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Nagendra Yadava

Adjunct Assistant Professor, Department of Biology; Principal Investigator, Pioneer Valley Life Sciences Institute; Assistant Professor, Tufts University School of Medicine, Baystate Medical Center

Research areas include deciphering the role of impaired mitochondrial metabolism in cancer, diabetes and neurodegeneration by developing cellular and animal models; and developing methods and technologies to assess different aspects of mitochondrial metabolism under physiological conditions.

Current Research
Mitochondrion is the site of oxidative metabolism that involves two major processes, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OxPhos). They are dynamically linked with glycolysis, fatty acids β-oxidation, ATP generation and regulation of redox status. Impairments of oxidative metabolism are linked with both common and rare diseases. Genetic deficiencies of OxPhos are the underlying cause of fatal mitochondrial encephalomyopathies in children. A novel mouse model for systemic partial OxPhos deficiency is developed to determine predispositions to cancer, diabetes and neurodegeneration and find causal relationships with tissue- and -disease specific profiles of metabolites, gene expressions, deregulated immune response and inflammation. My group has recently developed a technology that permits analysis of mitochondrial metabolism in situ. Using this technology we aim to develop assays for monitoring the variation in human mitochondrial metabolism under normal and pathophysiological conditions.

Academic Background

  • BS Banaras Hindu University, Varanasi, India, 1989
  • MS University of Baroda, Vadodara, India, 1991
  • PhD Jawaharlal Nehru University, New Delhi, India, 1998
  • Postdoctoral Training: Buck Institute for Age Research, 2005-2008; Division of Biological Sciences, University of California San Diego, 1998-2005; Chicago Medical School, 1997-1998
Kim C., Patel P., Gouvin, L.M., Brown, M.L., Khalil, A., Henchey, E.M., Heuck A.P., Yadava N., (2014): Comparative analysis of the mitochondrial physiology of pancreatic cells. Bioenergetics, 3: 110.
Divakaruni A.S., Wiley S.E., Rogers G.W., Andreyev A.Y., Petrosyan S., Loviscach M., Wall, E.A., Yadava N., Heuck A.P., Ferrick, D.A., Henry R.R., McDonald W.G., Colca J.R., Simon M.I., Ciaraldi T.P., Murphy A.N. (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc. Natl. Acad. Sci., 110(14):5422-7
Yadava N., Schneider S., Jerry D.J., Kim C., (2013) Impaired mitochondrial metabolism and mammary carcinogenesis. J. Mammary Gland Biol. 18:75-87
Compton C., Kim C., Griner N.B., Potluri P., Scheffler I.E., Sen S., Jerry D.J., Schneider S., Yadava N. (2011): Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J. Biol. Chem., 286(23): 20297-20312
Gerencser A.A., Neilson A., Choi S.W., Edman U., Yadava N., Oh R.J., Ferrick D.A., Nicholls DG., Brand MD. (2009) Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion. Anal Chem., 81: 6868-6878
 
Contact Info

Pioneer Valley Life Sciences Institute
3601 Main St. Rm 2114
Springfield MA 01107

(413) 794-0786
Nagendra.Yadava@baystatehealth.org