Howard Smithline, MD, MS
My research interests broadly involve the diagnosis and treatment of critically ill patients (congestive heart failure, sepsis, as well as myocardial and cerebral ischemia) in the Department of Emergency Medicine. This is being done collaboratively with the Pioneer Valley Life Science Institute (PVLSI), Institute of Applied Life Sciences (IALS), the Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL), The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN), Tufts Center for the Study of Drug Development (Tufts CSDD), and Tufts Clinical and Translational Science Institute (Tufts CTSI).
My current research is studying the role of nicotinic adenine dinucleotide (NAD) on glycolysis and oxidative phosphorylation in leukocytes of patients with congestive heart failure. This work is being conducted collaboratively with Dr. Nagendra Yadava.
I am also studying the measurement of nicotinic adenine dinucleotide (NAD), its relationship to oxidative phosphorylation, as well as the pharmacodynamics of supplemental nicotinamide riboside (a NAD precursor) in skeletal muscle, heart, and brain using noninvasive magnetic resonance spectroscopy. This work is being conducted collaboratively with Dr. Rajakumar Nagarajan.
Academic Background
- B.S., Medicine (6-year Medical Program), Northwestern University, Chicago, IL 1981-1985.
- M.D., Northwestern University, Chicago, IL 1983-1987.
- M.S., Statistical Analysis & Clinical Research Design, University of Michigan, Ann Arbor, MI 1991-1993.
Postdoctoral Training:
- Internship (Transitional), Henry Ford Hospital, Detroit, MI 1987-1988.
- Residency (Emergency Medicine), Henry Ford Hospital, Detroit, MI 1988-1991.
- Fellowship (Emergency Medicine Research), Henry Ford Hospital, Detroit, MI 1991-1993.
