B.S. Université Montpellier I, Montpellier (France), 2002; M.S. Université Montpellier I, Montpellier (France), 2004; PhD. Université de la Mediteranée, Marseille (France), 2008; Postdoctoral fellow. University of Utah, Salt Lake City, 2013
Area(s) of Specialization:
Musculoskeletal Physiology, Bioenergetics, Mitochondria, Cardiovascular Physiology, Magnetic Resonance Spectroscopy/imaging
My current research goals are to:
- Better understand the role of oxidative stress and physical inactivity in mediating peripheral abnormalities in O2 transport and muscle bioenergetics associated with aging and disease (e.g. Chronic Obstructive Pulmonary Disease, Peripheral Arterial Disease, heart failure),
- Explore pharmacologic, nutritional or exercise-based strategies that can mitigate the deleterious vascular and metabolic dysfunction associated with these conditions.
To achieve these goals, I employ an integrative approach from the cellular level to the whole organism in humans, which encompasses ultrasound Doppler, magnetic resonance spectroscopy (31P/1H)and imaging, motor nerve stimulation, high resolution respirometry, electron paramagnetic resonance spectroscopy, and a host of molecular and cellular biology techniques.
Layec, G.; Bringard, A.; Le Fur, Y.; Vilmen, C.; Micallef, J.P.; Perrey, S.; Cozzone, P.J.; Bendahan, D. Comparative determination of energy production rates and mitochondrial function using different 31P MRS quantitative methods in sedentary and trained subjects. NMR in biomedicine. 24:425-438; 2011a
Layec, G.; Hart, C.R.; Trinity, J.D.; Le Fur, Y.; Jeong, E.K.; Richardson, R.S. Skeletal muscle work efficiency with age: the role of non-contractile processes. Clin Sci (Lond). 128:213-223; 2015
Layec, G.; Haseler, L.J.; Hoff, J.; Richardson, R.S. Evidence that a higher ATP cost of muscular contraction contributes to the lower mechanical efficiency associated with COPD: preliminary findings. American journal of physiology. 300:R1142-1147; 2011b
Layec, G.; Haseler, L.J.; Trinity, J.D.; Hart, C.R.; Liu, X.; Le Fur, Y.; Jeong, E.K.; Richardson, R.S. Mitochondrial function and increased convective O2 transport: implications for the assessment of mitochondrial respiration in vivo. J Appl Physiol (1985). 115:803-811; 2013
Layec, G.; Trinity, J.D.; Hart, C.R.; Le Fur, Y.; Zhao, J.; Reese, V.; Jeong, E.K.; Richardson, R.S. Impaired muscle efficiency but preserved peripheral hemodynamics and mitochondrial function with advancing age: Evidence from exercise in the young, old, and oldest-old. The journals of gerontology; 2018