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Hang Xiao

Associate Professor

Research area is in cancer chemoprevention.

Current Research

Epidemiological evidence has indicated that diet abundant in fruits and vegetables may reduce the risk of chronic diseases such as cancer, and this effect has been attributed to bioactive components present in these foods. For example, it was estimated that one-third of cancer cases might be preventable by dietary modification.

My research is focused on identifying and characterizing potential disease preventive dietary components (nutraceuticals), elucidating their molecular mechanisms, investigating possible synergistic interactions among these dietary components, enhancing biological activities and bioavailability of dietary components by food processing and nanotechnology, with the long-term goal of developing diet-based strategies for the prevention of chronic diseases. A key focus of current research is on the interactions among dietary components, human body and gut microbiome in the context of health impacts. I am also working on the toxicology of food components such as certain food additives. The major approach of this research is the combination of chemistry, biochemistry, molecular biology and nanotechnology in cell cultures, animal models as well as human trials.

Learn more at www.umass.edu/foodsci/faculty/hang-xiao

Academic Background

  • BEng Ocean University of China, Qingdao, P. R. China
  • PhD University of Wisconsin-Madison
  • Postdoctoral Training: Rutgers, the State University of New Jersey
Wu, Xian, Mingyue Song, Peiju Qiu, Kanyasiri Rakariyatham, Fang Li, Zili Gao, Xiaokun Cai et al. "Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis." Carcinogenesis 38, no. 4 (2017): 455-464.
Wu, Xian, Mingyue Song, Minqi Wang, Jinkai Zheng, Zili Gao, Fei Xu, Guodong Zhang, and Hang Xiao. "Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis." Molecular nutrition & food research 59, no. 12 (2015): 2383-2394.
Sun, Yue, Xian Wu, Xiaokun Cai, Mingyue Song, Jinkai Zheng, Che Pan, Peiju Qiu et al. "Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells." Molecular nutrition & food research 60, no. 9 (2016): 1924-1932.
Wu, Xian, Mingyue Song, Zili Gao, Yue Sun, Minqi Wang, Fang Li, Jinkai Zheng, and Hang Xiao. "Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression." The Journal of nutritional biochemistry 42 (2017): 17-25.
 
Contact Info

Department of Food Science
338 Chenoweth Laboratory
100 Holdsworth Way
Amherst, MA 01003

(413) 545-2281
hangxiao@foodsci.umass.edu

www.umass.edu/foodsci/faculty/hang-xiao