Mark S. Miller

Assistant Professor
106 Totman Building
413-577-4701
markmiller@kin.umass.edu

Education: 

B.S., University of Colorado; M.S., University of Colorado; Ph.D., University of Vermont; Post-Doctoral Fellowship, University of Vermont

Area(s) of Specialization: 

Aging, Exercise, Skeletal Muscle, Muscle Mechanics, Sex Differences

Research Description: 

My primary interest is investigating the effects of aging and exercise on human skeletal muscle in males and females at the whole body, tissue, single fiber and molecular levels. The goal is to understand how alterations at the molecular and single fiber levels affect whole muscle contraction in order to find potential sex-specific countermeasures to prevent the age-related loss of muscle performance. The laboratory combines the use of advanced engineering methods to measure muscle function at the molecular and single fiber levels with imaging techniques to examine muscle structure from the myofibril to the tissue level, biochemical techniques to quantify proteins as well as techniques to analyze the whole body skeletal muscle contractile performance.

Key Publications: 

Straight CR, Toth MJ, Miller MS. Current perspectives on obesity and skeletal muscle contractile function in older adults. Journal of Applied Physiology 130(1), 10-16, 2021. PMCID: In Progress

Straight CR, Ringham OR, Bartley JM, Keilich SR, Kuchel GA, Haynes L, Miller MS. Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice. Journal of Gerontology, Biological Sciences 75(12), 2333-2341, 2020. PMCID: PMC7750940

Straight CR, Fedewa MV, Toth MJ, Miller MS. Improvements in skeletal muscle fiber size with resistance training are age-dependent in older adults: a systematic review and meta-analysis. Journal of Applied Physiology 129(2), 392-403, 2020. PMCID: PMC7473942

Phung LA, Foster AD, Miller MS, Lowe DA, Thomas DD. Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent. American Journal of Physiology-Cell Physiology 319(6), C1158-C1162, 2020. PMCID: In Progress

Palmer BM, Swank DM, Miller MS, Tanner BCW, Meyer M, LeWinter MM. Enhancing diastolic function by strain-dependent detachment of cardiac myosin crossbridges. Journal of General Physiology 152(4), e201912484, 2020. PMCID: PMC7141588