Our experimental approach is to make mutations in genes that code for DNA replication and or recombination to test models about how these interactions might occur. Our assays include standard molecular techniques and fluorescence microscopy of living cells.
Research in the Sandler lab revolves around understanding the molecular mechanisms involved in replication fork collapse, the repair of these collapsed forks and restarting the forks after repair. This involves understanding the interactions between the DNA replication and recombination protein complexes at the molecular level. These mechanisms are important to understand because they underlie the causes and treatments of cancer and the ability of bacteria to develop resistance to antibiotics. Thus, this work has been funded by the American Cancer Society in the past and is currently funded by the National Institute for Allergies and Infectious Diseases.
Learn more at www.micro.umass.edu/faculty-and-research/steven-sandler
- PhD Molecular Biology, University of California, Berkeley
- Postdoctoral Training University of California Berkeley
- Postdoctoral Training Advanced Genetic Sciences, Oakland, CA