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Mingxu You

Assistant Professor

Our research group is interested in creating synthetic DNA- and RNA-based tools for analytical and biomedical applications. Our research program integrates the disciplines of chemistry, bionanotechnology, cellular biology, and synthetic biology. Our ultimate goal is to understand the fundamentals of life, and to construct artificial genetic devices and pathways.

Current Research
Currently we have four primary research focuses:

1. Engineer fluorogenic RNA-based sensors for intracellular imaging of RNAs, metabolites, and signaling molecules.

2. Systematically evolve functional aptamers and ribozymes based on high-throughput approaches.

3. Develop DNA-based devices for measuring forces and imaging mechanotransduction events at cell-cell junction.

4. Engineer novel DNA probes that can measure transient membrane lipid encounter events and other biophysical events at cell membranes.

 

Learn more at elements.chem.umass.edu/youlab/

Academic Background

  • BS Chemistry, Peking University, 2008
  • PhD Chemistry, University of Florida, 2012
  • Postdoctoral Scholar, Nano-Optic Joint Program between UF and MSU, 2013
  • Postdoctoral Scholar, Pharmacology, Weill Medical College, Cornell University, 2014-2016
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
M. You#*, Y. Lyu#, D. Han#, L. Qiu, Q. Liu, T. Chen, C. Wu, L. Peng, L. Zhang, G. Bao & W. Tan*. (2017) A DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes. Nature Nanotechnology, 12, 453-459. (# Co-first author)
D. Han#, C. Wu#, M. You#, T. Zhang, T. Chen, L. Qiu, Z. Zheng & W. Tan. (2015) A cascade reaction network mimicking the basic functional steps of acquired immune response. Nature Chemistry, 7, 835-841. (# Co-first author)
M. You#, J.L. Litke# & S.R. Jaffrey. (2015) Imaging metabolite dynamics in living cells using a spinach-based riboswitch. Proc Natl Acad Sci USA, 112, E2756-E2765.
 
Contact Info

Department of Chemistry
867 LGRT
710 North Pleasant Street
Amherst, MA 01003-9292

(413) 545-4711
mingxuyou@chem.umass.edu

www.chem.umass.edu/faculty/you.html