A B C D E F G H J K L M N O P R S T V W X Y Z

Please select the first letter of the last name you are looking for.

Anna Green

Assistant Professor

Our group aims to understand the genetic basis of antibiotic resistance in bacteria, with a particular emphasis on newly evolving mechanisms of resistance. Using machine learning applied to genomic sequences, combined with a deep understanding of molecular biology and bacterial genomics, we aim to build models that can both accurately predict antibiotic resistance from genome sequences, and also provide interpretable outputs about the genetic basis of resistance. Our long-term goal is for these models to detect newly evolved resistance, and even predict the potential of certain pathogens to evolve resistance. We are also striving to convert our understanding of resistance genomics into an ability to discover new antibiotics that will target essential cellular processes.

Current Research

Research focuses on three areas: (1) using the three-dimensional structure of proteins to contextualize mutations detected in genome sequence data, (2) analyzing huge dataset of bacterial genomes to detect new resistance genes, and (3) discovering new drugs to treat Mycobacterium
tuberculosis via machine learning.

Learn more at groups.cs.umass.edu/sage/

Academic Background

  • Postdoctoral Fellow, Biomedical Informatics, Harvard Medical School, 2019 - 2023
  • PhD, Systems Biology, Harvard University, 2019
  • BS, Molecular and Cell Biology, University of Connecticut, 2013
Green, A.G., Yoon, C.H., Chen, M.L. et al. A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis. Nat Commun 13, 3817 (2022).
Green AG et al, Analysis of Genome-Wide Mutational Dependence in Naturally Evolving Mycobacterium tuberculosis Populations, Molecular Biology and Evolution, Volume 40, Issue 6, June 2023.
 
Contact Info

Manning College of Information & Computer Sciences
348 CS Building
140 Governors Drive
Amherst, MA 01003-9292

(413) 577-0354
annagreen@umass.edu
https://www.cics.umass.edu/people/green-anna