AMHERST, Mass. - The University of Massachusetts has been issued a patent by the United States Patent and Trademark Office for the biotechnology techniques that produced cloned, transgenic cattle in January 1998. The patent covers an improved method of cloning non-human mammals using nuclear transfer technology. The technology, which was developed on the Amherst campus in 1995, is exclusively licensed to Advanced Cell Technology (ACT), a Worcester company with University ties. Applications of the technique lie in human therapeutics, including generation of cloned cells for transplantation, and efficient production of medications that could be produced in transgenic animals.