The University of Massachusetts Amherst
 
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Laura N. Vandenberg

Assistant Professor

Research areas include biomarkers of exposure, pre-cancerous indicators, in vivo models, and environmental factors.

Current Research
My research group explores how early life exposures to chemicals and chemical mixtures can predispose individuals to diseases that manifest later in life. Our work aims at:

  1. developing new in vivo tools to assess cancer risk factors following environmental insults,
  2. developing robust, state-of-the-art methods that can be used by chemists to assess the toxicity of compounds, including their endocrine disrupting potential, and identify ‘safer’ alternatives, and
  3. understanding why traditional approaches to risk assessments have failed to identify the toxic properties of many ubiquitous environmental chemicals.

Although classical toxicology examines how fetal chemical exposures can produce birth defects, our work instead addresses how low doses of chemicals during critical windows of development can alter gene expression, cell differentiation, and tissue organization in subtle ways that can lead to adult diseases including cancer, obesity, and infertility. Our work has shown that compounds that mimic or block the actions of natural hormones, so-called endocrine disruptors, can disrupt the development of organs in subtle ways, but that these subtle changes represent risk factors for deadly adult diseases. The mammary gland is a highly sensitive organ to compounds that disrupt estrogen, progesterone, androgen and growth hormone signaling pathways. Using this organ as a sensitive read-out allows us to identify compounds that can disrupt the sensitive hormonal milieu of the developing organism.

Working in collaboration with Green Chemists and other Environmental Health Scientists, we have been working to improve the methods that are available to screen environmental chemicals for toxicity. These methods can be used by chemists to increase the likelihood that new products are devoid of endocrine disrupting properties. We expect that these emerging, state-of-the-art assays will provide significant improvements over the traditional assays that have widely failed to identify endocrine disrupting chemicals.

Finally, work from our lab and our collaborations with governmental and academic scientists has focused on how chemical safety assessments can be improved. Historically, risk assessments have failed to appreciate how some compounds can contribute to diseases such as breast cancer, especially when exposures to humans are quite low. Our work has focused on understanding the toxicokinetic properties of environmental chemicals, their sources and different routes of exposure, and identifying the most sensitive and reliable methods for assessing toxicity.

Learn more at www.umass.edu/sphhs/person/faculty/laura-n-vandenberg

Academic Background

  • BS Biology, Cornell University, 2003
  • PhD Cell, Molecular & Developmental Biology, Tufts University School of Medicine, 2008
  • Postdoctoral Fellowship Forsyth Institute & Harvard School of Dental Medicine, 2007-2008
  • Postdoctoral Fellowship Tufts University, 2008-2013
Vandenberg LN, Wadia PR, Schaeberle CM, Rubin BS, Sonnenschein C, Soto AM. 2006. The mammary gland response to estradiol: monotonic at the cellular level, non-monotonic at the tissue-level of organization? Journal of Steroid Biochemistry and Molecular Biology 101: 263-74.
Vandenberg LN, Schaeberle CM, Rubin BS, Sonnenschein C, Soto AM. 2013. The male mammary gland: a target for the xenoestrogen bisphenol A. Reproductive Toxicology. 37: 15-23.
Vandenberg LN, Maffini MV, Schaeberle CM, Ucci AA, Sonnenschein C, Rubin BS, Soto AM. 2008. Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice. Reproductive Toxicology 26: 210-9.
Schug, TT, Abagyan R, Blumberg B, Collins TJ, Crews D, DeFur PL, Dickerson SM, Edwards TM, Gore AC, Guillette LJ, Hayes T, Heindel JJ, Moores AR, Patisaul HB, Tal TL, Thayer KA, Vandenberg LN, Warner J, Watson CS, vom Saal FS, Zoeller RT, O’Brien KP, Myers JP. 2013. Designing endocrine disruption out of the next generation of chemicals. The Green Chemistry Journal. 15(1): 181-98
Vandenberg LN, Catanese MC. 2014. Casting a wide net for endocrine disruptors. Chemistry & Biology. 21(6): 705-6.
Vandenberg LN, Colborn T, Hayes T, Heindel JJ, Jacobs D, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT, Myers JP. 2012. Hormones and endocrine disrupting chemicals: low dose effects and non-monotonic dose responses. Endocrine Reviews. 33(3): 378-455.
Vandenberg LN, Colborn T, Hayes T, Heindel JJ, Jacobs D, Lee DH, Myers JP, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT. 2013. Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology. Reproductive Toxicology. 38: 1-15
 
Contact Info

School of Public Health, Division of Environmental Health Sciences
149B Goessmann
686 North Pleasant Street
Amherst, MA 01003-9292

(413) 577-7405
lvandenberg@schoolph.umass.edu

www.umass.edu/sphhs/person/faculty/laura-n-vandenberg