The University of Massachusetts Amherst

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Vincent Rotello

Goessmann Professor of Chemistry, University Distinguished Professor

Our research encompasses multiple applications of nanomaterials in therapeutics and diagnostics, including both nanoparticles and nano/micropatterned surfaces.

Current Research

Cancer: We have developed highly effective strategies for protein and nucleic acid delivery that we are using to understand fundamental aspects of cancer biology. We are simultaneously translating these systems into pre-clinical models, with the goal of creating new therapeutic strategies that integrate nanotechnology, immunology and cell biology. In addition to our therapeutic design efforts we are creating new cell-based high content screening strategies that provide key mechanistic details of therapeutic mechanisms in an extremely high throughput one-well, one mechanism format.

Infection and Immunity: Our research has projects in both immunology and pathogen detection/antimicrobials. In the area of immunology, we are creating nanoparticle systems designed to regulate the immune system. These particles use engineered surface functionality to provide both pro-inflammatory behavior for next-generation adjuvants and anti-inflammatory properties for diseases such as rheumatoid arthritis.

In the area of pathogens, we have developed new diagnostics and therapeutics. In the area of diagnostics, we have very rapid systems for identifying species and strains in both planktonic (dispersed) bacteria and in biofilms. We have also developed new nanoparticle-based therapeutics targeted at both free bacteria and biofilms.

Protein Homeostasis: We have created a new nanoparticle-based delivery system that injects proteins directly into the cytosol of cells, with minimal toxicity. This delivery tool provides a therapeutic strategy for altering or maintaining protein homeostasis. Additionally, the rapidity of the delivery process (seconds/minutes) makes these vehicles fundamental tools for cell biogy, allowing real-time monitoring of intracellular protein trafficking and cellular processes.

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Academic Background

  • BSc (Honors) Illinois Institute of Technology, 1985
  • MPhil Yale University, 1987
  • PhD Yale University, 1990
  • Postdoctoral Training: NSF Postdoctoral Fellowship MIT, 1990
Rana, S.; Le, N. D. B.; Mout, R.; Saha, K.; Tonga, G. Y.; Bain, R. E. S.; Miranda, O. R.; Rotello, C. M.; Rotello, V. M. "A multichannel nanosensor for instantaneous readout of cancer drug mechanisms" Nat. Nanotechnol. 2015, 10, 65-69.
Li, X. N.; Robinson, S. M.; Gupta, A.; Saha, K.; Jiang, Z. W.; Moyano, D. F.; Sahar, A.; Riley, M. A.; Rotello, V. M. "Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria" ACS Nano 2014, 8, 10682-10686.
Moyano, D. F.; Goldsmith, M.; Solfiell, D. J.; Landesman-Milo, D.; Miranda, O. R.; Peer, D.; Rotello, V. M. "Nanoparticle Hydrophobicity Dictates Immune Response" J. Am. Chem. Soc., 2012, 134, 3965-3967.
Tang, R.; Kim, C. S.; Solfiell, D. J.; Rana, S.; Mout, R.; Velazquez-Delgado, E. M.; Chompoosor, A.; Jeong, Y.; Yan, B.; Zhu, Z. J.; Kim, C.; Hardy, J. A.; Rotello, V. M. "Direct Delivery of Functional Proteins and Enzymes to the Cytosol Using Nanoparticle-Stabilized Nanocapsules" ACS Nano 2013, 7, 6667-6673.
Fu, A.; Tang, R.; Hardie, J.; Farkas, M. E.; Rotello, V. M. "Promises and Pitfalls of Intracellular Delivery of Proteins" Bioconjugate Chem. 2014, 25, 1602-1608.
Landis, R. F.; Li, C. H.; Gupta, A.; Lee, Y. W.; Yazdani, M.; Ngernyuang, N.; Altinbasak, I.; Mansoor, S.; Khichi, M. A. S.; Sanyal, A.; Rotello, V. M., Biodegradable Nanocomposite Antimicrobials for the Eradication of Multidrug-Resistant Bacterial Biofilms without Accumulated Resistance. J. Am. Chem. Soc. 2018, 140, 6176-6182.
Ray, M.; Lee, Y. W.; Hardie, J.; Mout, R.; Tonga, G. Y.; Farkas, M. E.; Rotello, V. M. "CRISPRed Macrophages for Cell-Based Cancer Immunotherapy" Bioconjugate Chem. 2018, 29, 445-450.
Gupta, A.; Das, R.; Tonga, G. Y.; Mizuhara, T.; Rotello, V. M. "Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections" ACS Nano 2018, 12, 89-94.
Le, N. D. B.; Tonga, G. Y.; Mout, R.; Kim, S. T.; Wille, M. E.; Rana, S.; Dunphy, K. K.; Jerry, D. J.; Yazdani, M.; Ramanathan, R.; Rotello, C. M.; Rotello, V. M. "Cancer Cell Discrimination Using Host-Guest "Doubled" Arrays" J. Am. Chem. Soc. 2017, 139, 8008-8012.
Mout, R.; Ray, M.; Tay, T.; Sasaki, K.; Tonga, G. Y.; Rotello, V. M. "General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Co-engineering" ACS Nano 2017, 11, 6416-6421.
Tang, R.; Wang, M.; Ray, M.; Jiang, Y.; Jiang, Z. W.; Xu, Q. B.; Rotello, V. M. "Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags" J. Am. Chem. Soc. 2017, 139, 8547-8551.
Mout, R.; Ray, M.; Tonga, G. Y.; Lee, Y. W.; Tay, T.; Sasaki, K.; Rotello, V. M. "Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing" ACS Nano 2017, 11, 2452-2458.
Moyano, D. F.; Liu, Y. C.; Ayaz, F.; Hou, S.; Puangploy, P.; Duncan, B.; Osborne, B. A.; Rotello, V. M. "Immunomodulatory Effects of Coated Gold Nanoparticles in LPS-Stimulated In Vitro and In Vivo Murine Model Systems" Chem 2016, 1, 9.
Jiang, Y.; Wang, M.; Hardie, J.; Tonga, G. Y.; Ray, M.; Xu, Q. B.; Rotello, V. M. "Chemically Engineered Nanoparticle-Protein Interface for Real-Time Cellular Oxidative Stress Monitoring" Small 2016, 12, 3775-3779.
Saha, K.; Rahimi, M.; Yazdani, M.; Kim, S. T.; Moyano, D. F.; Hou, S.; Das, R.; Mout, R.; Rezaee, F.; Mahmoudi, M.; Rotello, V. M. "Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona" ACS Nano 2016, 10, 4421-4430.
Contact Info

Department of Chemistry
379 LGRT Tower C
710 North Pleasant Street
Amherst, MA 01003

(413) 545-2058