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This chapter provides an overview of the Nanoscale Application Specific IC (NASIC) fabric. The NASIC fabric has spun several research directions by multiple groups. This overview is a snapshot of the thinking, techniques and some of the results as of to date. NASICs is targeted as a CMOS-replacement technology. The project encompasses aspects from the physical layer and manufacturing techniques, to devices, circuits and architectures, and is funded by NSF, and FENA/FCRP and CHM/NSEC nanotechnology centers.