Biostatistics Seminar Series: Christina Leslie, PhD

Biostats Seminar speaker Christina Leslie

Friday, October 9, 2020 - 10:00am

Location: Online

Join us online as the Department of Biostatistics and Epidemiology welcomes Dr. Christina Leslie from Memorial Sloan Kettering Cancer Center's Computational and Systems Biology Program. Leslie will deliver a talk titled "Decoding chromatin states and gene regulation" on Friday, October 9th, beginning at 10:00 AM via Zoom.

Talk abstract: We will describe our work in regulatory genomics and 3D genomic architecture to computationally dissect changes in chromatin state and gene expression in cellular differentiation.  First we will describe a large-scale study encompassing both published bulk data as well as new single cell studies to understand T cell differentiation towards dysfunction (“exhaustion”) in tumors and in chronic infection.  We will then highlight progress on the statistical analysis of 3D interaction data, like Hi-C and HiChIP, and predictive models of gene regulation that incorporate 3D architecture.

Email Tonya Menard to pre-register and receive the Zoom link.