Michael A. Henson
Research areas focus on system-scale spatiotemporal models with applications to microbial communities and neural networks involved in human health and disease processes. Our current activities associated with the Models to Medicine theme include multispecies bacterial biofilms responsible for chronic wound infections and circadian neural networks responsible for daily timekeeping in humans. In each case, collaborators investigate system behavior through in vitro experimental models and we develop multicellular models to rationalize, quantify, predict and manipulate system behavior. We expect our integrated experimental-computational approach to generate new antibiotic treatment regimens for chronic wound infections and novel chronotherapies for circadian and sleep related disorders.
Projects related to Models to Medicine theme include:
- Genome-scale modeling of multispecies biofilms with temporal and spatial resolution to unravel biofilm design principles and to develop model-based antibiotic treatment protocols for chronic wound infections.
- Multicellular modeling of the mammalian circadian clock with cellular and network heterogeneities to better understand intracellular design strategies and to develop model-based chronotherapies for circadian and sleep related disorders.
Learn more at www.ecs.umass.edu/che/henson_group/
- BS Chemical Engineering, University of Colorado, Boulder, 1985
- MS Chemical Engineering, University of Texas, Austin, 1988
- PhD Chemical Engineering, University of California, Santa Barbara, 1992