Optically-responsive Quantum-dot-based Biosensors for Rapid Detection and Quantitation of Bioanalytes
This platform technology employs a new class of nanoscale fluorescent biosensors with rapid and quantifiable responses to the binding of target bioanalytes. Each biosensor consists of a semiconductor nanocrystal (quantum dot) tethered to a biomolecular probe via a stabilizing linker. The binding of the biomolecular probe to its intended target bioanalyte causes a change in the fluorescence emission intensity of the quantum dot, enabling instantaneous sensing of the presence of the bioanalyte. Quantitative analysis of the bioanalyte can be readily performed by using simple dose-response assays.
- Point-of-care medical diagnostics
- High-throughput screening of biomolecules for drug discovery and development
- Rapid testing of biological threats for public safety and military applications
- Instantaneous detection of probe-target interactions such as antibody-antigen, DNA-DNA, DNA-RNA, nucleic acid-protein, protein-sugar interactions
- Rapid quantitative analysis of bioanalytes such as disease associated biomarkers and pathogens
- High detection sensitivity and multiplexing capability
- High nucleic acid detection selectivity enabling discrimination of single-base mismatches
Ling X. Shen, Ph.D., M.B.A.
Commercial Ventures and Intellectual Property