My laboratory studies high-temperature anaerobic microorganisms that grow primarily in deep-sea hydrothermal vents. Specifically, I am interested in microbial life in the subsurface biosphere, the search for life on Earth and elsewhere, numerical modeling of microbial metabolism, microbe-mineral interactions, biomarkers, and the application of thermophiles in bioremediation and bioenergy. We employ modern biological tools to link genotypes, phenotypes, and functional responses to integrate cellular behavior within and among organisms. We employ experimental and mathematical methods to