Perry Research Group


Research Articles (top)

  1. I. Ramírez Marrero, L. Boudreau, R. Gutzler, N. Kaiser, B. von Vacano, R. Konradi, S.L. Perry, "Decoupling the Effects of Charge Density and Hydrophobicity on the Phase Behavior and Viscoelasticity of Complex Coacervates," Macromolecules, (2024), 57(10), 4680-4694. [PDF]
  2. A. Sathyavageeswaran, J. Bonesso Sabadini, S.L. Perry, "Self-Assembling Polypeptides in Complex Coacervation," Accounts of Chemical Research, (2024), 57(3), 386-398. [PDF]
  3. P.U. Joshi, C. Decker, X. Zeng, A. Sathyavageeswaran, S.L. Perry, C.L. Heldt, "Design Rules for the Sequestration of Viruses into Polypeptide Complex Coacervates," Biomacromolecules, (2024), 25(2), 741-753. [PDF]
  4. S.L. Perry, "Ensembles of Synthetic Polymers Mimic Biological Fluids," Trends in Biochemical Sciences, (2023) 48(9), 746-747 (Spotlight article). [PDF]
  5. J. Madinya, H. Tjo, X. Meng, I.A. Ramírez Marrero, C.E. Sing, S.L. Perry, "Surface Charge Density and Steric Repulsion in Polyelectrolyte-Surfactant Coacervation," Macromolecules, (2023), 56(11), 3973-3988. [PDF]
  6. S. Saha, C. Özden, A. Samkutty, S. Russi, A. Cohen, M.M. Stratton, S.L. Perry, "Polymer-based Microfluidic Device for On-chip Counter-diffusive Crystallization and In Situ X-ray Crystallography at Room Temperature," Lab on a Chip, (2023), 23, 2075-2090. [PDF]
  7. J. Liu, S.L. Perry, B.Z. Tang, M.V. Tirrell, "Liquid Capsules for Gastrointestinal Drug Delivery," Matter, (2022), 5, 3107-3019 (Preview article). [PDF]
  8. A.R. Johnston, E.D. Minckler, M.C.J. Shockley, L.N. Matsushima, S.L. Perry, A.L. Ayzner, "Conjugated Polyelectrolyte-Based Complex Fluids as Aqueous Exciton Transport Networks," Angewandte Chemie International Edition, (2022), 61(20), e202117759. [PDF]
  9. J. Sun, J.D. Schiffman, S.L. Perry, "Linear Viscoelasticity and Time–Alcohol Superposition of Chitosan/Hyaluronic Acid Complex Coacervates," ACS Applied Polymer Materials, (2022), 4(3), 1617-1625. [PDF]
  10. M. Lee, S.L. Perry, R.C. Hayward, "Complex Coacervation of Polymerized Ionic Liquids in Non-Aqueous Solvents," ACS Polymers Au, (2021), 1(2), 100–106. [PDF]
  11. X. Meng, Y. Du, Y. Liu, E.B. Coughlin, S.L. Perry, J.D. Schiffman, "Electrospinning Fibers from Oligomeric Complex Coacervates: No Chain Entanglements Needed," Macromolecules, (2021), 54, 5033-5042. [PDF]
  12. S. Sui, A. Mulichak, R. Kulathila, J. McGee,‡ D. Filiatreault, S. Saha, A. Cohen, J. Song, H. Hung, J. Selway, C. Kirby, O.K. Shrestha, W. Weihofen, M. Fodor, M. Xu, R. Chopra, S.L. Perry, "A Capillary-based Microfluidic Device Enables Primary High-throughput Room-temperature Crystallographic Screening," Journal of Applied Crystallography, (2021), 54(4), 1034-1046. [PDF]
  13. A.R. Johnston, S.L. Perry, A.L. Ayzner, "Associative Phase Separation of Aqueous π-Conjugated Polyelectrolytes Couples Photophysical and Mechanical Properties," Chemistry of Materials, (2021) 33(4), 1116-1129. [PDF]
  14. W.C. Blocher McTigue, S.L. Perry, "Incorporation of Proteins into Complex Coacervates," Methods in Enzymology, (2021) 646, 277-306. [PDF]
  15. R. Otten, R.A.P. Pádua, H.A. Bunzel, V. Nguyen, W. Pitsawong, M. Patterson, S. Sui, S.L. Perry, A. Cohen, D. Hilvert, D. Kern, "How Directed Evolution Reshapes Energy Landscapes to Boost Catalysis," Science, (2020), 370(6523), 1442-1446. [PDF]
  16. X. Mi, W.C. Blocher McTigue, P.U. Joshi, M.K. Bunker, C.L. Heldt, S.L. Perry, "Thermostabilization of Viruses via Complex Coacervation," Biomaterials Science, (2020), 8, 7082-7092. [PDF]
  17. Highlighted in the Biomaterials Science themed collection on Emerging Investigators.
    Highlighted in the 2020 Biomaterials Science Most Popular themed collection.

  18. Y. Liu, C.F. Santa Chalarca, R.N. Carmean, R.A. Olson, J. Madinya, B.S. Sumerlin, C.E. Sing, T. Emrick, S.L. Perry, "Effect of Polymer Chemistry on the Linear Viscoelasticity of Polyelectrolyte Complexes," Macromolecules, (2020), 53(18), 7851-7864. [PDF]
  19. W.C. Blocher McTigue, E. Voke, L.W. Chang, S.L. Perry, "The Benefit of Poor Mixing: Kinetics of Coacervation," Physical Chemistry Chemical Physics, (2020) 22, 20643-20657. [PDF]
  20. H.S. Azevedo, S.L. Perry, P.A. Korevaar, D. Das, "Complexity Emerges from Chemistry," Nature Chemistry, 2020, 12, 793-794, (invited meeting report). [PDF]
  21. W.C. Blocher McTigue, S.L. Perry, "Protein Encapsulation using Complex Coacervates: What Nature has to Teach Us," Small, (2020), 16(27), 1907671. [PDF]
  22. C.E. Sing, S.L. Perry, "Recent Progress in the Science of Complex Coacervation," Soft Matter, (2020), 16, 2885-2914. [PDF]
  23. Highlighted in the 2020 Soft Matter Most Popular themed collection.

  24. S.L. Perry, D.J. McClements, "Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems," Molecules, (2020), 25(5), 1161. [PDF]
  25. S.L. Perry, C.E. Sing, "100th Anniversary of Macromolecular Science Viewpoint: Opportunities in the Physics of Sequence-Defined Polymers," ACS Macro Letters, (2020), 9, 216-225. [PDF]
  26. J. Zhuang, B. Zhao, X. Meng, J.D. Schiffman, S.L. Perry, R. Vachet, S. Thayumanavan, "Programmable Chemical Switch based on Triggerable Michael Acceptors," Chemical Science, (2020), 11, 2103-2111. [PDF]
  27. J. Madinya, L.W. Chang, S.L. Perry, C.E. Sing, "Sequence-Dependent Self-Coacervation in High Charge-Density Polyampholytes," Mol. Syst. Des. Eng., (2020), 5, 632-644. [PDF]
  28. J. Sun, S.L. Perry, J.D. Schiffman, "Electrospinning Nanofibers from Chitosan/Hyaluronic Acid Complex Coacervates," Biomacromolecules, (2019), 20(11), 4191-4198. [PDF]
  29. I.S. Kurtz, S. Sui, X. Hao, M. Huang, S.L. Perry, J.D. Schiffman, "Bacteria-resistant, Transparent, Free-standing Films Prepared from Complex Coacervates," ACS Applied Bio Materials, (2019), 2, 3926-3933. [PDF]
  30. T.K. Lytle, L.W. Chang, N. Markiewicz, S.L. Perry, C.E. Sing, "Designing Electrostatic Interactions via Polyelectrolyte Monomer Sequence," ACS Central Science, (2019), 5, 709-718. [PDF]
  31. Highlighted in the UMass Amherst News: UMass Amherst Chemical Engineer Sarah L. Perry Helps Decode How Charge Patterns Instruct Polymer Chain Functions

  32. W.C. Blocher McTigue, S.L. Perry, "Design Rules for Encapsulating Proteins into Complex Coacervates," Soft Matter, (2019), 15, 3089-3103. [PDF]
  33. Correction: Soft Matter, (2019), 15, 8412-8412. [PDF]

    Highlighted in the Soft Matter themed collection on Emerging Investigators.

  34. S.L. Perry, "Phase Separation: Bridging Polymer Physics and Biology," Current Opinion in Colloid and Interface Science, (2019), 39, 86-97. [PDF]
  35. X. Meng, J.D. Schiffman, S.L. Perry, "Electrospinning Cargo-Containing Polyelectrolyte Complex Fibers: Correlating Molecular Interactions to Complex Coacervate Phase Behavior and Fiber Formation," Macromolecules, (2018), 51, 8821-8832. [PDF]
  36. S.L. Perry, D.A. Hoagland, "Obituary for Prof. Paul Dubin," Soft Matter, (2018), 14, 8083-8084. [PDF]
  37. M. Skinner, B.M. Johnston, Y. Liu, R. Selhorst, I. Xenidou, S.L. Perry, T. Emrick, "Synthesis of Zwitterionic Pluronic Mimics," Biomacromolecules, (2018), 19(8), 3377-3389. [PDF]
  38. P.M. McCall, S. Srivastava, S.L. Perry, D.R. Kovar, M.L. Gardel, M.V. Tirrell, "Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates," Biophysical Journal, (2018), 114(7), 1636-1645. [PDF]
  39. Featured on the journal cover. Highlighted on the Biophysical Society Blog.

  40. S. Sui, Y. Wang, C. Dimitrakopoulos, S.L. Perry, "A Graphene-based Microfluidic Platform for Electro-crystallization and In Situ X-ray Diffraction," Crystals, (2018), 8(2), 76. [PDF]
  41. L.W. Chang, T.K. Lytle, M. Radhakrishna, J.J. Madinya, J. Vélez, C.E. Sing, S.L. Perry, "Sequence and Entropy-Based Control of Complex Coacervates," Nature Communications, (2017), 8, 1273. [PDF]
  42. Highlighted in the UMass Amherst News: "UMass Amherst Researcher Makes New Bioinspired Polymers Using Electrostatic Force"
    Highlighted in the University of Illinois News: "Electrostatic force takes charge in bioinspired polymers"
    Highlighted in Nanotechnology Now: "Electrostatic force takes charge in bioinspired polymers"
    Highlighted in Electronics 360: "Bioinspired Polymers Get Their Charge From Electrostatic Force"
    Highlighted by Nanowerk: "Electrostatic force takes charge in bioinspired polymers"
    Highlighted by My Science: "Electrostatic force takes charge in bioinspired polymers"
    Highlighted by Science Newsline: "Electrostatic force takes charge in bioinspired polymers"
    Highlighted by R&D: "Electrostatic force takes charge in bioinspired polymers"
    Highlighted by EurekAlert!: "Electrostatic force takes charge in bioinspired polymers"
    Highlighted by AZO Materials: "Progress Towards Controlling Self-Assembly of Artificial Materialss"
    Highlighted by "Electrostatic force takes charge in bioinspired polymers"
    Highlighted by "UMass Engineer Makes Bioinspired Polymers with Electrostatic Force"

  43. Y. Liu, B. Momani, H.H. Winter, S.L. Perry, "Rheological Characterization of Liquid-to-Solid Transitions in Bulk Polyelectrolyte Complexes," Soft Matter, (2017), 13, 7332-7340. [PDF]
  44. B.M. Johnston, C. W. Johnston, R. A. Letteri, T.K. Lytle, C.E. Sing, T. Emrick, S.L. Perry, "The Effect of Comb Architecture on Complex Coacervation," Organic and Biomolecular Chemistry, (2017), 15, 7630-7642. [PDF]
  45. Highlighted in the Organic & Biomolecular Chemistry Blog

  46. W.C. Blocher, S.L. Perry, "Biomimetic Complex Coacervate-Based Materials for Biomedicine," WIREs Nanomedicine and Nanobiotechnology, (2017), 9(4), e1442. [PDF]
  47. X. Meng, S.L. Perry, J.D. Schiffman, "Complex Coacervation: Chemically Stable Fibers Electrospun from Aqueous Polyelectrolyte Solutions," ACS Macro Letters, (2017), 6, 505-511. [PDF]
  48. Highlighted in: Data from University of Massachusetts Advance Knowledge in Tissue Engineering, Biotech Week, June 28th, 2017.

  49. M. Radhakrishna, K. Basu, Y. Liu, R. Shamsi, S.L. Perry, C.E. Sing, "Molecular Connectivity and Correlation Effects on Polymer Coacervation," Macromolecules, (2017), 50(7), 3030–3037. [PDF]
  50. S. Sui, S.L. Perry, "Microfluidics: From Crystallization to Serial Time-Resolved Crystallography," Structural Dynamics, (2017) 4(3), 032202. [PDF]
  51. S. Galarza, S.L. Perry, S. R. Peyton, "A Student-Created, Open Access, Living Textbook," Chemical Engineering Education, (2017) 51(1), 2-9. [PDF]
  52. Y. Liu, H.H. Winter, S.L. Perry, "Linear Viscoelasticity of Complex Coacervates," Advances in Colloid and Interface Science, (2017) 239, 46-60. [PDF]
  53. As of July/August 2017, this highly cited paper received enough citations to place it in the top 1% of the academic field of Chemistry based on a highly cited threshold for the field and publication year (data from Essential Science Indicators).

  54. S. Sui, Y. Wang, K.W. Kolewe, V. Srajer, R. Henning, J.D. Schiffman, C. Dimitrakopoulos, S.L. Perry, "Graphene-Based Microfluidics for Serial Crystallography," Lab on a Chip, (2016) 16, 3082-3096. [PDF]
  55. Highlighted in the Lab on a Chip themed collection on Emerging Investigators.
    Highlighted in "Serial Crystallography Enhanced by Graphene," Chemistry World.
    Featured as a Science Highlight in the 2016 Annual Report for the Advanced Photon Source.
    Featured in an IALS/M2M research highlight.

  56. D. Priftis, L. Leon, Z. Song, S.L. Perry, K.O. Margossian, A. Tropnikova, J. Cheng, M. Tirrell, "Self-Assembly of α-Helical Polypeptides Driven by Complex Coacervation," Angewandte Chemie International Edition, (2015) 54, 11128-11132. [PDF]
  57. S.L. Perry, C.E. Sing, "PRISM-Based Theory of Complex Coacervation: Excluded Volume versus Chain Correlation," Macromolecules, 48, 5040-5053 (2015). [PDF]
  58. A.S. Pawate, V. Šrajer, J. Schieferstein, S. Guha, R. Henning, I. Kosheleva, M. Schmidt, Z. Ren, P.J.A. Kenis, S.L. Perry, "Towards Time-Resolved Serial Crystallography in a Microfluidic Device," Acta Crystallographica, Section F: Structural Biology and Crystallization Communications, (2015) 71, 823-830. [PDF]
  59. K.Q. Hoffmann, S.L. Perry, L. Leon, D. Priftis, M. Tirrell, J.J. de Pablo, "A Molecular View of the Role of Chirality in Charge-driven Polypeptide Complexation," Soft Matter, (2015) 11, 1525-1538. [PDF]
  60. S.L. Perry, L. Leon, K.Q. Hoffmann, M.J. Kade, D. Priftis, K.A. Black, D. Wong, R.A. Klein, C.F. Pierce, K.O. Margossian, J.K. Whitmer, J. Qin, J.J. de Pablo, and M. Tirrell, "Chirality Selected Phase Behavior in Ionic Polypeptide Complexes," Nature Communications, (2015) 6, 6052. [PDF]
  61. S.L. Perry, S. Guha, A.S. Pawate, R. Henning, I. Kosheleva, V. Šrajer, P.J.A. Kenis, Z. Ren, "In Situ Serial Laue Diffraction on a Microfluidic Crystallization Device," Journal of Applied Crystallography, (2014) 47, 1975-1982. [PDF]
  62. D.V. Krogstad, S.H. Choi, N.A. Lynd, D.J. Andrus, S.L. Perry, J.D. Gopez, C.J. Hawker, E.J. Kramer, M. Tirrell, "Small Angle Neutron Scattering Study of Complex Coacervate Micelles and Hydrogels Formed from Ionic Diblock and Triblock Copolymers," Journal of Physical Chemistry B, (2014) 118, 13011-13018. [PDF]
  63. K.A. Black, D. Priftis, S.L. Perry, J. Yip, W.Y. Byun, M. Tirrell, "Protein Encapsulation via Polypeptide Complex Coacervation," ACS Macro Letters, (2014) 3, 1088-1091. [PDF]
  64. Highlighted on the C&EN Biological and Materials News SCENE.

    Highlighted in: "Charged Polymers Package Proteins," Chemical & Engineering News, (2014) 92(45), 27.

  65. S.L. Perry, Y. Li, D. Priftis, L. Leon, M. Tirrell, "The Effect of Salt on the Complex Coacervation of Vinyl Polyelectrolytes," Polymers, (2014) 6, 1756-1772. [PDF]
  66. J. Qin, D. Priftis, R. Farina, S.L. Perry, L. Leon, J. Whitmer, K. Hoffmann, M. Tirrell, J.J. de Pablo, "Interfacial Tension of Polyelectrolyte Complex Coacervate Phases,"ACS Macro Letters, (2014) 3, 565-568. [PDF]
  67. D. Priftis, X. Xia, K.O. Margossian, S.L. Perry, L. Leon, J. Qin, J.J. de Pablo, M. Tirrell, "Ternary, Tunable Polyelectrolyte Complex Fluids Driven by Complex Coacervation," Macromolecules, (2014) 47(9), 3076-3085. [PDF]
  68. D.S. Khvostichenko, J.J.D. Ng, S.L. Perry, M. Menon, P.J.A. Kenis, "Effects of the Detergent β-Octylglucoside and Phosphate Salt Solutions on the Phase Behavior of Monoolein Mesophases," Biophysical Journal, (2013) 105(8), 1848-1859. [PDF]
  69. Featured on the journal cover. Cover art by S.L. Perry, highlighted on the Biophysical Society Blog.

  70. S.L. Perry, S.G. Neumann, T. Neumann, J. Weinstein, K. Cheng, J. Ni, D.V. Schaffer, M.V. Tirrell, "Challenges in Nucleic Acid-Lipid Films for Transfection," AIChE Journal, (2013) 59(9), 3203-3213. [PDF]
  71. D.S. Khvostichenko, E. Kondrashkina, S.L. Perry, K. Brister, P.J.A. Kenis, "An X-ray Transparent Microfluidic Platform for Screening the Phase Behavior of Lipidic Mesophases," The Analyst, (2013) 138, 5384-5395. [PDF]
  72. S.L. Perry, S. Guha, A.S. Pawate, A. Bhaskarla, V. Agarwal, S. Nair, P.J.A. Kenis, "A Microfluidic Approach for Protein Structure Determination at Room Temperature via On-Chip Anomalous Scattering," Lab on a Chip, (2013) 13 (16), 3183-3187. [PDF]
  73. Featured as the inside cover article.

    Highlighted in the Lab on a Chip Top 10% web collection.

    Highlighted as a Lab on a Chip HOT article.

  74. E. Kondrashkina, D.S. Khvostichenko, S.L. Perry, J. Von Osinski, P.J.A. Kenis, K. Brister, "Using Macromolecular-Crystallography Beamline and Microfluidic Platform for Small-Angle Diffraction Studies of Lipidic Matrices for Membrane-Protein Crystallization," Journal of Physics, Conference Series, (2013) 425(1), 012013. [PDF]
  75. S. Guha, S.L. Perry, A.S. Pawate, P.J.A. Kenis, "Fabrication of X-ray Compatible Microfluidic Platforms for Protein Crystallization," Sensors and Actuators B, (2012) 174, 1-9. [PDF]
  76. S.L. Perry, J.J.L. Higdon, P.J.A. Kenis, "Design Rules for Pumping and Metering of Highly Viscous Fluids," Lab on a Chip, (2010) 10(22), 3112-3124. [PDF]
  77. Highlighted amongst the top ten most accessed online articles for Lab on a Chip for October 2010.

  78. S. Talreja, S.L. Perry, S. Guha, V. Bhamidi, P.J.A. Kenis, C.F. Zukoski, "Determination of the Phase Diagram for Soluble and Membrane Proteins," Journal of Physical Chemistry B, (2010) 114(13), 4432-4441. [PDF]
  79. S.L. Perry, J.D. Tice, G.W. Roberts, P.J.A. Kenis, "Microfluidic Generation of Lipidic Mesophases for Membrane Protein Crystallization," Crystal Growth & Design, (2009) 9(6), 2566-2569. [PDF]
  80. Highlighted in: "Finding Crystallization Sweet Spots," Chemical & Engineering News, (2009) 87(22), 27. [PDF]

Patents (top)

  1. C. Martin, E. Cavac, K.H. Malagodapathiranage, S. Sui, S.L. Perry, Y. Gholamalipour, Novel Enzymatic Methods to Generate High Yields of Sequence Specific RNA Oligonucleotides with Extreme Precision, US Patent No. 11,578,348 B2, Feb. 14, 2023. [PDF]
  2. S.L. Perry, S. Sui, Graphene-Based Electro-Microfluidic Devices and Methods for Protein Structural Analysis, US Patent No. 11,175,244 B2, Nov. 16, 2021. [PDF]
  3. S. Sui, Y. Wang, C. Dimitrakopoulos, S.L. Perry, Microfluidic Devices and Methods of Manufacture and Use Thereof, US Patent No. 10,792,657 B2, Oct. 6, 2020. [PDF]
  4. X. Meng, S.L. Perry, J.D. Schiffman, Ultra-stable Printing and Coatings using Aqueous Complex Coacervates, and Compositions and Methods Thereof, US Patent No. 10,767,060 B2, Sept. 8, 2020. [PDF]
  5. X. Meng, S.L. Perry, J.D. Schiffman, Polymer Nanofibers from Electrospinning of Complex Coacervates, and Compositions and Methods Thereof, US Patent Number 10,428,444 B2, October 1, 2019. [PDF]
  6. P.J.A. Kenis, J.D. Tice, S.L. Perry, G.W. Roberts, Microfluidic Device for Preparing Mixtures, US Patent Number 7,976,789 B2, July 12, 2011. [PDF]

Additional Contributions (top)

  1. S. Guha, S.L. Perry, A.S. Pawate, S.K. Nair, P.J.A. Kenis, "X-ray Compatible Microfluidic Platforms for Screening, Crystallization and De Novo Structure Determination of Proteins," Proceedings µTAS, (2011) 876-878. [PDF]
  2. D.S. Khvostichenko, S.L. Perry, E. Kondrashkina, S. Guha, K. Brister, P.J.A. Kenis, "Microfluidic Platforms for On-Chip Formulation and Small-Angle X-ray Analysis of the Phase Behavior of Lipid/Water Mixtures," Proceedings µTAS, (2011) 1403-1405. [PDF]
  3. P.J.A. Kenis, J.D. Tice, S.L. Perry, G.W. Roberts, S. Talreja, "Microfluidic Chips for Membrane Protein Crystallization," Proceedings µTAS, (2007) 1, 590-592.