Programmed cell death is a fundamental component of development and homeostasis in virtually all organisms. Defects in the regulation of cell death serves as the basis of many human diseases, including autoimmunity, neurodegeneration and most cancers.
Our lab focuses the molecular mechanisms that mediate programmed cell death during development and pathogenesis. We exploit an invertebrate model (metamorphosis in holometabolous insects) to identify novel genes and molecular pathways that mediate cell death and then extend these insights into vertebrate models, including human disease.
- AB. Northwestern University, 1976
- PhD University of Washington, Seattle, 1982
- Postdoctoral training: 1982-1984 University of Washington, Seattle; 1984-1987 University of North Carolina, Chapel Hill; 1995-1996 Whitehead Institute for Biomedical Sciences