Research area is in cancer chemoprevention.
My research is focused on identifying potential disease preventive dietary components (nutraceuticals), elucidating their molecular mechanisms, investigating possible synergistic interactions among these nutraceuticals and commonly used pharmacological compounds, enhancing biological activities of nutraceuticals by food processing and nanotechnology, with the long-term goal of developing diet-based strategies for the prevention of chronic diseases such as colitis and colorectal cancer. The major approach of this research is the utilization of chemical, biochemical & molecular biology in cell cultures combined with in vivo animal models for human diseases.
One type of nutraceuticals we are working on are flavonoids from citrus fruits. By systematically investigating the biological fate of these flavonoids, we have established their absorption and metabolism in the gastrointestinal tract i.e. the stomach, small intestine and large intestine. An interesting finding is that human gut microflora can transform these flavonoids into metabolites with potent biological activities (e.g. anti-carcinogenesis, and anti-inflammation) in the colon, suggesting a promising role of these flavonoids in inhibiting colonic inflammation and carcinogenesis.
Learn more at www.umass.edu/foodsci/faculty/hang-xiao
- BEng Ocean University of China, Qingdao, P. R. China
- PhD University of Wisconsin-Madison
- Postdoctoral Training: Rutgers, the State University of New Jersey