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Hang Xiao

Associate Professor

Research area is in cancer chemoprevention.

Current Research

My research is focused on identifying potential disease preventive dietary components (nutraceuticals), elucidating their molecular mechanisms, investigating possible synergistic interactions among these nutraceuticals and commonly used pharmacological compounds, enhancing biological activities of nutraceuticals by food processing and nanotechnology, with the long-term goal of developing diet-based strategies for the prevention of chronic diseases such as colitis and colorectal cancer. The major approach of this research is the utilization of chemical, biochemical & molecular biology in cell cultures combined with in vivo animal models for human diseases.

One type of nutraceuticals we are working on are flavonoids from citrus fruits. By systematically investigating the biological fate of these flavonoids, we have established their absorption and metabolism in the gastrointestinal tract i.e. the stomach, small intestine and large intestine. An interesting finding is that human gut microflora can transform these flavonoids into metabolites with potent biological activities (e.g. anti-carcinogenesis, and anti-inflammation) in the colon, suggesting a promising role of these flavonoids in inhibiting colonic inflammation and carcinogenesis.

Learn more at www.umass.edu/foodsci/faculty/hang-xiao

Academic Background

  • BEng Ocean University of China, Qingdao, P. R. China
  • PhD University of Wisconsin-Madison
  • Postdoctoral Training: Rutgers, the State University of New Jersey
Wu, Xian, Mingyue Song, Peiju Qiu, Kanyasiri Rakariyatham, Fang Li, Zili Gao, Xiaokun Cai et al. "Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis." Carcinogenesis 38, no. 4 (2017): 455-464.
Wu, Xian, Mingyue Song, Minqi Wang, Jinkai Zheng, Zili Gao, Fei Xu, Guodong Zhang, and Hang Xiao. "Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis." Molecular nutrition & food research 59, no. 12 (2015): 2383-2394.
Sun, Yue, Xian Wu, Xiaokun Cai, Mingyue Song, Jinkai Zheng, Che Pan, Peiju Qiu et al. "Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells." Molecular nutrition & food research 60, no. 9 (2016): 1924-1932.
Wu, Xian, Mingyue Song, Zili Gao, Yue Sun, Minqi Wang, Fang Li, Jinkai Zheng, and Hang Xiao. "Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression." The Journal of nutritional biochemistry 42 (2017): 17-25.
 
Contact Info

Department of Food Science
338 Chenoweth Laboratory
100 Holdsworth Way
Amherst, MA 01003

(413) 545-2281
hangxiao@foodsci.umass.edu

www.umass.edu/foodsci/faculty/hang-xiao