B.M., University of Massachusetts Amherst; M.P.H., University of Massachusetts Amherst; Ph.D., University of Massachusetts Amherst; Postdoctoral Fellow, Massachusetts General Hospital; IRTA Postdoctoral Fellow/Research Fellow, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Area(s) of Specialization:
Air pollution, reproductive health, perinatal epidemiology
As an environmental and reproductive epidemiologist my work focuses on the impact of exposure to ambient air pollution during preconception and in early pregnancy on reproductive and perinatal health. A strong evidence base suggests that air pollution, likely through mechanisms of inflammation, oxidative stress and vascular dysfunction, increases risk of cardiovascular events and pregnancy complications. My research centers on understanding how these mechanisms may similarly impact reproductive health during critical windows of exposure including ovulation, spermatogenesis, implantation and vascularization of the placenta. The main goal of my research is to produce policy-relevant findings for the impact of both acute and chronic exposure to ambient air pollution on maternal, paternal and offspring health.
Nobles CJ, Williams A, Ouidir M, Sherman S, Mendola P. Differential Effect of Ambient Air Pollution Exposure on Risk of Gestational Hypertension and Preeclampsia. Hypertension. 2019;74(2):384-390.
Nobles CJ, Grantz KL, Liu D, Williams A, Ouidir M, Seeni I, Sherman S, Mendola P. Ambient air pollution and fetal growth restriction: Physician diagnosis of fetal growth restriction versus population-based small-for-gestational age. Sci Total Environ. 2019;650(Pt 2):2641-2647.
Nobles CJ, Mendola P, Mumford SL, Naimi AI, Yeung EH, Kim K, Park H, Wilcox B, Silver RM, Perkins NJ, Sjaarda L, Schisterman EF. Preconception Blood Pressure Levels and Reproductive Outcomes in a Prospective Cohort of Women Attempting Pregnancy. Hypertension; 2018;71(5):904-910.
Nobles CJ, Schisterman EF, Ha S, Kim K, Mumford SL, Buck Louis GM, Chen Z, Liu D, Sherman S, Mendola P. Ambient air pollution and semen quality. Environ Res. 2018;163:228-236.
Nobles CJ, Schisterman EF, Ha S, Buck Louis GM, Sherman S, Mendola P. Time-varying cycle average and daily variation in ambient air pollution and fecundability. Hum Reprod. 2018;33(1):166-176.