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Shelly R. Peyton

Associate Professor

Research areas include biomaterial platforms, human cell-material interactions, cardiovascular disease, test beds to study personalized chemotherapeutics, and regenerative medicine.

Current Research
Our lab creates biomaterial systems as “tissue mimics” to study disease progression and drug response. We are particularly interested in combining these tissue mimics with cells from individual patients, to A) provide personalized risk assessments related to heart disease and cancer, and B) provide new insight toward personalized drugs and drug combinations. Our biomaterials systems mimic human tissue, and when combined with human cells, make up an environment that we can use on the bench top to rapidly and reproducibly study human disease, on a patient-by-patient basis.

Learn more at www.peytonlab.org/

Academic Background

  • BS Northwestern University, 2002
  • MS University of California Irvine, 2004
  • PhD University of California Irvine, 2007
  • Postdoctoral Training: Massachusetts Institute of Technology
Schwartz., A.D., Barney, L.E., Jansen, L.E., Nguyen, T.V., Hall, C.L., Meyer, A.S., and Peyton, S.R.* (2018), A Biomaterial Screening Approach to Reveal Microenvironmental Mechanisms of Drug Resistance Integr. Biol., 2017, DOI: 10.1039/C7IB00128B
Tran, Y.H., Rasmuson, M.J., Emrick, T.S., Klier, J.*, and Peyton, S.R.* (2018), Strain-stiffening gels based on latent crosslinking Soft Matter, 2017,13, 9007-9014
S.M. Page, S. Parelkar, A. Gerasimenko, D.Y. Shin, S.R. Peyton, and T.S. Emrick (2014) "Promoting cell adhesion on slippery phosphorylcholine hydrogel surfaces". Journal of Materials Chemistry B. DOI: 10.1039/C3TB21493A.
T.V. Nguyen, M. Sleiman, T. Moriarty, W.G. Herrick, S.R. Peyton (2014) "Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening". Biomaterials. DOI: 10.1016/j.biomaterials.2014.03.058.
S.R. Peyton and A.J. Putnam. (2005) “Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion.” Journal of Cellular Physiology. 204(1):198-209.
 
Contact Info

Department of Chemical Engineering
N531 Life Sciences Laboratories
240 Thatcher Way
Amherst MA 01003-9364

(413) 545-1133
speyton@ecs.umass.edu

www.peytonlab.org/