The University of Massachusetts Amherst
 
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Steven Sandler

Professor

Our experimental approach is to make mutations in genes that code for DNA replication and or recombination to test models about how these interactions might occur. Our assays include standard molecular techniques and fluorescence microscopy of living cells.

Current Research
Research in the Sandler lab revolves around understanding the molecular mechanisms involved in replication fork collapse, the repair of these collapsed forks and restarting the forks after repair. This involves understanding the interactions between the DNA replication and recombination protein complexes at the molecular level. These mechanisms are important to understand because they underlie the causes and treatments of cancer and the ability of bacteria to develop resistance to antibiotics. Thus, this work has been funded by the American Cancer Society in the past and is currently funded by the National Institute for Allergies and Infectious Diseases.

Learn more at www.micro.umass.edu/faculty-and-research/steven-sandler

Academic Background

  • PhD Molecular Biology, University of California, Berkeley
  • Postdoctoral Training University of California Berkeley
  • Postdoctoral Training Advanced Genetic Sciences, Oakland, CA
Shawn C. Massoni, Michael C. Leeson, Jarukit Edward Long, Kristin Gemme, Alice Mui and Steven J. Sandler (2012) Factors limiting SOS expression in log phase cells in Escherichia coli. Journal of Bacteriology 194(19):5325. PMID# 22843848..
Marielle C. Gruenig, Nicholas Renzette, Edward Long, Sindhu Chitteni-Pattu, Ross B. Inman, Michael M. Cox and Steven J. Sandler (2008) RecA-mediated SOS induction requires an extended filament conformation but no ATP hydrolysis. Molecular Microbiology 69(5): 1165-1179. PMID # 18627467.
Nicholas Renzette, Nathan Gumlaw, Jared T. Nordman, Marlee Krieger, Su-Ping Yeh, Edward Long, Richard Centore, Ruethairat Boonsombat and Steven J. Sandler (2005) Localization of RecA in E. coli K-12 Using RecA-GFP. Molecular Microbiology 57(4): 1074-1085. PMID # 16091045.
Sandler, Steven J. (2000) Multiple Genetic Pathways for Restarting DNA Replication Forks in E. coli K-12. Genetics 155 (2): 487-497. PMID # 10835375.
 
Contact Info

Department of Microbiology
304 Morrill Science Center IV North
Amherst, Ma 01003

(413) 577-4391
sandler@microbio.umass.edu

www.micro.umass.edu/faculty-and-research/steven-sandler