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Stochastic effects in molecular motor teams

Stochastic effects in molecular motor teams

Molecular motors are proteins in biological cells which perform various sorts of biophysical work. The microscale physics of their operation motivates inherently stochastic models, both for their binding kinetics as well as for their spatial motion. The molecular motor kinesin, on which we will focus, carries a cargo load on its tail while its head walks along microtubule filaments. We revisit two paradigms of cooperative action by kinesin molecular motors through analysis of coupled stochastic models for the biophysical dynamics. First, we extend consideration of gliding assays to a situation where microtubules are crosslinked while being crowdsurfed by immobilized kinesin. Second, for two dissimilar types of kinesin transporting a common cargo, we provide approximate analytical characterizations for how the motors cooperate in carrying the cargo, with attention to incorporating slack in the tether connecting the motor with the cargo. The methodology combine multiscale asymptotic analysis, renewal theory, and first passage time calculations.

## Department of Mathematics and Statistics