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Lauren Andrews

Assistant Professor, Marvin and Eva Schlanger Faculty Fellow in Chemical Engineering
  • Synthetic biology and genome engineering
  • Metabolic engineering of model and non-model bacteria
  • Synthetic gene networks and genetically-encoded biosensors
  • High-throughput tools for genetic design optimization

The Andrews Lab aims to uncover genetic design rules to reprogram regulation and metabolism in living cells for applications in health and biotechnology. To precisely control how a cell senses, remembers, and responds to its environment, we engineer synthetic gene networks and study their dynamics with experimental and modeling approaches. We develop high-throughput methodologies to build and interrogate large libraries of design variants using multiplexed DNA assembly, next-generation sequencing, and model-guided approaches to specify genetic diversity. This allows us to generate rich datasets that systematically and quantitatively investigate relationships between genetic composition of a design and its function in the context of the cell. With these tools and systems, our lab is working to advance the tremendous potential of harnessing living cells to autonomously sense and respond to their environment and utilize the remarkable biosynthetic machinery of biological systems to manufacture complex molecules.

Learn more at https://che.umass.edu/faculty/lauren-andrews

Academic Background

  • Postdoc, Massachusetts Institute of Technology, Biological Engineering and Broad Institute of MIT and Harvard, MIT-Broad Foundry
  • Ph.D., University of Colorado Boulder, Chemical Engineering, 2012
  • M.S., University of Colorado Boulder, Chemical Engineering, 2009
  • B.S., Cornell University, Chemical Engineering, 2006
Andrews LB, Nielsen AAK and Voigt CA. Cellular checkpoint control using programmable sequential logic. Science (in press).
 
Contact Info

Department of Chemical Engineering
University of Massachusetts Amherst
N265 Life Sciences Laboratories
240 Thatcher Rd
Amherst MA 01003-9364

Office: (413) 545-1660
Email:  lbandrews@umass.edu