Nancy Donovan MD, Chief of the Division of Geriatric Psychiatry at Brigham and Women’s Hospital, Associate Researcher of Massachusetts General Hospital, and Assistant Professor of Psychiatry at Harvard Medical School, will be presenting on recent findings of Emotional and Social Function in Preclinical Alzheimer's Disease
Synopsis: Alzheimer’s disease (AD) begins with a long preclinical stage defined by the abnormal accumulation of amyloid-beta and tau proteins. These pathological proteins (biomarkers) can be measured in older adults using neuroimaging (amyloid-PET and tau PET). Transitional cognitive and neurobehavioral changes may occur during the AD pathophysiologic process prior to cognitive impairment. Our work has explored the relationship of traditional neurobehavioral symptoms such as depression and anxiety and novel neurobehavioral symptoms such as loneliness and social engagement to biomarkers of AD in older adults without cognitive impairment. Identifying these transitional changes in older adults with biological markers of AD may define those at greatest risk of progression to impairment.
All are welcome!