Alexander (Sasha) Suvorov
Associate Professor
Research areas include environmental toxicology, bioinformatics, mechanisms of epigenetic inheritance and mechanisms of aging.
Current Research
We try to dissect, how environmental factors and molecular mechanisms play together to determine epigenetic aging of tissues. Specifically, we focus on changes in metabolic profile and epigenetic program transferred to the next generation with sperm. To answer these questions we use broad range of method with a particular focus on high-throughput, sequencing based methods and bioinformatics analysis.
Learn more at www.umass.edu/sphhs/person/faculty/alexander-suvorov
Academic Background
- BS Moscow State Pedagogical University, 1990
- PhD Ecology and Evolution Institute of the Russian Academy of Sciences, 1994
- DrSci Ecology and Evolution Institute of the Russian Academy of Sciences, 2006
- Postdoctoral research, Sherbrooke University, 2007-2010;
- Postdoctoral Research, Boston University, 2010-2013
Suvorov, A.; Salemme, V.; McGaunn, J.; Poluyanoff, A.; Teffera, M.; Amir, S. 2020.Unbiased Approach for the Identification of Molecular Mechanisms Sensitive to Chemical Exposures. Chemosphere, 262 (2021) 128362, 1-16, https://doi.org/10.1016/j.chemosphere.2020.128362.
Gomez M.V., Dutta M., Suvorov A., Shi X., Gu H., Eng A., Borenstein E., Mani S., Cui J.Y. 2020. Early life exposure to environmental contaminants (BDE-47, TBBPA, and BPS) produced persistent gut dysbiosis in adult male mice. Toxicological Sciences. Accepted.
Oluwayiose O.A., Wu H., Saddiki H., Whitcomb B.W., Balzer L.B., Brandon N., Suvorov A., Tayyab R., Sites C.K., Hill L., Marcho C., Pilsner R.J. Sperm DNA methylation mediates the association of male age on reproductive outcomes among couples undergoing infertility treatment. Scientific Reports. Resubmitted
Suvorov A, Naumov V, Shtratnikova V, Logacheva M, Shershebnev A, Wu H, Gerasimov E, Zheludkevich A, Pilsner JR, Sergeyev O. 2020. Rat liver epigenome programing by perinatal exposure to 2,2',4'4'-tetrabromodiphenyl ether. Epigenomics.12(3):235-249. doi: 10.2217/epi-2019-0315.
Qi W, Clark JM, Suvorov A, Park Y. 2019. Ivermectin decreases triglyceride accumulation by inhibiting adipogenesis of 3T3-L1 preadipocytes. Food Chem Toxicol. 131:110576. doi: 10.1016/j.fct.2019.110576.
Intlekofer KA, Clements K, Woods H, Adams H, Suvorov A, Petersen SL. 2019. Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells. PLoS One. 14(4):e0215389. doi: 10.1371/journal.pone.0215389.
Khalil A, Cevik SE, Hung S, Kolla S, Roy MA, Suvorov A. 2018. Developmental Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice. Front Endocrinol (Lausanne). 9:548. doi: 10.3389/fendo.2018.00548.
Pilsner JR, Shershebnev A, Medvedeva YA, Suvorov A, Wu H, Goltsov A, Loukianov E, Andreeva T, Gusev F, Manakhov A, Smigulina L, Logacheva M, Shtratnikova V, Kuznetsova I, Speranskiy-Podobed P, Burns JS, Williams PL, Korrick S, Lee MM, Rogaev E, Hauser R, Sergeyev O. 2018. Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults. Reprod Toxicol. 2018 Jun;78:40-49. doi: 10.1016/j.reprotox.2018.03.007.
Abrha A, Suvorov A. 2018. Transcriptomic Analysis of Gonadal Adipose Tissue in Male Mice Exposed Perinatally to 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47). Toxics. 6(2). doi: 10.3390/toxics6020021.
Suvorov A, Shershebnev A, Wu H, Medvedeva Y, Sergeyev O, Pilsner JR. 2018. Perinatal exposure to low dose 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) alters sperm DNA methylation in adult rats. Reprod Toxicol. 75:136-143. doi: 10.1016/j.reprotox.2017.10.009.
