B.S., Cornell University, 2003; Ph.D., Tufts University School of Medicine, 2007; Postdoctoral Fellow & Research Associate, The Forsyth Institute Center for Regenerative & Developmental Biology and Harvard University School of Dental Medicine, 2007-2008; Postdoctoral Fellow, Tufts University, Department of Biology and Center for Regenerative & Developmental Biology, 2008-2013
Area(s) of Specialization:
endocrine disruptors, hazard assessment, developmental biology, endocrinology
My research explores how early life exposures to chemicals and chemical mixtures can predispose individuals to diseases that manifest later in life. Classical toxicology often focuses on how fetal chemical exposures can produce birth defects, an important part of chemical safety. My work instead addresses how low doses of chemicals during critical windows of development can alter gene expression, cell differentiation, and tissue organization in subtle ways that can lead to adult diseases such as cancer, obesity, and infertility. I am specifically interested in the class of chemicals termed ‘endocrine disruptors’ and have worked extensively with chemicals used as plasticizers and flame retardants. My work also focuses on how traditional toxicology assays have failed to identify a number of ubiquitous endocrine disruptors, and how current risk assessment practices can be improved in the study and regulation of this class of chemicals.
Kolla S, McSweeney DB, Pokharel A, Vandenberg LN. 2019. Bisphenol S alters development of the male mouse mammary gland and sensitizes it to a pubertal estrogen challenge. Toxicology. 424: 152234.
Porta M, Vandenberg LN. 2019. There are good clinical, scientific, and social reasons to strengthen links between biomedical and environmental research. Journal of Clinical Epidemiology. 111: 124-126.
Vandenberg LN, Hunt PA, Gore AC. 2019. Endocrine disruptors and the future of toxicity testing: lessons from CLARITY-BPA. Nature Reviews Endocrinology. 15(6): 366-374.
Pokharel A, Kolla S, Matouskova K, Vandenberg LN. 2018. Asymmetric development of the male mouse mammary gland and its sensitivity to a prenatal or postnatal estrogen challenge. Reproductive Toxicology. 82: 63-71.
LaPlante CD, Bansal R, Dunphy KA, Jerry DJ, Vandenberg LN. 2018. Oxybenzone alters mammary gland morphology in mice exposed during pregnancy and lactation. Journal of the Endocrine Society. 2(8): 903-921.