Research areas include deciphering the role of impaired mitochondrial metabolism in cancer, diabetes and neurodegeneration by developing cellular and animal models; and developing methods and technologies to assess different aspects of mitochondrial metabolism under physiological conditions.
Mitochondrion is the site of oxidative metabolism that involves two major processes, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OxPhos). They are dynamically linked with glycolysis, fatty acids β-oxidation, ATP generation and regulation of redox status. Impairments of oxidative metabolism are linked with both common and rare diseases. Genetic deficiencies of OxPhos are the underlying cause of fatal mitochondrial encephalomyopathies in children. A novel mouse model for systemic partial OxPhos deficiency is developed to determine predispositions to cancer, diabetes and neurodegeneration and find causal relationships with tissue- and -disease specific profiles of metabolites, gene expressions, deregulated immune response and inflammation. My group has recently developed a technology that permits analysis of mitochondrial metabolism in situ. Using this technology we aim to develop assays for monitoring the variation in human mitochondrial metabolism under normal and pathophysiological conditions.
- BS Banaras Hindu University, Varanasi, India, 1989
- MS University of Baroda, Vadodara, India, 1991
- PhD Jawaharlal Nehru University, New Delhi, India, 1998
- Postdoctoral Training: Buck Institute for Age Research, 2005-2008; Division of Biological Sciences, University of California San Diego, 1998-2005; Chicago Medical School, 1997-1998