Dr. Edward J. Calabrese
Dr. Calabrese studies host factors affecting susceptibility to pollutants, and aims to understand the nature of dose and response in the low dose zone and underlying adaptive explanatory mechanisms. Much of this work focuses on discoveries in expanding understanding of the hormetic-biphasic dose response relationship. These observations are leading to refinement of scientific foundations for risk assessment and environmental regulation for radiation and chemicals.
Dr. J. Richard Pilsner
Dr. Pilsner’s laboratory investigates how environmental and nutritional factors influence health outcomes via epigenetic processes using both epidemiological and experimental approaches. More recently, Dr. Pilsner has focused on understanding how paternal exposure to endocrine disrupting compounds affects reproductive and offspring health – in both embryonic and placental tissue. Specifically, his work examines phthalate exposure across a diverse set of reproductive outcomes, including male reproductive health, birth outcomes, and offspring neurodevelopment.
Dr. Alexander Suvorov
Dr. Suvorov’s research focuses on understanding the molecular mechanisms that participate in life-long programming of mammalian tissues following developmental exposures to environmental xenobiotics. In particular, he is interested in long-term reprogramming of metabolic, reproductive and neuro-behavioral functions, the role of the mTOR pathway in this reprograming and epigenetic mechanisms underlying long- lasting maintenance of tissues’ malfunctioning. Dr. Suvorov uses a variety of approaches including animal and in vitro models and state of the art genomic and epigenetic methods which capitalize on recent advances in high throughput sequencing.
Dr. Alicia R. Timme-Laragy
Using the zebrafish (Danio rerio) as a model system, Dr. Timme-Laragy’s research aims to elucidate cellular and molecular mechanisms of toxicant-induced oxidative stress in embryonic development, and identify later-life consequences of embryonic exposure to oxidative stress. Of particular interest is to understand how transcription factors, such as Ahr and Nrf2, play a role in the ontogeny and adaptive response of antioxidant defenses during embryonic development.
Dr. Laura N. Vandenberg
Dr. Vandenberg’s research explores how early life exposures to chemicals and chemical mixtures can predispose individuals to diseases that manifest later in life. Her work addresses how low doses of chemicals during critical windows of development can alter gene expression, cell differentiation, and tissue organization in subtle ways that can lead to adult diseases such as cancer, obesity, and infertility. She is specifically interested in endocrine disruptors and has worked extensively with chemicals used as plasticizers and flame retardants. Her work also focuses on how traditional toxicology assays have failed to identify a number of ubiquitous endocrine disruptors, and how current risk assessment practices can be improved in the study and regulation of this class of chemicals.