Center and also became a diplomate of the American College of Theriogenologists in 2004. Dr. Galantino-Homer was appointed Senior Research Investigator in Laminitis at New Bolton Center in 2007 and has established a basic research laboratory for molecular and in vitro investigations of laminitis pathogenesis.

Host: Samuel Black, Ph.D.

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"Gecko adhesion; How do we get from small to big?"

Duncan Irschick, Ph.D.
UMass Amherst

Wed, 2/11/2015 - 4:00pm
221 Integrated Sciences Building

Host: Hélène Cousin, Ph.D.

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"Modulation of the allergic response - roles of dietary components and regulatory cytokines"

Clinton Mathias, Ph.D.
Western New England College of Pharmacy
WNE College of Pharmacy Faculty

Wed, 2/4/2015 - 4:00pm
221 Integrated Sciences Building

Host: Barbara Osborne, Ph.D.

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“TNF signaling: essential players”

Elena Pobezinskaya, Ph.D.,
UMass Amherst

Wed, 12/3/2014 - 4:00pm
221 Integrated Sciences Building

Host: Barbara Osborne, Ph.D.

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“Mechanisms underlying increased lifespan through nutrient composition and mRNA translation”

Aric Rogers, Ph.D.
Rogers Laboratory Davis Center for Regenerative Biology and Medicine

Wed, 11/19/2014 - 4:00pm
221 Integrated Sciences Building

Our lab uses the small roundworm C. elegans to study how gene expression is remodeled under conditions that extend lifespan, particularly at points of regulation that occur after transcription. Genetic variations and environmental conditions that result in lifespan extension are also associated with delaying the onset of age-related diseases including diabetes, cancer, and neurodegeneration. The goal of our lab is to understand how life-extending interventions work across different species and apply what is learned to extend human health and longevity.

Host: Barbara Osborne, Ph.D.

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"Human pluripotent cells for personalized medicine and teratogen analysis"

Theodore Rasmussen, Ph.D.
Rasmussen Lab UConn

Wed, 11/5/2014 - 4:00pm
221 Integrated Sciences Building

The Rasmussen Laboratory at the University of Connecticut conducts basic and applied stem cell research that is designed to bring about advances in human health. The research methodologies utilized in the lab are drawn from stem cell science, epigenetics and chromatin dynamics, functional genomics, proteomics, molecular genetics, cell biology, and cell-based screening. Three major research objectives are under active investigation:

translational research involving cellular reprogramming to develop cell culture models for the study of human genetic disorders; production and use of patient-matched iPS stem cells for use in personalized medicine research;
basic research on mechanisms involving epigenetics and chromatin to gain a deeper understanding of stem cell differentiation and cellular reprogramming.

Long-range goals of the lab include the development of improved methods for the guided differentiation of human pluripotent cells to yield autologous transplantable cells with therapeutic properties. Another goal is to use patient-matched cells as a platform for personalized pharmacology and individualized determinations of treatment safety and efficacy. Dr. Rasmussen also investigates epigenetic function during mammalian gametogenesis, preimplantation development, and X chromosome inactivation.

Host: Jesse Mager, Ph.D.

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"Bottoms up: next generation analyses for high dimensional data"

Jacob Mayfield, Ph.D.
UMass

Wed, 10/29/2014 - 4:00pm
221 Integrated Sciences Building

High throughput data (-omics) produces huge lists of measurements for every sample. How can ten thousand rows turn into testable hypotheses? The familiar statistical methods that work well for single, known entities (supervised or top down analysis using T tests) are insufficient for discovering unknown patterns (unsupervised or bottom up analysis). I will discuss projects where contemporary statistics uncovered unexpected results, including a study of the human metabolic disease homocystinuria, a search for rare mutations using next generation sequencing, and the lipidomics of multidrug resistance in Mycobacterium tuberculosis.

Host: Rafael Fissore, Ph.D.

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"Calcium signaling in response to cell stretch"

Erin Cram, Ph.D
Cram Lab at Northeastern University

Wed, 10/22/2014 - 4:00pm
221 Integrated Sciences Building

Interactions between cells and their extracellular environment play an essential role in controlling tissue architecture, cell survival, and cell migration. These processes are important for normal animal development and are disrupted in many human diseases. The Cram lab uses the nematode C. elegans to investigate the conserved processes that control cell migration and mechanotransduction in vivo. In collaboration with Chemical Engineers, we are also working to improve production of drug compounds by the medicinal plant Catharanthus roseus.

Host: Dominique Alfandari, Ph.D

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"How to build new organs from old cells: using the amphibian limb regenerate to study endogenous cell reprogramming”

Catherine McCusker, Ph.D.
UC Irvine

Wed, 10/8/2014 - 4:00pm
221 Integrated Sciences Building

Salamanders have the amazing capacity to dedifferentiate and reprogram adult somatic cells to generate a pool of progenitor cells (called blastema cells) that will replace missing structures, such as amputated limbs. In this talk I will discuss how the tissue microenvironment controls the reprogramming of pattern information in limb blastema cells, and how this process can be manipulated in a predictable way. I will then discuss how what we have learned about amphibian limb regeneration could apply to improving cell-based regenerative medicine in humans.

Host: Dominique Alfandari, Ph.D

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“Resumption of ovarian cyclicity in the postpartum dairy cow: An endocrine dysfunction.”

Soon Hon Cheong, DVM, PhD
Cornell University

Wed, 10/1/2014 - 4:00pm
221 Integrated Sciences Building

Dr. Cheong will be exploring the resumption of ovarian cyclicity in postpartum dairy cows and the characteristics of cows that fail to ovulate.

Host: Katherine Beltaire, Ph.D.

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"Novel regulators of liver development and regeneration"

Wolfram Goessling, M.D, Ph.D.
Harvard Medical School
Goessling & North Labs

Wed, 9/24/2014 - 4:00pm
221 Integrated Sciences Building

Developmental signaling pathways govern the formation and function of stem cells, thereby holding the key to unlocking the promise of adult tissue regeneration, and to inhibiting cancer development. In our laboratory, we use zebrafish as the primary model to study the liver and explore the regulation of endodermal progenitor cell specification, organ differentiation and growth. We then examine the conserved role of these signaling pathways in regulating tissue growth in surgical and chemical models of liver regeneration and genetic liver cancer models. We also use murine liver injury models to demonstrate evolutionary conservation and relevance for human disease. Our prior work has shown that we can translate our findings from the fish tank to the bedside, as the first clinical trial originating from our findings in the fish has begun to enroll patients.

Host: Kimberly Tremblay, Ph.D.

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Structurally distinct Ca2+ domain of sperm flagella orchestrate tyrosine phosphorylation and motility

Jean-Ju Chung
Children’s Hospital Boston, Harvard Medical

Wed, 4/30/2014 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti

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Nursing our bacterial selves: the genomics and physiology of milk utilization by our earliest commensals

David Sela, Ph.D.
UMass - Amherst

Wed, 4/16/2014 - 4:00pm
221 Integrated Sciences Building

Host: Kathleen Arcaro, Ph.D.

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Building a brain in the gut: molecular regulation of ENS development in the colon

Allan Goldstein M.D.
Mass General Hospital

Wed, 4/9/2014 - 4:00pm
221 Integrated Sciences Building

Host: Kimberly Tremblay, Ph.D.

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Transcriptional Modulation of Nodal Signaling by Fox and Groucho Proteins.

Daniel Kessler Ph.D.
UPenn, Phildelphia

Wed, 4/2/2014 - 4:00pm
221 Integrated Sciences Building

Host: Dominique Alfandari, Ph.D

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Orchestrating early embryonic development: Dynamic gene expression in the neural crest

Lisa Taneyhill Ph.D.
University of Maryland

Wed, 3/26/2014 - 4:00pm
221 Integrated Sciences Building

Host: Hélène Cousin, Ph.D.

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Human Disorders of Cohesin

Matt Deardorff M.D. Ph.D
UPenn, Children's Hospital of Philidelphia

Wed, 3/12/2014 - 4:00pm
221 Integrated Sciences Building

Matt obtained his MD/PhD at UPenn, focusing on Wnt signaling during frog development. He then did a residency in Pediatrics and a Genetics Fellowship at CHOP.

As an Assistant Professor of Pediatrics at Penn, his research has focused on understanding the genetic basis for Cornelia de Lange Syndrome-a developmental disorder that is characterized by slow growth, severe intellectual disability and skeletal abnormalities. He and his group discovered that this syndrome is caused by defects in members of the cohesin-complex and more recently has published a Nature paper uncovering a novel role for HDAC8 in this syndrome. Most recently his lab has shifted focus towards the study of imprinted diseases and chromatin modifiers while maintaining a clinical interest in patients with somatic growth and skeletal disorders.

Host: Kimberly Tremblay

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Seeing how cells feel: interpreting mechanics from microscopic cellular dynamics

Maria Kilfoil Ph.D.
University of Massachusetts, Amherst

Wed, 2/26/2014 - 4:00pm
221 Integrated Sciences Building

Host: Pablo Visconti

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Spontaneous Activation of Rat Oocytes and Generation of Rat Knockout Models

Wei Cui, Ph.D

Tue, 2/25/2014 - 4:00pm
427L Integrated Sciences Building

Dr. Cui has generated novel rat knockouts using the newest Talen technology.

Host: Jesse Mager, Ph.D.

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Role of TGFbeta Superfamily Growth Factors In RegulaSng Beta Cell Expansion and Islet Func

Alan L. Schneyer, Ph.D.
PVLSI and University of Massachusetts

Wed, 2/19/2014 - 4:00pm
221 Integrated Sciences Building

Host: Joseph Jerry

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Life at Tufts Cummings School of Veterinary Medicine from the UMass Alumni Perspective

Jessalyn Chandonnet
Cummings School of Veterinary Medicine

Wed, 11/13/2013 - 4:00pm
221 Integrated Sciences Building

A panel of UMass Alumni who are currently students at or alumni of Tufts Cummings School of Veterinary Medicine will share their perspectives on preparing for veterinary school as an undergraduate as well as how to meet the challenges of vet school. A question and answer period will follow the presentation.

Host: Dr. Janice Telfer, Undergraduate Program Director

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Designing low-cost biosensors for food and agriculture

Dr. Sam Nugen
UMass - Amherst

Wed, 11/6/2013 - 4:00pm
221 Integrated Sciences Building

Host: Dr. Barbara A. Osborne

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Mechanisms of Tumor Initiation and Differentiation

Dr. Vaibhav P. Pai
Tufts University

Wed, 10/30/2013 - 4:00pm
221 Integrated Sciences Building

Host: Dr. Hélène Cousin

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Targeting epigenetic dependencies of tumor initiating cells from triple negative breast cancer therapies

Dr. Fabio Petrocca
Boston Children's Hospital

Wed, 10/23/2013 - 4:00pm
221 Integrated Sciences Building

Host: Dr. D. Joseph Jerry

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Chlamydia; the oncogenic potential of an underestimated STI

Dr. Allen Tsang
Wake Forest School of Medicine

Wed, 10/16/2013 - 4:00pm
221 Integrated Sciences Building

Host: Dr. Kathleen Arcaro

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The denizens of the deep reveal their innermost secrets; a global look at elasmobranch tapeworms

Dr. Janine Caira
UConn

Wed, 10/9/2013 - 4:00pm
221 Integrated Sciences Building

Host: Dr. Samuel Black

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Cannonical and non-cannonical Wnt signalling in Drosophila

Dr. Andreas Jenny
Albert Einstein College

Wed, 10/2/2013 - 4:00pm
221 Integrated Sciences Building

Host: Dr. Kimberly Tremblay

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Finding familar faces in new places; unraveling the mechanisms of immune-mediated bone marrow failure

Dr. Lisa Minter
UMass - Amherst

Wed, 9/25/2013 - 4:00pm
221 Integrated Sciences Building

Host: Ana Maria Salicioni

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"Fox ‘n’ Sox: the Origins of being Neural"

Dr. Sally Moody
The George Washington University

Wed, 5/1/2013 - 4:00pm
221 Integrated Science Building

Host: Dominique Alfandari and Hélène Cousin

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"Genetic and epigenetic insights into making a healthy blastocyst "

Dr. Jason Knott
Michigan State University

Wed, 4/24/2013 - 4:00pm
221 Integrated Science Building

Host: Rafael Fissore

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"Local BLyS production by germinal center TFH cells is required for efficient affinity maturation"

Dr. Radhika Goenka
University of Pennsylvania

Wed, 4/10/2013 - 4:00pm
221 Integrated Science Building

Host: Cynthia Baldwin

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Mechanisms of Tumor Initiation and Differentiation

Dr. Arthur Mercurio
University of Massachusetts-­‐Worcester

Wed, 4/3/2013 - 4:00pm
221 Integrated Science Building

Host: Karen Dunphy

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"Cooperativity of Rb, Brca1, and p53 in Malignant Breast Cancer Evolution"

Dr. Karl Simin
University of Massachusetts-­‐Worcester

Wed, 3/27/2013 - 4:00pm
221 Integrated Science Building

Host: Joe Jerry

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"Morphogenesis of the developing Wolffian/epididymal duct: how do you get 6 meters of epididymis into a human scrotum?"

Dr. Barry Hinton
University of Virginia

Wed, 3/13/2013 - 4:00pm
221 Integrated Science Building

Host: Pablo Visconti

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"The reciprocal role of pituitary SirT1 in growth, reproduction and longevity"

Dr. Michael Bonkowski
Massachusetts Institute of Technology

Wed, 3/6/2013 - 4:00pm
221 Integrated Science Building

Host: Pablo Visconti

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Methanogens: from livestock to humans

Dr. Andre Wright
University of Vermont

Wed, 2/27/2013 - 4:00pm
221 Integrated Science Building

Dr. Wright is an Associate Professor and Chair of the Department of Animal Science. Before coming to the University of Vermont, he was a Research Group Leader at the Australian Government's Commonwealth Scientific and Industrial Research Organization, CSIRO. For the past 12 years, Dr. Wright has been working on developing vaccines and/or other strategies to increase the efficiency of nutrient utilization in livestock, and to reduce their enteric methane emissions. His research has made significant contributions in the area of molecular microbiology, resulting in novel options being developed to reduce methane emissions from livestock. Consequently, Dr. Wright's research also suggests that the manipulation of the rumen microorganisms may increase methane production in anaerobic digestors as some methane-producing microorganisms may be more efficient and potent than others.

Host: Susan Leschine

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"The importance of super-enhancers in transcriptional regulation during development and disease"

Dr. Warren Whyte
Whitehead Medical Institute

Wed, 2/20/2013 - 4:00pm
221 Integrated Science Building

Transcription factors bind enhancer elements and recruit chromatin regulators to activate genes in cells. We report here that certain key transcription factors and the chromatin regulator Mediator form “super-enhancers” at key cell identity genes in mammalian cells. These super-enhancers consist of extraordinarily large genomic domains occupied by exceptional amounts of transcription factors and chromatin regulators. Reduced levels of these regulatory proteins cause preferential loss of expression of super-enhancer -associated genes relative to other genes, implicating super-enhancers in the control of mammalian cell identity and development.

In cancer, chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. We also report that inhibition of the widely-expressed chromatin regulator BRD4 leads to selective inhibition of the MYC oncogene in multiple myeloma (MM). BRD4 and Mediator were found to co- occupy a small set of super-enhancers associated with genes that feature prominently in MM biology, including the MYC oncogene. Treatment of tumor cells with the Brd4 inhibitor JQ1 led to preferential loss of BRD4 at super-enhancers and consequent transcription elongation defects that preferentially impacted genes with super-enhancers, including the MYC oncogene. Super- enhancers were found at key oncogenic drivers in many other tumor cells. These observations have implications for the discovery of novel cancer therapeutics directed at components of super-enhancers in diverse tumor types.

Host: Barbara Osborne and Richard Goldsby

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"Negative regulation of the tumor suppressor protein p53 by deficiency of oxidative phosphorylation"

Dr. Nayendra Yadava
Pioneer Valley Life Science Institute

Wed, 2/13/2013 - 4:00pm
221 Integrated Sciences Building

Overview: Mitochondrial function is one of the most fundamental of cellular functions. Impaired mitochondrial function results in a host of diseases with nerves and muscle being among the tissues most sensitive. While inherited severe impairment of mitochondrial respiration is infrequent, a decline in mitochondrial function is observed with aging and obesity. Many environmental chemicals are also toxic to mitochondrial enzymes. Dr. Yadava's recent work has demonstrated that impairment of mitochondria disrupts tumor suppressor pathways suggesting that this may be a common basis for age-associated increases in the incidence of cancer.

Find more information at: Impaired Mitochondrial Metabolism and Mammary Carcinogenesis.

Yadava N, Schneider SS, Jerry DJ, Kim C.J Mammary Gland Biol Neoplasia. 2012 Dec 27. [Epub ahead of print] PMID: 23269521
Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. Compton S, Kim C, Griner NB, Potluri P, Scheffler IE, Sen S, Jerry DJ, Schneider S, Yadava N. J Biol Chem. 2011 Jun 10;286(23):20297-312. doi: 10.1074/jbc.M110.163063. Epub 2011 Apr 18. PMID:21502317
Quantitative microplate-based respirometry with correction for oxygen diffusion. Gerencser AA, Neilson A, Choi SW, Edman U, Yadava N, Oh RJ, Ferrick DA, Nicholls DG, Brand MD. Anal Chem. 2009 Aug 15;81(16):6868-78. doi: 10.1021/ac900881z. PMID: 19555051
Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria.Chinta SJ, Rane A, Yadava N, Andersen JK, Nicholls DG, Polster BM. Free Radic Biol Med. 2009 Apr 1;46(7):939-47. PMID 19280713
Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Amo T, Yadava N, Oh R, Nicholls DG, Brand MD. Gene. 2008 Mar 31;411(1-2):69-76. doi: 10.1016/j.gene.2008.01.007. Epub 2008 Jan 26. PMID: 18280061
Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly. Yadava N, Potluri P, Scheffler IE. Int J Biochem Cell Biol. 2008;40(3):447-60. Epub 2007 Sep 6. PMID: 17931954
Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. Yadava N, Nicholls DG. J Neurosci. 2007 Jul 4;27(27):7310-7. PMID: 17611283
Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity. Nicholls DG, Johnson-Cadwell L, Vesce S, Jekabsons M, Yadava N. J Neurosci Res. 2007 Nov 15;85(15):3206-12. Review. PMID: 17455297

Host: Joe Jerry

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“New insights into liver organogenesis- the role of Hhex in hepatic specification and bile duct formation”

Dr. Clifford Bogue
Yale University

Wed, 12/5/2012 - 4:00pm
221 Integrated Science Building

Host: Dr. Kimberly Tremblay

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“Parthenogenesis in insects”

Dr. Benjamin Normark
UMass Amherst, PSIS Dept

Wed, 11/7/2012 - 4:00pm
221 Integrated Science Building

Host: Dr. Rafael Fissore

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“Tracking Nanoparticles in Biological and Environmental Systems”

Dr. Richard Vachet
UMass Amherst, Chemistry Dept

Wed, 10/24/2012 - 4:00pm
221 Integrated Science Building

Host: Dr. D. Joseph Jerry

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“Chemical Biotechnology Applied to Endocrine Hormones”

Dr. Richard DiMarchi
Indiana University Bloomington

Wed, 10/17/2012 - 4:00pm
221 Integrated Science Building

Host: Dr. Kimberly Tremblay (VASCI) and Dr. Min Chen (Chemistry)

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“Microbes that link biomass to energy and food to health”

Dr. Susan Leschine
UMass Amherst

Wed, 10/10/2012 - 4:00pm
221 Integrated Science Building

Host: Dr. Hélène Cousin

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“From studies of the molecular and cell biology of ‘Shipping Fever” to the creation of a biotechnology for its management”

Dr. S. Srikumaran
Washington State University

Wed, 10/3/2012 - 4:00pm
221 Integrated Science Building

Host: Dr. Barbara Osborne and Dr. Richard Goldsby

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"LAFMO controls: Don't let your FACS analysis be a one hit wonder. Party Rock your data analysis and compensation controls"

Dr. Amy Burnside
UMass Amherst

Wed, 9/19/2012 - 4:00pm
221 Integrated Science Building

Host: Dr. Lisa Minter

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“Nanoparticles as Cancer Diagnostics and Therapeutics.”

Vincent Rotello
UMass Amherst, Chemistry Dpt

Wed, 4/25/2012 - 4:00pm
221 Integrated Science Building

Host: Joseph Jerry

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“A Billion Years of NF-kB: Sea Anemones to Lymphoma.”

Thomas Gilmore
Boston University

Wed, 4/18/2012 - 4:00pm
221 Integrated Science Building

Host: Sandra Petersen

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“Galapagos finches and the unfinished business of Charles Darwin.”

Jeffrey Podos
UMass Amherst, Biology Dpt

Wed, 4/11/2012 - 4:00pm
221 Integrated Science Building

Host: Pablo Visconti

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“The Multilayered Epigenetics of the Mammalian X Chromosome.”

Michael O’Neill
University of Connecticut

Wed, 4/4/2012 - 4:00pm
221 Integrated Science Building

Host: Pablo Visconti

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“iPSC models of chromosome 15q11-q13 imprinting disorders”

Stormy Chamberlain
University of Connecticut

Wed, 3/28/2012 - 4:00pm
221 Integrated Science Building

Host: Jesse Mager

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“Toward the Origin of Craniofacial Diversity in Cichlid Fishes: Patterns, Processes and Mechanisms.”

Craig Albertson
UMass Amherst, Biology Dpt

Wed, 3/14/2012 - 4:00pm
221 Integrated Science Building

Host: Hélène Cousin

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"The essential functions of D-cyclins in stem cell survival and tumor maintenance."

Yoon Choi
Dana Farber Cancer Inst., Harvard Med. School

Wed, 3/7/2012 - 4:00pm
221 Integrated Science Building

Host: Barbara Osborne

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“Genetic Approaches in Mouse to Interrogate Brain Development and Disease”

Mark Zervas
Brown University

Wed, 2/22/2012 - 4:00pm
221 Integrated Science Building

Host: Kimberly Tremblay

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“Top Down genomics: generating testable mechanistic hypotheses from Genome wide studies.”

Aaron Mackey
University of Virginia

Wed, 2/1/2012 - 4:00pm
221 Integrated Science Building

Host: Joseph Jerry

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Notch signaling during embryonic development in mice

Tom Gridley
Maine Medical Center Research Institute

Wed, 12/7/2011 - 4:00pm
221 Integrated Science Building

Host: Barbara Osborne

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From epigenetic to genetic risk-variants: Defining FoxA1 genomic activity in breast and prostate cancer

Mathieu Lupien
Norris Cotton Cancer Ctr., Dartmouth College

Wed, 11/30/2011 - 4:00pm
221 Integrated Science Building

Host: Joe Jerry

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Mechanisms of fertilization in the mouse

Keith Sutton
UMass Worcester, Biology Department

Wed, 11/9/2011 - 4:00pm
221 Integrated Science Building

Host: Rafael Fissore

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Differential AHR Signaling Mediates Obesity Levels in Mice Fed a Western Diet

Craig Tomlinson
Norris Cotton Cancer Ctr, Dartmouth College

Wed, 11/2/2011 - 4:00pm
221 Integrated Science Building

Host: Joe Jerry

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Dopamine and neuron activity in the nematode C. elegans

Dan Chase
UMass Amherst, Biochemistry Department

Wed, 10/26/2011 - 4:00pm
221 Integrated Science Building

Host: Pablo Visconti

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Regulating mitosis by histone phosphorylation

Jonathan Higgins
Harvard Medical School

Wed, 10/19/2011 - 4:00pm
221 Integrated Science Building

Host: Pablo Visconti

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A Tense Relationship: Regulation of chromosome-microtubule interactions by mitotic forces

Tom Maresca
UMass Amherst, Biology Department

Wed, 10/12/2011 - 4:00pm
221 Integrated Science Building

Host: Pablo Visconti

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Identification and Mechanism of Regulation of the Zebrafish Dorsal Determinant

Bernard Thisse
University of Virginia

Wed, 9/28/2011 - 4:00pm
221 Integrated Science Building

Host: Hélène Cousin

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Neuron differentiation during mouse brain development

Paola Arlotta
Harvard Medical School

Wed, 9/21/2011 - 4:00pm
221 Integrated Science Building

Host: Dominique Alfandari

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MCB Seminar

Wed, 4/27/2011 - 4:00pm

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TBA

Art Mercurio
UMass Medical School

Wed, 4/13/2011 - 4:00pm
221 Integrated Science Building

Host: Karen Dunphy

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TBA

Archibald Perkins
Univ. of Rochester Medical School

Wed, 4/6/2011 - 4:00pm
221 Integrated Science Building

Host: Lisa Minter

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Role of Host-parasite interactions during the establishment of blood fluke infections

Stephen Davies
Uniform Services, Univ. of Health Sciences

Wed, 3/30/2011 - 4:00pm
221 Integrated Science Building

Host: Sam Black

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TBA

Frances Carr
UVM

Wed, 3/23/2011 - 4:00pm
221 Integrated Science Building

Host: Kate Fagen-Solis

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Notch regulation of progenitor cell fate in the lung

Wellington Cardosa
Boston University

Wed, 3/9/2011 - 4:00pm
221 Integrated Science Building

Host: Kim Tremblay

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TBA

Pam Schwartzber

Fri, 3/4/2011 - 4:00pm
221 Integrated Science Building

Host: Barbara Osborne

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TBA

Alberto Darszon

Wed, 2/23/2011 - 4:00pm
221 Integrated Science Building

Host: Pablo Visconti

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To Cut or Not to Cut: Regulating the Location of Mocrotubule Severing Enzyme Activity

Jennifer Ross
Dept. of Physics, UMass Amherst

Wed, 2/16/2011 - 4:00pm
221 Integrated Science Building

Host: Lisa Minter

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Building a small molecule tool box for biomedical research: Probe development opportunities through the NIH's MLPC

Nicola Tolliday, Broad Institute

Wed, 2/9/2011 at 4:00pm
221 Integrated Science Building

Host: Barbara Osborne

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Exploring the Developmental Oncobiology of Breast Cancer using Mouse Models

Zhe Li

Harvard Medical School

Wed, 2/2/2011 at 4:00pm
221 Integrated Science Building

Host: Joe Jerry